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Showing 12 results for Ghadiri-Anari

Akram Ghadiri-Anari, Majid Jafarizadah, Asghar Zare, Hassan Mozaffari-Khosravi, Mohammad Afkhami-Ardekani, Ahmad Shojaoddiny-Ardekani,
Volume 5, Issue 2 (volume 5, number 2 2013)

Objective: Obesity is a worldwide and major public health problem including Iran and other countries. Available data indicates that the prevalence of obesity has significantly increased among the Iranian population over the past 30 years. The aim of the present study was to evaluate the prevalence of obesity in Yazd (central province of Iran) population. Materials and Methods: This was a cross-sectional population-based study and performed by census method on Yazd population aged 30 years old or above. Height, body weight and Body Mass Index (BMI) were measured. Statistical analyses were performed with Chi-Square test. Results: Totally, 8448 subjects aged>30 years from both sexes were evaluated. Data showed that the rate of BMI above 25kg/m2 for women and men was 43.9% and 32.2% respectively. In both genders, the rate of obesity and overweight raised by increasing of age up to 50 years old. Overall, the prevalence of obesity was higher in women compared with men in all ages. The prevalence of obesity and overweight were 9.5% and 29%, respectively. Conclusion: This study indicated a high prevalence of obesity and overweight in the central area of Iran, especially in urban people.
Akram Ghadiri-Anari, Amir Hossein Jafari-Mehdiabad, Mohammad Afkhami-Ardekani, Mahboobeh Rezapour, Fahimeh Chavoshzadeh-Tafti,
Volume 5, Issue 4 (volume 5, number 4 2013)

Abstract Objective: Patients with type 2 diabetes mellitus (DM) have a markedly increased risk of cardiovascular morbidity and mortality. There are some recommendations for prescription of aspirin in these patients. Our purpose was to determine aspirin usage rate in diabetic patients and to compare it in different ages and based upon cardiovascular disease (CVD) risk factors. Materials and Methods: In this study we collected data from 1256 self-reported diabetes mellitus patients referred to Yazd Diabetes Research Center during 2010-2011. This data included age, sex, history of diabetes mellitus, drug history, antiplatelet therapy duration, smoking, hypertension, dyslipidemia, family history of premature CVD and albuminuria. Results: 48.5% of patients were male (609 patients) and 51.5% were female (647 patients). From female patients ≤60 years old, 52.7% used antiplatelet drug however, this percent for patients over 60 years was 58.9% and for male patients ≤50 and >50 was 47.7% and 81%, respectively. From antiplatelet drug users, 43.1% of males aged ≤50 and 29.2% of females aged ≤60 years old had no or one risk factor that is unnecessary to take it. Conclusion: Physician must encourage diabetic patients to use aspirin when the potential benefit of a reduction in cardiovascular disease outweighs the potential harms. So, clinical judgment is required for prescription of aspirin in men aged ≤ 50 years and women aged ≤ 60 years without multiple risk factors.
Roya Khajeh-Mehrizi, Hassan Mozaffari-Khosravi, Akram Ghadiri-Anari, Ali Dehghani,
Volume 6, Issue 4 (volume 6, number4 2014)

Objective: Diabetes is a common endocrine disorder caused by deficiency of insulin secretion or insulin resistant. nowadays, in addition to trying to find a safe way to control diabetes, find the low side effect way is important. This study was designed to find the effect of Urtica dioica extract on glycemic control and insulin resistance in patients with type 2 diabetes. Materials and Methods: A parallel randomized clinical trial was conducted with participating 60 patients with type 2 diabetes who met inclusion criteria were recruited. Patients were randomly assigned to receive 100mg/kg/day extract of Urtica dioica group (UG) and the other group which received placebo (PG) over an 8 weeks period. Fasting blood sugar (FBS) concentration and insulin resistance indices (insulin concentration, insulin resistance (IR), insulin sensitivity (S%) and β-cell function (β%)) were measured at baseline and end of the study. Data were analyzed using SPSS 16.0 and P<0.05 was considered significant. Results: The mean difference of FBS in UG and PG were 20.16±52.6 mg/dl and -0.7±45.29 mg/dl (P-value=0.14) and the mean concentration of insulin in UG and PG were 2.5mU/L and 0.2mU/L (P-value=0.003), respectively, that showed a significant increase in insulin concentration in UG compared to PG and the mean IR in UG and PG were 0.3 and 0.1 (P-value=0.01) that showed a significant decrease in IR in UG compared to PG. The mean difference of β% in UG and PG were -24.16±35.07% and 1.22±18.14% (P-value=0.003), and the mean difference of S% in UG and PG were -54.72±69.3% and 1.1±74.01% (P-value=0.009), respectively that showed increase in insulin concentration, β% and S% and decrease in IR in UG compared to PG. Conclusions: In the present study we demonstrated that consumption of 100mg/kg/day extract of U.dioica for 8 weeks did not have significant effect on FBS and it has significant effect on insulin resistance indices.
Amir Hossein Jafari-Mehdiabad, Akram Ghadiri-Anari, Hassan-Ali Vahedian-Ardakani, Narjes Nazemian,
Volume 7, Issue 1 (volume 7, number1 2015)


Objective: Obesity is related to anemia which is explained its mechanism as disorder in iron absorption but the more rational reason is anemia of inflammation or anemia of chronic disease. The aim of this study was to define the prevalence of obesity in patients with normochromic normocytic anemia.

Materials and methods: We screened 406 patients who were referred to endocrine clinic. They were excluded from study if suffering from malignancy, hypo or hyperthyroidism, diabetes, growth hormone disorder, rheumatologic disorder or corticosteroid consumption. The complete blood count were checked in each participants. The patients with normochromic, normocytic anemia were diagnosed. Data was analyzed by SPSS17 software.

Results: Among this population, 26 persons had normochromic, normocytic anemia and 11 (42.3%) patients had central obesity. In remainder of persons (Without normochromic, normocytic anemia), 58.4% had central obesity.Overall, 49 patients had anemia and central obesity together. About 53% of them had normochromic normocytic anemia.

Conclusion: Central obesity is a common and complex phenomenon which is due to multiple etiologies. But based on our study, although the prevalence of central obesity was lower in patients with normochromic normocytic anemia, in 42.3% of them there was no source of inflammation except central obesity. Most patients with anemia and central obesity had normochromic normocytic anemia.

Akram Ghadiri-Anari, Amirhossein Jafari-Mehdiabad, Mansour Moghimi, Hamid Hoboubati, Mohammad-Hosein Panahbekhoda,
Volume 7, Issue 3 (volume 7, number3 2015)

Objective: Lumbar spinal canal stenosis (LSCS) has prominent position in spinal disorders of the elderly. Ligamentum flavum hypertrophy plays a dominant role in narrowing of the LSCS. There are some clues that Ligamentum flavum hypertrophy is associated with diabetes mellitus. Our objective was comparison of histological properties of ligamentum flavum in Lumbar spinal canal stenosis patients with and without diabetes mellitus.

Materials and Methods: In this case control study, during 9 months, twenty-nine patients, who were candidate for decompressive laminectomy because of ligamentum flavum hypertrophy, were studied. They were labeled as diabetic if had history of diabetes mellitus or fasting blood sugar ≥126mg/dl for two times or blood sugar >200mg/dl anytime with symptom of hyperglycemia. Ligamentum flavum was removed through surgery. Samples were evaluated by pathologist using Hematoxylin &Eosin, Masson’s trichrome and Verhoeff van Gieson staining. Evaluation includes grading of fibrosis, loss of elastin fibers, calcification and number of cellularity of samples. Data analyzed with Fisher’s test and Mann-Whitney test.

Results: In this study 41% of patients (12 persons) were suffering from diabetes mellitus. There was no significant difference between diabetic and nondiabetic patients in histological properties. (P>0.05); but the weight of diabetic patients was higher than nondiabetics (P-value =0.038)

Conclusion: These results show that diabetes mellitus has no effect on histological change in ligamentum flavum of spinal canal stenosis and mechanical stress (due to overweight) has a more important role in pathogenesis of spinal canal stenosis.

Hamid Hoboubati, Akram Ghadiri-Anari, Hamed Hushang-Malamiri,
Volume 7, Issue 4 (volume 7, number4 2015)


Objective: Diabetes mellitus (DM) is a systemic disease affecting different tissues. Hyperglycemia due to DM can lead to degenerative changes in spinal tissue. Also low data have examined the prevalence of diabetes mellitus in lumbar spinal canal stenosis individuals. Therefore the purpose of this study was determining the frequency of DM in lumbar spinal canal stenosis patients.

Materials and Methods: A cross-sectional study on 119 lumbar spinal canal stenosis patients, since September 2014 till February 2015 from the department of neurosurgery in Rahnamoon hospital of Yazd, Iran was done. After gathering of demographic data, these subjects divided in two groups based on present or absent of DM. The latest criteria established by the American Diabetes Association (ADA) were used to diagnose DM patients.

Results: The frequency of DM among lumbar spinal canal stenosis patients was 22.7 %. The frequency of DM was higher in women than men that there was significant difference in the diabetic and non-diabetic patients (P=0.002). Also the mean age of diabetic patients was higher than non-diabetic patients (P=0.036). Diabetes was more prevalent in patients older than 50 years old.

Conclusion: According to our findings, the frequency of DM among lumbar spinal canal stenosis patients was high that may be a probably predisposing factor for the development of significant lumbar disc disease in this region. Also other factors may help to develop lumbar spinal stenosis.

Zeinab Yazdanpanah, Akram Ghadiri-Anari, Alireza Vahidi Mehrjardi, Ali Dehghani, Azadeh Nadjarzadeh,
Volume 8, Issue 1 (volume 8, number 1 2016)

Objective Diabetes mellitus (DM) as a metabolic disorder is becoming a serious threat of health. In recent years, there has been renewed interest in the treatment against different diseases using medicinal plants. The present randomized clinical trial was carried out to evaluate the efficacy of Ziziphus in improving glucose control in women with type 2 diabetes mellitus (T2DM).

Materials and Methods: Women were randomized to treatment with Ziziphus (30 gr/day) or control group (age match). This trial was done during three months. Fasting blood sugar (FBS), 2-hour postprandial blood glucose (2hpp) and glycated hemoglobin (HbA1c) were measured before and after the intervention.

Results Ziziphus consumption was associated with significant reductions in serum levels of 2hpp glucose and HbA1c (P<0.05) in women with T2DM. As well as marginally significant effect was observed from Ziziphus of serum levels of FBS (P=0.06) after the intervention.

Conclusion: Consumption of Ziziphus for 3 months has anti-diabetic effects on women with T2DM. These findings suggest Ziziphus as a beneficial supplement for diabetic women.

Mahmood Vakili, Akram Ghadiri-Anari, Ahmad Azizollahi, Maryam-Sadat Torabipour,
Volume 8, Issue 1 (volume 8, number 1 2016)

Objective: The high prevalence of Gestational Diabetes Mellitus (GDM) in Iran and its maternal and fetal consequences as well as the high risk of its long-term effects including obesity is known. The aim of this study was to evaluate the relationship between body mass index (BMI) in ages of 18 months and 6 years and maternal glucose concentration.

Materials and Methods: This is a retrospective cohort study conducted on 199 pairs of mother and child in five health-care centers of Yazd. The children born in 2007 and 2008 were selected, followed by a calculation of BMI in the ages of 18 months and 6 years (school age) based on their heights and weights recorded in their family files. The relationship between the resulting BMI and maternal glucose concentration and pregnancy conditions was then determined.

Results A population of 199 mother-child pairs were investigated consisting of 105 male children (52.8%) and 94 female ones (47.2 %). The mean (±SD) glucose challenge test (50 gram -GCT) and pre-pregnancy BMI were 121(25.7) mg/dL and 24.16 (4.85) kg/, respectively. At 18 months, the mean (±SD) child BMI was 15.78 (1.21) kg/, 5.5% of which were overweight/obese and at 6 years, the mean (±SD) child BMI was 14.46 (1.81) kg/, 12.6% of which were overweight/obese. This study revealed a significant association between BMI 18 months and 6 years and pre-pregnancy BMI with maternal GCT (P-value <0.003). Therefore, GCT ≥ 130 mg/dL compared with GCT <129 mg/dL significantly associated with BMI at 18 months and 6 years old and the mother's pre-pregnancy BMI.

Conclusion: According to this study, it can be concluded that there is a significant correlation between GCT and the increase of children BMI. It is necessary to control and treat gestational diabetes mellitus by means of decrease the intergenerational cycle of obesity and diabetes in offspring. Also infants of women with diabetes should be specifically targeted for obesity prevention programs.

Mehdi Moeini, Reza Soleimanizad, Akram Ghadiri-Anari, Masoud Reza Manaviat, Farimah Shamsi, Masoud Rahmanian,
Volume 8, Issue 4 (volume 8, number 4 2016)

Objective: Retinopathy is a microvascular complication of diabetes in the retina. It is hypothesized the aqueous flow decrease in patients with retinopathy which effects the Intra-ocular pressure (IOP). The purpose of this study is to determine whether a significant correlation exists between IOP and diabetic retinopathy grades.
Materials and Methods: Our study is analytic cross sectional. About 413 type 2 diabetic patients were studied. They were between 40 to 70 years and did not have glaucoma. They were examined in the ophthalmologist’s clinic and grading of retinopathy was done. IOP was recorded in each cases. Data was then analyzed in SPSS.
Results: Of the 413 type 2 diabetic patients, 329 were diagnosed with diabetic retinopathy and 84 without diabetic retinopathy. There was no significant difference between the mean IOP of patients with diabetic retinopathy and without diabetic retinopathy (P-value=0.53). Also there was no significant difference between the diabetic retinopathy grades. (P-value=0.07).
Discussion: In conclusion, our findings showed that there was no a significant correlation between IOP and grade of diabetic retinopathy.

Samira Hajimaghsoodi, Akram Ghadiri-Anari, Fahimeh Rashidi-Meybodi, Zahra Jafarzadeh,
Volume 9, Issue 4 (volume 9, number 4 2017)

Objective: Diabetes mellitus has multiple effects on oral tissues. Oral symptoms especially periodontal disease and recurrent bacterial and fungal infections seem to vary in patients with different body mass index. The aim of this study was to investigate periodontal treatment needs Index in patients with uncontrolled type 2 diabetes and its relation with body mass index (BMI).
Materials and Methods: In this cross-sectional analytical study, 150 individuals with uncontrolled type 2 diabetes referred to Yazd Diabetes Research Center in 2016 were studied in terms of BMI and the Community Periodontal Index of Treatment Needs (CPITN). Patients divided in two groups: BMI of over 30 and under 30. Data obtained from each group analyzed using SPSS software version 16 and Mann-Whitney statistical test was used.
Results: The mean of CPITN index was not significantly different in men and women. Also in different age groups, there were no significant differences, except 50 to 59 years range. In this age group, the mean of CPITN in patients with BMI above 30 was 1.926 and in BMI under 30 was 1.5792 (P-value:0.019). In patients with BMI above 30 the mean of CPITN reported 1.88 in comparison with 1.61 in group with BMI under 30 (P-value:0.030).
Conclusion: The results indicated that diabetic patients with a BMI greater than 30 need more periodontal treatment than patient with BMI less than 30. Also indexes in the age range 50 to 59 years was more prominent which means clinicians have to consider patients with uncontrolled type2 diabetes more carefully for providing oral health when BMI and age are increasing.

Akram Ghadiri-Anari, Khatereh Kheirollahi, Narjes Hazar, Nasim Namiranian, Maryam Jalili Sadrabad, Mohsen Akhondi-Meybody, Mina Askari Mayani,
Volume 12, Issue 2 (volume 12, number 2 2020)

Objective: Diabetes Mellitus (DM) is one of the most common endocrine diseases with many systemic complications such as oral manifestations. The present study aimed to compare the oral manifestations frequency in diabetic patients and healthy subjects.
Materials and Methods: This cross sectional study was conducted during 2016-17 on subjects came to Yazd Diabetic Research Center. In this study, 181 type 2 diabetic patients (T2DM) and 181 healthy individuals, based on convenient sample method, were included. Two groups were compared for basic information and oral manifestations including candidiasis, oral lichen planus (OLP), periodontitis, xerostomia, delayed oral wound healing, geographic tongue, gingival hyperplasia, fissured tongue, burning mouth and finally at least one of these lesions.
Results: The frequency of candidiasis, OLP, periodontitis, delay oral wound healing, geographic tongue, xerostomia and at least one of lesions in diabetics were significantly higher than control group (P-value< 0.001). After regression analysis and adjusting for confounding factors, candidiasis, periodontitis and xerostomia in diabetics were significantly more prevalent than non-DM patients with odds ratio of 15.16 (1.80-127.57), 9.58 (4.68-19.63) and 78.639 (10.05-615.231) respectively.
Conclusion: Xerostomia, candidiasis and periodontitis were significantly more prevalent in T2DM than Non-T2DM persons. Therefore, increasing awareness on oral manifestations in this group is recommended for timely diagnosis and referring to an oral medicine.
Akram Ghadiri-Anari, Saeedeh Jam-Ashkezari, Bahareh Fallah-Tafti, Masoud Rahmanian, Maryam Dehghan, Nasim Namiranian,
Volume 12, Issue 4 (volume 12, number 4 2020)

Objective: Oxidative stress plays an important role in the onset and progression of diabetic nephropathy. So antioxidant agents may be one of the key treatment strategies for prevention of diabetic nephropathy progression .The aim of this study was to determine the effect of selenium (Se) on micro-albuminuria in type 2 diabetic (T2DM) patients.
Materials and Methods: This study was a clinical study on 60 T2DM patients with micro-albuminuria who were referred to Yazd diabetic research center from March 2016 till April 2017. Patients were randomized in to two groups: Se (200 microgram Se daily) and control. The control group did not receive placebo. The intervention duration was 12 weeks. Micro-albuminuria, fasting blood sugar (FBS), cholesterol, triglycerides, HDL-C, LDL-C, urea, creatinine, HbA1c, plasma Se concentration were measured at the baseline and after 12 weeks. 
Results: Micro-albuminuria decreased after 12 weeks in both studied groups but it was not statistically significant. Cholesterol and LDL levels improved statistically in both studied groups at the end of study (P-value: 0.034, 0.023 respectively). Plasma Se level increased in intervention group (P-value< 0.001). There were clinically improvement in other studied variables after 12 weeks in two studied groups but not statistically significant
Conclusion: Our study demonstrated that Se supplementation for 12 weeks among patients with micro-albuminuria had no beneficial effects on micro albuminuria.

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