Volume 8, Number 3 (volume 8, number 3 2016)                   IJDO 2016, 8(3): 142-150 | Back to browse issues page


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Roozbayani M, Peeri M, Agha-Alinejad H, Azarbayjani M A. Effect of Continues Training and High Intensity Interval Training on miR-29a and CTGF Gene Expression in Male Wistar Diabetic Rats’ Heart Tissue. IJDO. 2016; 8 (3) :142-150
URL: http://ijdo.ssu.ac.ir/article-1-310-en.html

Professor of Exercise Physiology, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (165 Views)
Objective: High-intensity interval training (HIIT) and continues aerobic training (CT) have cardio-protective effects in diabetic rats. The functional role of microRNA in heart was studied. Only miR-29a levels were found to correlate with cardiac fibrosis, This study tests the hypothesis that applying HIIT and CT cases miR-29a increasing is associated with a reduction of connective tissue growth factor (CTGF)  induced cardiac fibrosis.
Materials and Methods: In this randomized controlled trial, 18 male diabetic rats were included. They were divided into 3 groups called as HIIT, CT and control. Exercise protocol was performed 5 days/week for 5 weeks. The miR-29a and CTGF synthesis were compared between the groups by real time- PCR.
Results: Our results demonstrated that elevation of miR-29a using HIIT (2.67 , P=0.010,) or CT (1.79 , P=0.002) are effective in inhibiting CTGF (HIIT:0.17 P=0.000-CT:0.39 -induced cardiac fibrosis, suggesting that these types training would be selected as a new adjunctive therapy in the heart fibrosis- derived diabetic.
Discussion: The HIIT and CT showed increased levels of miR-29a compared CT group which is shown to decrease CTGF level resulting into lowered fibrosis of heart tissue in diabetic patients.

 
Full-Text [PDF 933 kb]   (54 Downloads)    
Type of Study: Research | Subject: Special
Received: 2017/08/2 | Accepted: 2017/08/2 | Published: 2017/08/2

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