Volume 4, Number 3 (volume 4, number 3 2012)                   IJDO 2012, 4(3): 120-126 | Back to browse issues page


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Azizian H, Ebrahim Rezvani M, Esmaeilidehaj M, Bagheri S M. Anti-Obesity, Fat Lowering and Liver Steatosis Protective Effects of Ferula asafoetida Gum in Type 2 Diabetic Rats: Possible Involvement of Leptin. IJDO. 2012; 4 (3) :120-126
URL: http://ijdo.ssu.ac.ir/article-1-94-en.html

Assistant professor of physiology, Department of physiology, school of medicine, Shahid Sadoughi University of medical sciences, Yazd, Iran
Abstract:   (3297 Views)
Objective: Control of weight gain is an important strategy in reducing the diabetes incidence. Recently, herbal drugs have been used as a complementary and alternative medicinal care. This study was conducted to determine the effect of Ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level. Materials and Methods: All rats of control and treatment groups received daily tap water (P.O) as vehicle mixed with fructose 10%. Two treatment groups received FAF oleo-gum resin at doses of 25 or 50 mg/kg (P.O). Normal rats received only tap water and standard chow food. Body weights, abdominal fat, size of epididymal adipocyte and serum leptin were recorded. Result: Administration of Ferula asafoetida significantly decreased body weights, abdominal fat and size of epididymal adipocyte compared to untreated rats (P<0.05). Levels of serum leptin were significantly decreased in treated rats (P<0.05). Conclusion: This study showed that Ferula asafoetida extract has anti-obesity, fat lowering effects and can prevent liver steatosis in type 2 diabetic rats. Reduction of serum leptin is associated with protective effects of Ferula asafoetida in obese diabetic rats.
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Type of Study: Research | Subject: General
Received: 2013/06/18

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