Volume 7, Number 3 (volume 7, number3 2015)                   IJDO 2015, 7(3): 105-111 | Back to browse issues page


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Afkhami-Ardekani A, Motamedzadeh M R, Jam Ashkezari S, Afkhami-Ardekani M. The Effect of Magnesium and Zinc on Glycemic Control in Type 2 Diabetic Patients. IJDO. 2015; 7 (3) :105-111
URL: http://ijdo.ssu.ac.ir/article-1-249-en.html

Professor of Endocrinology, Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (693 Views)

Objective: The aim of this study was to evaluate the effect of zinc and magnesium supplementation on glycemic control and serum insulin in type 2 diabetic patients.

Materials and Methods: In this randomized clinical trial 70 diabetic patients who referred to Yazd Diabetes Center were selected. Subjects received 500 mg/day magnesium oxide or 100 mg/day zinc sulfate randomly for 8 weeks. At the start and end of treatment period fasting blood sugar (FBS), 2 hour postprandial glucose (2-hpp), glycated hemoglobin (HbA1C) and fasting insulin level were measured.

Results: Magnesium and Zinc supplementation for 8 weeks cause significantly decrease in HbA1c (P=0.005, P=0.001).No significantly difference was observed after trial between magnesium and zinc groups in FBS (42.08 ±7.43 vs. 35.15 ± 6.52) (P=0.97), HbA1C (1.22±0.21 vs. 1.77±0.32) (P=0.07) and fasting serum insulin (39.81 ±7.03 vs.36.68±6.81) (P=0.83) respectively.

Conclusion: Results of this study showed that 500 mg/day magnesium oxide or 100 mg/day zinc sulfate administration for 8 weeks could improve HbA1C in type 2 diabetic patients and this effect is same in two groups. But more studies for evaluating effect of magnesium and zinc supplementation on type 2 diabetic patients were suggested.

Full-Text [PDF 122 kb]   (451 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/08/25 | Accepted: 2016/08/25 | Published: 2016/08/25

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