دوره 8، شماره 4 - ( volume 8, number 4 1395 )                   جلد 8 شماره 4 صفحات 183-190 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Roozbayani M, Peeri M, Agha-Alinejad H, Azarbayjani M A. Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats. IJDO. 2016; 8 (4) :183-190
URL: http://ijdo.ssu.ac.ir/article-1-321-fa.html
Type of Aerobic Training Effect on Cardiac Muscles MIR29A and Collagen I Gene Expression in Diabetic Male Rats. دیابت و چاقی. 1395; 8 (4) :183-190

URL: http://ijdo.ssu.ac.ir/article-1-321-fa.html


چکیده:   (74 مشاهده)
Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats.
Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups.
Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027).
Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.

 
متن کامل [PDF 227 kb]   (29 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۶/۶/۲۵ | پذیرش: ۱۳۹۶/۶/۲۵ | انتشار: ۱۳۹۶/۶/۲۵

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
کد امنیتی را در کادر بنویسید

کلیه حقوق این وب سایت متعلق به مجله ایرانی دیابت و چاقی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2015 All Rights Reserved | Iranian Journal of Diabetes and Obesity

Designed & Developed by : Yektaweb