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Showing 15 results for Dehghani

Seyed Khalil Forouzannia, Seyed Mohammad Mohammadi, Seyed Jalil Mirhosseini, Mohammad Hossein Abdollahi, Seyed Hossain Moshtaghion, Habibbolla Hosseini, Seyed Ali Banifateme, Seyed Mehdi Hosseini, Sedigheh Soheilykhah, Dehghanizade Dehghanizade,
Volume 1, Issue 1 (9-2009)

OBJECTIVE: Hyperglycemia is associated with increased morbidity and mortality in diabetic patients following coronary artery bypass grafting. Tight glycemic control in perioperative period can reduce these events. The goal of this study was to determine whether combination of continuous infusion and subcutaneous glargine as a basal insulin could improve glycemic control. MATERIAL AND METHODS: Diabetic patients who were candidate for CABG were randomized to receive continuous insulin infusion with or without subcutaneous Glargine insulin for at least 72 hours which started 24 hours before surgery and continued for 48 hours after surgery. RESULTS: A total 84 subjects were required. In group A (n = 45) continuous insulin infusion was used for glycemic control and in group B (n = 39) we used continuous insulin infusion with sub‌cutaneous glargine insulin. Blood glucose level was significantly better in desirable range in group B in comparison to group A. Total mean blood glucose level in group A was 186.1 mg/dl and in group B was 174.3 mg/dl (P = 0.008). Frequency of hypoglycemia (blood glucose <70 mg/dl) was 0.66% in group A and 0.5% in group B that was similar (P = 0.530). The mean length of stay in the hospital was not different between two groups (P = 0.288). CONCLUSION: We found out that a combination of continuous insulin infusion and glargine insulin as main basal insulin can improve glycemic control in diabetic patients undergoing coronary artery bypass grafting.
Hamideh Dehghani, Fatemeh Heidari, Hassan Mozaffari- Khosravi, Nader Nouri-Majelan, Masoud Rahmanian, Ali Dehghani,
Volume 5, Issue 2 (volume 5, number 2 2013)

Objective: Measurement of glomerular filtration rate (GFR) is the best determinant in assessment of kidney function for diagnostic and therapeutic purposes. As extremely accurate methods of GFR measurement (i.e. Inulin clearance) are expensive and Time-consuming and due to limitations of the 24 hour urine collection method, some formula have been developed for the GFR measurement. Here we have compared the GFR calculated via CG or MDRD formulas and that measured by creatinine clearance in 24-hour urine collection method in diabetes patients with chronic kidney disease (CKD). Materials and Methods: This study was performed on 75 diabetes patients with stage 3 or 4 CKD (15-19 ml/min/1.73m2) in the nephrology clinics of the Yazd medical university. The GFR was measured via CG and MDRD formula and also via creatinine clearance in 24-hour urine collection method. Correlation test and Bland altman plot was utilized to check for the relationship between creatinine clearance and the GFR. Results: Results show a significant correlation of the GFR calculated via creatinine clearance in 24-hour urine collection with GFR calculated via CG (r= 0.75) and with MDRD (r=0.70) formulas. This correlation was even increased when serum levels of creatinine was >1.5 mg/dL or in patients with stage 4 CKD. Comparison of the differences between GFR calculated via CG or MDRD formulas and creatinine clearance in 24-hour urine collection method using Bland altman showed a lower bias (CG: 17.76 MDRD: 10.64 ml/min/1.73 m2) and narrower limits of agreement (MDRD: -11.33 – 32.62, CG: -4.68 – 40.20) to the creatinine clearance in 24-hour urine collection for the MDRD formula compared to that for the CG formula. Conclusion: CG and MDRD correlate well with creatinine clearance in 24-hour urine collection, while MDRD is more accurate in diabetes patients with stage 3 or 4 CKD.
Faezeh Poursoleiman, Hassan Mozaffari-Khosravi, Javad Zavar Reza, Ali Dehghani,
Volume 5, Issue 2 (volume 5, number 2 2013)

Objective: Type 2 diabetes mellitus (DM-2) is a chronic and progressive metabolic disorder known as a serious threatening condition in the individual and society. Type 2 diabetes mellitus is known as the major cause of cardiovascular diseases (CVD). Contradictory evidences about the effect of omega-3 fatty acids on CVD risk factors, particularly hypertension. The aim of this study was to determine the effect of omega-3fatty acids supplementation on blood pressure in DM-2 patients. Materials and Methods: This is a double-blind, placebo-controlled clinical trial on patients referred to Yazd Diabetes Research Center. Seventy DM-2 patients were randomly assigned to receive either 2 g/day omega-3 soft gels (OG) or 2 g/day placebo (PG) for 6 weeks. At the beginning and end of the study, blood pressure was measured and compaired Results: Fifty nine percepts of patients in OG and 41% in PG had hypertension. Initially, there was no significant difference in the mean of age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) and duration of diabetes between two groups. At the end of the study, the mean of SBP, DBP and differences between groups were not significant. Conclusion: Consumption of 2 g/day omega-3 supplement for6 weeks has no significant effect on systolic and diastolic blood pressure in DM-2 patients.
Mohammad Ranjbar Ezzatabadi, Masoud Rahmanian, Elham Jamali, Arefeh Dehghani Tafti,
Volume 5, Issue 2 (volume 5, number 2 2013)

Objective: Type 2 diabetes is amongst the most common chronic illnesses in Iran. Its prevalence is increasing and it has significant economic importance. The aim of this study was to estimate direct therapeutic and non-therapeutic costs of type 2 diabetes Patients Referred to the Diabetes Research Center of Yazd in 2012. Materials and Methods: This cross-sectional study was carried out on 250 type 2 diabetes patients referred to Yazd Diabetes Research Center in 2012. Direct health costs were estimated from costs of physician visit, Nutrition counseling, Anti diabetic agent, Testing, Hospital inpatient care, imaging, wound, Cataract , Physiotherapy, dialysis and other costs included (Insulin ,Test tape), as well as direct costs of non-treatment including Cost of travel and accommodation and required data was gathered by questionnaire. Mann-Whitney Test, Kruskal -Wallis Test and T-test analysis was used to identify the Results. Results: The total estimated cost of 250 type 2 diabetes patients in 2012 is 1369913472 rials, including 1258651472 rials indirect costs of treatment (91.87%) and 111262000 rials indirect non-therapeutic (8.1%). The per capita cost is 5479653 rials .The major parts of medical expenditures are hospital inpatient care (28% of the total medical cost), other cost include Insulin ,Test tape and etc(23% of the total medical cost) , Cataract(10.96% of the total medical cost), imaging (9.77% of the total medical cost),prescription medications to treat the complications of diabetes (8.68%),physician visits (7.04%), Testing (6.31%), dialysis(2.6%), wound(2.1%), Physiotherapy (0.89%) and Nutrition counseling (0.18%). Conclusion: This estimate highlights the substantial burden that diabetes imposes on society. Additional components of societal burden omitted from our study include intangibles from pain and suffering, resources from care provided by nonpaid caregivers, and the burden associated with undiagnosed diabetes.
Samaneh Shojaeii, Ali Dehghani Firoozabadi, Morteza Behnam Rasouli, Naser Mahdavi Shahri, Haghparast Alireza,
Volume 5, Issue 3 (volume 5, number 3 2013)

Abstract Objective: Previous studies have indicated the hyperglycemia-induce cell death in various tissues such as brain, kidneys, liver and especially in the testis. Recent studies have reported that diabetes can trigger male infertility. In this study we report the histological analysis of the testis tissue after diabetes type 1 induction in wistar rats. Materials and Methods: At various time intervals after diabetes type 1 induction, testicular cell was assessed in the controls and in the diabetic rats. Hyperglycemia was induced in male wistar rats by intraperitoneal injection of drug streptozotocin (STZ). At different time points (4, 6, 8 and 20 weeks) post diabetes type 1 induction, rats were euthanized and testicular tissues were removed for histological analysis. Their testes were fixed in formaldehyde (37%), embedded in paraffin and then sectioned (4µm thick). They were further deparaffinized, stained with Hematoxylin-Eosin (H&E) and DAPI, and observed under light and fluorescence microscope, respectively. Results: Histological results showed reduced cell density in testis, which indicates that diabetes type 1 and hyperglycemia conditions impair normal cell density in testis tissue. The changes in seminiferous tubules from 4 weeks to 20 weeks were also observed. The testicular histology of diabetic animals shows that the maximum reduction in cell density occurred after 20 weeks. Conclusion: The induced diabetic condition provides evidence that hyperglycemia plays an important role in pathogenesis of diabetes, and also indicated that chronic hyperglycemia eventually leads to cell death and male infertility. Probably, the consequent of inflammatory condition of hyperglycemia resulted in apoptotic-related gene products and testicular dysfunction which has an important implication for infertility, and offer new chances for therapeutic interventions.
Akram Naghdipour-Biregani, Hassan Mozaffari-Khosravi, Faezeh Poursoleiman, Javad Zavar Reza, Masoud Rahmanian, Ali Dehghani,
Volume 6, Issue 1 (volume 6, number1 2014)

Objective: Patients with metabolic syndrome are prone to cardiovascular disease and diabetes. Regarding the importance of nutritional factors in management of metabolic syndrome, this study was designed to evaluate the effects of dark chocolate consumption on serum lipid profile in patients with metabolic syndrome. Materials and Methods: In this randomized clinical trial, 114 patients with metabolic syndrome, aged 30 to 60 years, without heart, renal and hepatic diseases were recruited. The eligible patients were randomly allocated to receive either dark chocolate (76% purity), 20 or 40 grams daily for two months. Total cholesterol, high-density lipoprotein (HDL), triglycerides (TG) and fasting blood glucose (FBG) were measured with enzymatic methods before and after intervention. A low-density lipoprotein (LDL) level was calculated by the Friedewald formula. Data were analyzed using SPSS version 16.0 and ANOVA test P<0.05 was considered significant. Dietary intake was measured with NUT4 software at the beginning and the end of the study. Results: There were no significant changes in dietary intakes of patients during the intervention in three groups. No significant differences were seen in mean concentration of lipid profile before and after intervention in groups (P>0.05). Conclusion: Consumption of 20-40g/day dark chocolate with 76% purity for 2 months doesn't change the lipid profile of patients with metabolic syndrome.
Mosayeb Fallahi, Hassan Mozaffari-Khosravi, Mohammad Afkhami-Ardekani, Ali Dehghani,
Volume 6, Issue 3 (volume 6, number3 2014)

Objective: Sexual dysfunction is considered as an important health problems. Chronic diseases such as diabetes can have negative effect on sexual function. This study aims to determine the level of sexual dysfunction in male patients with diabetes mellitus type 2 in Yazd Diabetics Research Center. Materials and Methods: This descriptive study involved 69 male patients with type 2 diabetes mellitus in Yazd Diabetes Research Center- 2014. The Questionnaire consisted of two parts: demographic characteristics of patients and the IIEF questionnaire (the International Index of sexual function). Data analysis was performed by using SPSS software version 21, and by using descriptive statistics, mean, standard deviation and statistical tests of Fisher' exact and T-test. Results: The mean of age, height and weight of participants were 51.44 year, 171.14 cm, 77.55 kg, respectively. Through 15 items surveyed, lowest mean is related to the question attempted to intercourse (1.20±0.40) and the highest average related to the question marriage satisfaction (3.50±0.50). Conclusion: According to the results, most of the participants were in trouble in making erection and frequency of intercourse. Informing the patient as the first and most effective ways of prevention and treatment is essential.
Roya Khajeh-Mehrizi, Hassan Mozaffari-Khosravi, Akram Ghadiri-Anari, Ali Dehghani,
Volume 6, Issue 4 (volume 6, number4 2014)

Objective: Diabetes is a common endocrine disorder caused by deficiency of insulin secretion or insulin resistant. nowadays, in addition to trying to find a safe way to control diabetes, find the low side effect way is important. This study was designed to find the effect of Urtica dioica extract on glycemic control and insulin resistance in patients with type 2 diabetes. Materials and Methods: A parallel randomized clinical trial was conducted with participating 60 patients with type 2 diabetes who met inclusion criteria were recruited. Patients were randomly assigned to receive 100mg/kg/day extract of Urtica dioica group (UG) and the other group which received placebo (PG) over an 8 weeks period. Fasting blood sugar (FBS) concentration and insulin resistance indices (insulin concentration, insulin resistance (IR), insulin sensitivity (S%) and β-cell function (β%)) were measured at baseline and end of the study. Data were analyzed using SPSS 16.0 and P<0.05 was considered significant. Results: The mean difference of FBS in UG and PG were 20.16±52.6 mg/dl and -0.7±45.29 mg/dl (P-value=0.14) and the mean concentration of insulin in UG and PG were 2.5mU/L and 0.2mU/L (P-value=0.003), respectively, that showed a significant increase in insulin concentration in UG compared to PG and the mean IR in UG and PG were 0.3 and 0.1 (P-value=0.01) that showed a significant decrease in IR in UG compared to PG. The mean difference of β% in UG and PG were -24.16±35.07% and 1.22±18.14% (P-value=0.003), and the mean difference of S% in UG and PG were -54.72±69.3% and 1.1±74.01% (P-value=0.009), respectively that showed increase in insulin concentration, β% and S% and decrease in IR in UG compared to PG. Conclusions: In the present study we demonstrated that consumption of 100mg/kg/day extract of U.dioica for 8 weeks did not have significant effect on FBS and it has significant effect on insulin resistance indices.
Ali Fattahi Bafghi, Mohammad Afkhami-Ardekani, Arefeh Dehghani Tafti,
Volume 7, Issue 1 (volume 7, number1 2015)


Objective: Diabetes is now known as one of the chronic diseases that besides body have negative effects on the psychological status of patients and it is one of the predisposition diseases which can lead to opportunistic infection like pathogens parasites. The aim of present study was Frequency distribution of intestinal parasitic infections in diabetic patients – in Yazd.

Materials and Methods: This descriptive and cross sectional study was performed on 500 stool samples of Diabetic patients and healthy individuals with cluster random sampling in Yazd diabetes research centers from December 2012 to December 2013. Stool samples were collected, fixed and examined by Formalin- ether method (FEM) for detecting pathogen.

Results: In this study 500 stool samples [250 (92 men and 158 women) from control and 250 (91 men and 159 women) from diabetic patients] were collected. The results of this study indicated that intestinal parasites rate in diabetic patients is higher (61:24.4%) than healthy control group (58:23.2%).

Conclusion: The results showed a high prevalence of risk factors for diabetes complications and intestinal parasitic. Due to in Immunocompromised patients, it need for establishment of Diagnostic methods are emphasized.

Ali Dehghani Firoozabadi, Samaneh Shojaeii, Alireza Haghparast, Hamidreza Dehghani Firoozabadi,
Volume 7, Issue 1 (volume 7, number1 2015)


Objective: The previous studies indicated that the TLRs especially Toll-like receptor 4) TLR4 (are involved in the process of diabetes. The aim of the present research was to investigate the time course expression pattern of TLR4-a main component of innate immune system- in mRNA levels in the heart tissue of diabetic male wistar rats.

Materials and Methods: In this research, adult Wistar rats (6-8 weeks old and 200-250 g weight) were mated and the pups were grown to 6-8 weeks old. Heart tissues were collected and analyzed by real-time PCR to evaluate the mRNA levels of TLR4. The mRNA levels of TLR4 in total heart tissue were evaluated in STZ-treated control rats in various times after diabetes induction.

Results: Results showed that the up-regulation of TLR4 during the time course after diabetes induction as compared to the control. The abundant expression of TLR4, a major component of innate immunity system, provides strong evidence that TLRs play important roles in the pathogenesis and expansion of diabetes and it is possible that the expression of TLRs eventually lead to cardiovascular disease.

Conclusion: The abundant expression of TLR4 which is major component of innate immunity system, provides strong evidence that TLRs play important roles in innate immunity and the pathogenesis and expansion of diabetes. It is possible that the expression of TLRs eventually lead to cardiovascular disease. The mechanisms for the increase in TLR expression and activity in diabetes have not been studied in depth. Modulating these TLRs could be beneficial in prevention of diabetic complications.


Azam Ghaneei, Safar Ali Dehghani, Azimeh Kadkhodazadegan Yazd, Mahmood Vakili,
Volume 7, Issue 3 (volume 7, number3 2015)

Objective: In patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. We designed a study for comparing the level of Ox-LDL in diabetic patients with Macro-albuminuria, Micro-albuminuria, versus Normo-albuminuric.

Materials and Methods: One hundred and thirty five patients with type 2 diabetes mellitus who had been referred to the Yazd Diabetes Clinic, from 1391 through 1392, were enrolled to our study. The 24 hours urinary albumin excretion was measured and Macro-albuminuria defined as albumin excretion of greater than 300mg per day and below 30mg per day in normo-albuminuric group and between 30-300mg defined as Micro-albuminuria group. Plasma level of OX-LDL was measured.

Results: The plasma OX-LDL level in patients with Macro-albuminuria was higher than those in Normo-albuminuric group, (16.1±3.6 U/ml versus 8.6±1.7 U/ml). There was a significant correlation between the OX-LDL and urine albumin in Macro-albuminuria and Micro-albuminuria groups. There was no significant correlation between the OX-LDL and HbA1C level and diabetes duration.

Conclusion: Significantly elevated plasma OX-LDL in patients with Macro-albuminuria suggests that OX-LDL may play an important role in the progression of diabetic nephropathy.

Elham Adelnia Najafabadi, Ali Dehghani, Saeed Behradmanesh, Azadeh Najarzadeh,
Volume 7, Issue 4 (volume 7, number4 2015)

Objective: Nonalcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease in the world and it is one of the liver transplantation causes. The present study aimed to investigate the effect of Purslane seeds on anthropometric parameters, fasting blood glucose (FBS), and liver enzymes in patients with nonalcoholic fatty livers.

Materials and Methods: in this clinical trial, 54 patients with fatty livers were participated and randomly divided into two groups: the 1st group received 10 grams of purslane seeds per day along with a weight loss diet and the 2nd (control) group were only engaged in a weight loss diet. At the beginning and at the end of the 8th week of intervention, anthropometric parameters, FBS, liver enzymes and liver sonography were studied in both groups.

Results: After the intervention, significant reductions in weight, waist and hip circumference (P=0.01) were observed in both groups, but only the changes in hip circumference were significant between the two groups (P=0.01). Body mass index significantly reduced only in the purslane group (P<0.05). The average intake of energy, protein, carbohydrate, and fat was reduced in both groups (P<0.05). No significant changes occurred in the fasting blood glucose before and after the study in both groups; however, FBS was significantly different after 8 weeks compared with the control group (P<0.05). Purslane consumption after 8 weeks significantly reduced alanine aminotransferase (P=0.03) and aspartate aminotransferase (P=0.03) in the relevant group; yet the changes were not significant in the control group. Diet and purslane consumption were unaffected on alkaline phosphatase (ALP) levels. In both group liver steatosis decreased but in the purslane group was more significant.

Conclusion: This study showed that consumption of purslane seeds besides the diet for 8 weeks have beneficial effects on anthropometric parameters, FBS, liver enzymes and liver steatosis. Purslane consumption significantly reduced alanine aminotransferase and aspartate aminotransferase. Liver steatosis decreased in the purslane group more than control group.

Zeinab Yazdanpanah, Akram Ghadiri-Anari, Alireza Vahidi Mehrjardi, Ali Dehghani, Azadeh Nadjarzadeh,
Volume 8, Issue 1 (volume 8, number 1 2016)

Objective Diabetes mellitus (DM) as a metabolic disorder is becoming a serious threat of health. In recent years, there has been renewed interest in the treatment against different diseases using medicinal plants. The present randomized clinical trial was carried out to evaluate the efficacy of Ziziphus in improving glucose control in women with type 2 diabetes mellitus (T2DM).

Materials and Methods: Women were randomized to treatment with Ziziphus (30 gr/day) or control group (age match). This trial was done during three months. Fasting blood sugar (FBS), 2-hour postprandial blood glucose (2hpp) and glycated hemoglobin (HbA1c) were measured before and after the intervention.

Results Ziziphus consumption was associated with significant reductions in serum levels of 2hpp glucose and HbA1c (P<0.05) in women with T2DM. As well as marginally significant effect was observed from Ziziphus of serum levels of FBS (P=0.06) after the intervention.

Conclusion: Consumption of Ziziphus for 3 months has anti-diabetic effects on women with T2DM. These findings suggest Ziziphus as a beneficial supplement for diabetic women.

Mohammad Reza Fatahi Ardakani, Ali Reza Vahidi, Elham Karimi-Nazari, Ali Dehghani, Azadeh Nadjarzadeh,
Volume 8, Issue 4 (volume 8, number 4 2016)

Objective: There are association between oxidative stress and incidence of some chronic diseases, such as type 2 diabetes mellitus (T2DM). Food containing antioxidant compounds, such as some spices, are the natural ways to deal with oxidative stress. The purpose of this study was to determine the effect of sumac powder (Rhus coriaria L) on the glycemic profile in patients with T2DM.
Materials and Methods: In this experimental study, 60 T2DM patients were selected and randomly divided into two groups: intervention and control groups. The intervention group received 2 packs of 3 grams sumac powder once a day for 3 months in two bowls of low-fat yoghurt for lunch and dinner and the control group received two bowls of low-fat sumac-free yoghurt  for lunch and dinner. Data collection was performed by a checklist at the beginning and end of the study and blood samples were collected. Data were analyzed using paired T-test and independent t-test. The significance level was considered at P<0.05.
Results: In this study, the fasting serum insulin levels decreased in the intervention group. But the mean changes of variables were not statistically significant between two groups. There was also no difference in other factors between the beginning and end of the study.
Discussion: This study showed that daily intake of 6 grams sumac powder for three months had no significant effect on the glycemic profile (fasting blood sugar and 2-hours post-prandial glucose and glycosylated hemoglobin A1C) and serum insulin levels of diabetic patients.

Zahra Rahvarzadeh, Mehran Dehghanian, Mohammad Yahya Vahidi Mehrjardi, Mahmood Dehghani Ashkezari,
Volume 14, Issue 1 (volume 14, number 1 2022)

Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and insulin secretory defect. Deficiency of cellular immunity is known as one of the factors involved in the pathogenesis of T2DM. lymphocyte-specific protein tyrosine kinase( LCK) is an important gene involved in the intracellular signaling pathways of lymphocytes. This study aimed at determining and comparing LCK gene expression levels in diabetic patients compared with the healthy controls.
Materials and Methods: In this case-control study, 60 people, including 30 T2DM and 30 healthy people were included. The expression levels of the LCK gene were measured by real-time polymerase chain reaction and the obtained data were analyzed by T-test in GraphPad Prism6 software.
Results: The expression level of the LCK gene was increased in diabetic samples compared with the healthy samples (P= 0.0001).
Conclusion: The results suggested that changes in the expression levels of LCK gene can play a role in the pathogenesis of T2DM.

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