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Fereshteh Shahidi, Faramarz Yazdani, Abbas Ali Gaeini,
Volume 12, Issue 2 (volume 12, number 2 2020)
Abstract

Objective: The equilibrium of angiogenesis stimulus agents and angiogenesis inhibitory agents is an important factor in the increase of diabetic cardiomyopathy. This research aimed to survey the result of eight weeks of high-intensity interval training (HIIT) and moderate continuous (MICT) on the myocardium angiogenesis agent and histological alterations within male diabetic rats.
Materials and Methods: 32 male Wistar rats did casually selected within 4 groups: health without exercise control, diabetic without exercise (D), D + HIIT, and D+ MICT groups. Diabetes type 2 produced with high-fat food for two weeks and an only dose of STZ. After approval of type 2 diabetes, subjects did direct to HIIT (90 -95 percent of VO2max), and MICT (50 to 65 percent of VO2max) exercise program five times per week during eight weeks. Western blotting methods were utilized for the exposure of protein synthesis of Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-beta (TGF-β1), and Matrix Metalloproteinase-9 (MMP9) in the left ventricle. Besides, the base and ultimate blood glucose were estimated. Histological alterations assessed utilizing H&E and Masson’s trichrome staining.
Results: The installation of diabetes develops TGF-β1 (P-value= 0.001) and reduces MMP9 (P-value= 0.002) and VEGF (P-value= 0.002). But, eight weeks of MICT enhanced MMP9 (P-value= 0.002) and VEGF (P-value= 0.002), but the volume of TGF-β1 (P-value= 0.001) diminished significantly. Furthermore, the MICT did improve better than of HIIT in improving angiogenesis agents and adjust body mass, plasma glucose in the rats with diabetes.
Conclusion: Not only eight weeks of interval and continuous exercise enhanced levels of MMP9 and VEGF, but also revealed a notable reduction in TGF-β1. Additionally, both training diminishes body weight and blood sugar.
Behroz Khodayari, Mohammad Reza Dehghan, Reza Nouri, Abbas Ali Gaeini, Mohammad Reza Kordi,
Volume 14, Issue 3 (volume 14, number 3 2022)
Abstract

Objective: Evaluation of the effect of 8 weeks of High-Intensity Interval Training (HIIT) on the serum level of cardiac troponin T (cTnT) in sedentary obese young men.
Materials and Methods: Thirty sedentary men were randomly divided into 3 groups: the 30s HIIT training group (n=10), the 60s training group (n=10), and the control group (no exercise) (n=10). Interval training with 90 %VO2peak was done in 3 sessions for 8 weeks. cTnT was measured 5 times; pre-exercise, 4hrs, and 24hrs after the first session (4hF, 24hF), and 4hrs and 24hrs after the last training session (4hL, 24hL). ANOVA with repeated measures and Bonferroni post-hoc tests were used by SPSS 23 with a significance level of (P< 0.05).
Results: The significant increase in serum levels of cTnT in the post-tests of the 60s HIIT compared to the first 24hrs and the last 24hrs (P= 0.0001). But in the 30s group it was not significant compared to the other measurements (P≥ 0/05). In the 2 training groups, serum levels of cTnT in the last 4hr post-tests of the last week were not significantly different from the 4hrs post-tests of the first week (P≥ 0.05).
Conclusion: It seems that none of these activities cause heart damage sustained, and changes in cTnT levels in two 4hrs compared to the first and last 24hrs of the 60s group may be due to reversible leakage of cardiac cell membranes, and may continuous exercise will reduce this reduction.
 

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