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Showing 11 results for Homaee

Abdol-Majid Emami, Hasan Matin Homaee, Mohammad Ali Azarbayjani,
Volume 8, Issue 3 (volume 8, number 3 2016)
Abstract

Objective: The purpose of the present study was investigation of eight weeks high intensity interval (HIIT) along with curcumin supplementation on liver Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration among diabetic male rats.
Materials and Methods: Thirty-two male mice were divided to four groups of control-diabetic, exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic. Eight weeks’ aerobic training schedule was five weekly sessions for the two exercise groups, which each session executed on animal treadmill with speed of 24 (m/min), steep of 0°, and entire span of 18 min. The two supplementary groups were being fed daily amount of 50 (mg/kg) curcumin supplementary, by using the gavage technique. The rats were killed and liver tissues were separated, after the eight weeks’ schedule. Thereafter, in order to study variations of GPX and MDA enzymes, Kits of Zelbio Co. were implemented.
Results: Activity levels of GPX enzyme and MDA concentration of the three groups of exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic in order increased and decreased than those of the control-diabetic one, significantly (P≤0.05).
Discussion: both exercise and curcumin can be recommended as effective interventions on improvement of Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration of the liver, in diabetic condition.
Abbas Fattahi Bafghi, Hasan Matin Homaee, Mohammad Ali Azarbayjani,
Volume 8, Issue 3 (volume 8, number 3 2016)
Abstract



Objective: Exercise and herbs can possess synergistic effects to control diabetes side-effects. The purpose of the present study was to investigate the effects of high intensity interval training (HIIT) and curcumin supplement on activity levels of superoxide dismutase (SOD) and catalase of heart tissue in diabetic rats.
Materials and Methods: Thirty-two male Wistar rats were randomly divided in to four groups of curcumin, training-placebo, training-curcumin and control. The subjects were trained to do HIIT on treadmill and in the fashion of increasing manner. Diabetes was induced via injection of 50 (ml/Kg rat weight) STZ. Fifty (ml/kg rat weight) curcumin was nourished to the animals of the curcumin groups, by using the gavage technique during eight weeks (five days a week). The rats were anesthetized via intraperitoneal injection of ketamine, 24 hrs after the intervention. Then heart tissues were separated from bodies of the rats to examine changes in SOD and catalase enzymes.
Results: Activity levels of SOD and CAT enzymes of the three groups of curcumin, training-placebo, and training-curcumin increased significantly more than control group. But no significant difference was observed between those first three groups (P≤0.05).
Discussion: The results of the present study indicated that either HIIT or taking curcumin supplement could solely contribute significant enhancement to activity levels of antioxidant enzymes within heart tissues of diabetic mice. Though, those two interventions would not strengthen the influences of each other.
Hossein Kalhor, Maghsoud Peeri, Hasan Matin Homaee, Mojtaba Izadi,
Volume 9, Issue 1 (volume 9, number 1,2 2017)
Abstract

Objective: GLUT4 glucose transporter content and glucose transport capacity are closely correlated in muscle. The purpose of current study was to evaluate the effect of 6 weeks of resistance training and High-Intensity Interval Training (HITT) on Glut-4 gene expression in type 2 diabetes mellitus (T2DM) by high fat diet and STZ.
Materials and Methods: This study was done on 32 male Wistar in Baqiyatallah University of Medical Sciences-Tehran. The study sample consisted of 32 male Wistar 10 week old weighting 220 ± 20 gr which were divided into 4 obese groups. One diabetic group had to do resistance training and another group did HIIT. One more diabetic group and the healthy group did not do any activities. At the end, the amount of their left ventricular GLUT-4 was measured. Independent t-test and one way ANOVA were used to examine the results.
Results: The expression of Glut-4 in the left ventricle of diabetic rats was 0.72 lower than that of the non-diabetic group, due to T2DM induction (P-value:0.029). There was a significant difference between the groups in expressing Glut-4 in the left ventricle. The post hoc test confirmed a significant increase in the expression of Glut-4 in the resistance and HIIT group compared to the control group (P-value:0.017 and P-value:0.05).
Conclusion: However, there was no significant difference in expression of Glut-4 between the two groups of resistance and HIIT. Our findings showed that T2DM patients with cardiovascular disease can improve their problem by performing physical activity.
Zeinab Razavimajd, Hasan Matin Homaee, Mohammad Ali Azarbayjani, Parvin Farzanegi,
Volume 9, Issue 1 (volume 9, number 1,2 2017)
Abstract

Objective: Physical activity and herbal medicine can inhabit apoptosis with two different mechanisms. The aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on heart apoptosis regulatory factors in aged rats with chronic kidney disease.
Materials and Methods: In this experimental research, 42 aged male Wistar rats (48-52 weeks) were selected and divided into 6 groups: control, doxorubicin, doxorubicin-salin, doxorubicin- garlic, doxorubicin - exercise, doxorubicin -garlic-exercise (combined). Chronic kidney disease was induced by a single doxorubicin injection (8.5 mg/kg). Swimming training was programmed 3 days /week, 30 min/day for 8 weeks. Both the doxorubicin garlic and combined groups with garlic extract were administered by garlic gavage at a dose of 2.5 g/kg. The renal Bax and Bcl-2 levels were evaluated by ELIZA method. A one-way analysis of variance was used to data analysis (P-value<0.05).
Results: The results showed that, 8 weeks swimming training, garlic supplementation and the combination of exercise and garlic extract caused significant Bax increase and Bcl-2 and the ratio Bax/Bcl-2decrease in heart tissue of aged rats with chronic kidney disease. 
Conclusion: Based on the results of physical activity and garlic separately induce a protective effect on the heart tissue. But combined interventions did not accelerate the combined effects. Therefore, it is suggested to use them separately.
Hoseyn Fatolahi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Hasan Matin Homaee,
Volume 9, Issue 1 (volume 9, number 1,2 2017)
Abstract

In the absence of insulin, regular physical activity facilitates the glucose entry into the cell via affecting several signaling pathways. Moreover, regular exercise improves the lipid profile and increases the paraoxonase-1 (PON-1) activity. PON-1 interacts with High-density lipoprotein (HDL) and, in the presence of calcium, hydrolyzes free radicals, prevents low-density lipoprotein (LDL) oxidation, maintains homocysteine structure in the blood, and inhibits hemoglobin glycation. These factors explain one of the beneficial effects of regular exercise on prevention of cardiovascular diseases. In addition, there is a positive relationship between decreased PON-1 activity and the occurrence of cardiovascular diseases, renal failure, gastric cancer, dyslipidemia, insulin resistance, and even Alzheimer’s disease. Therefore, this study was conducted to evaluate the effect of physical activity on the PON-1 activity and lipid profile. Regular physical activity increased HDL and PON-1 activity in patients with metabolic syndrome. Since PON-1 binds to HDL and increased HDL probably increases the PON-1 activity as well. This finding suggests that regular exercise decreases the effect of one bout exercise on PON-1 response. In addition, in order to improve metabolic syndromes, it is advised to perform aerobic exercise for 150 minutes per week with an intensity of 40-60% of the heart rate reserve (HRR). The exercises should be preferably performed in 3-5 sessions per week according to the intensity. Based on the disease progression, type of consumed drugs, and certain considerations in each group of patients, aerobic, resistance, and flexibility exercises can be performed by using large muscle groups in a continuous training mode. However, in dyslipidemia, continuous aerobic exercises are preferred.

 
Amene Barjaste Yazdi, Hassan Matin Homaee, Maghsood Peeri,
Volume 9, Issue 4 (volume 9, number 4 2017)
Abstract

Objective: The growing prevalence of diabetes makes this disease a health threatening issue. Regular physical activity is a solution in prevention and treatment of diabetes. Therefore, the aim of the present study was to review the effect of exercise trainings on visceral fat tissue in type 2 diabetes patients, based on the studies performed in Iran.
Materials and Methods: The present study is a review concerning the effects of physical training on visceral fat in diabetic patients. The search was performed on SID (Scientific Information Database), Irandoc and Magiran. After the apraise of the articles, 8 studies carried out between 2005 and 2016 in Iran were included.
Results: A review of the studies indicated that participation in regular physical activities improves blood glucose control. It is effective in secretion and gene expression of adipokines in visceral fat tissues. Moreover, it is able to prevent or delay the onset of type 2 diabetes.
Conclusion: Physical activity has a fundamental role in prevention and control of insulin resistance, pre-diabetic circumstances, type 2 diabetes and its health related complications. Both aerobic and resistance exercises improve the action of insulin and the secretion of adipocytokines of the visceral fat tissue.

 
Hossein Kalhor, Maghsoud Peeri, Hasan Matin Homaee, Mojtaba Izadi,
Volume 10, Issue 1 (volume 10, number 1 2018)
Abstract

Objective: Cardiovascular diseases are the main reason of the death in type 2 diabetic patients. The purpose of this study was to evaluate the effect of 6 weeks of resistance training and HITT (High Intensity Interval Training) on GLP-1 gene expression in type 2 diabetes mellitus.
Materials and Methods: For this study, male Wistar rats of Baqiyatallah University of Medical Sciences in Tehran were used as statistical population. The statistical samples consisted of 32 male Wistar 10 weeks old weighing 220 ± 20 gr and were divided into 4 obese groups (3 diabetic type 2 and 1 healthy groups). Groups were diabetic obstruction, resistance exercises, diabetic obesity and HITT exercises. Independent T-test and one way ANOVA were used to examine the results.
Results: The results showed that the expression of GLP-1R in the left ventricle of diabetic rats was 0.6% lower than that of the non-diabetic group, due to type 2 diabetes induction. There was a significant difference between the groups in expressing GLP-1R in the left ventricle. The post hoc test confirmed a significant increase in the expression of GLP-1R in the resistance and Interval group compared to the control group. However, there was no significant difference in expression of GLP-1R between the two groups.
Conclusion: With regard to the results of this study and other studies that have an effect on the proper administration of Glp-1 and its receptor on the heart, it can be proven to heart patients that they can recover by performing physical activity.

 
Amene Barjaste Yazdi, Hassan Matin Homaee, Maghsood Peeri,
Volume 10, Issue 2 (volume 10, number 2 2018)
Abstract

Objective: Reducing white adipose tissue is an important strategy for treatment of obesity and its related metabolic disorders. The purpose of this study was to determine the effect of endurance exercise and adenosine consumption on the expression of selected genes of thermogenic pathway in the visceral adipose tissue of obese male rats.
Materials and Methods: Twenty male wistar rats were fed on a high-fat diet (40 % fat) 12 weeks to get mean weight 319±30 gr. The rats were selected randomly in four groups; control-saline, control-adenosine, exercise-adenosine and exercise-saline. The adenosine groups received 0.2mgr/kg adenosine 12 weeks (seven days a week), 3 hours before exercise. The exercise schedule included running on the turning wheel without slope, performed 12 weeks, five sessions a week, with the speed of 20-25 meters per minute for 15-31 minutes. About 48 hours after the last exercise session, the rat’s kidneys were removed and frozen immediately. In order to measure the relative expression of UCP-1 gene, the method of Real Time (RT) - PCR based on SYBR-Green dye was used. The gathered data was studied using the statistical method of two-way analysis of variance.
Results: Twelve weeks of endurance exercise with medium intensity and adenosine consumption resulted a significant increase of UCP-1 gene expression (P-value: 0.001 and P-value: 0.005 accordingly). Nevertheless, the collective effect of exercise and adenosine is indicative of insignificant difference in changes of the relative expression of UCP-1 gene in visceral adipose tissue.
Conclusion: Endurance exercise and adenosine consumption independently led to an increase in UCP-1 gene expression in the visceral adipose tissue of obese male rats Nevertheless, the collective effect of exercise and adenosine is indicative of insignificant difference in changes of the relative expression of UCP-1 gene in visceral adipose tissue. It is probable that some mechanisms be activated through the collective effect of exercise and adenosine that reduce the synergic effect of exercise and adenosine.
Ali Fakourian, Homaee Hasan Matin, Mohammad Ali Azarbayjani, Parvin Farzanegi,
Volume 11, Issue 2 (volume 11, number 2 2019)
Abstract

Objective: Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL2 and some mitochondrial enzymes of the kidney in diabetic rats.
Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were simple randomly divided into six groups: 1) placebo group, 2) healthy control group, 3) diabetic control group, 4) diabetic group receiving L- carnitine, 5) diabetic group of aerobic training and 6) diabetic group of aerobic training and recipient of L-carnitine. Rats with a serum glucose level higher than 300 mg/ dL were considered diabetic. L-carnitine recipients received 100 mg of L-carnitine daily orally. The dependent variables of the study were measured 24 hours after the last training program session by ELISA in kidney tissue. Data were analyzed by Shapiro- Wilk and two way ANOVA and Tukey post hoc test at P-value< 0.05.
Results: The results showed that the combined effect of aerobic training and supplementation of L-carnitine on Bcl2 factor of kidney tissue of rats with diabetes has a significant effect (P-value: 0.019). But aerobic exercise (P-value: 0.969) and supplementation of L-carnitine (P-value: 0.584) were not significant.
Conclusion: The results of this study showed that the combined effect of aerobic exercise and supplementation of L-carnitine on CPT2 and Malonyl COa and Bcl2 have a significant effect on the kidney of diabetic rats. Also, exercise alone and consumption of L-carnitine alone do not have a significant effect.
Fariba Bakhtiari, Hasan Matin Homaee, Farshad Ghazalian,
Volume 12, Issue 2 (volume 12, number 2 2020)
Abstract

Objective: The goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (TNF-α), hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats.
Materials and Methods: In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), diabetic aerobic training, diabetic control and healthy control (n=10). Induction of type 2diabetes (T2DM) was done by intraperitoneal infusion of streptozotocin. The progressive aerobic training protocol entailed 4 weeks, 5 sessions per week running on treadmill at velocity of 20 m/min for 60 min. The gene expression of TNF-α, VEGF and HIF-1α were measured by real time & PCR. One way analysis of variance and bonferroni test were applied to analysis the data. The significant level was set at P-value< 0.05.
Results: The results indicated that the aerobic training induced significant decrease in TNF-α mRNA (P-value< 0.001) and significant increase in HIF-1α mRNA (P-value< 0.001) and VEGF mRNA (P-value< 0.001) compared to diabetic control group.
Conclusion: It appears that aerobic training with reduction of TNF-α issues an affirmative effect on angiogenesis, as a result, it improves diabetic cardiac.
Mostafa Farhadi, Hasan Matin Homaee, Parvin Farzanegi Arkhazlou,
Volume 12, Issue 3 (volume 12, number 3 2020)
Abstract

Objective: The beneficial effects of exercise and ginger extract have been reported to improve obesity-related indicators. The aim of this study was to evaluate the effect of aerobic training and ginger extract on lipid profiles, body composition and selected liver enzymes in obese menopausal women.
Materials and Methods: In this semi-experimental trial, 48 obese menopause women (age; 53-58 yr) were randomly divided into 4 groups including control, ginger extract, aerobic training and aerobic training -ginger extract. Aerobic training was performed 3 sessions a week, 60 minutes, with 50-70% maximum heart rate and for 24 weeks. The subjects consumed ginger extract three times a day in 500 mg capsule for 24 weeks. For analyzing the data, two-way ANOVA and Tukey's post hoc test was used with SPSS–23 and the significance level was P-value≤ 0.05.
Results: The results showed that 12 and 24 weeks of training, ginger and ginger - training significantly decreased ALT and AST in obese menopausal women (P-value= 0.001). Also, 12- and 24-weeks’ ginger- training resulted to improve of body composition and lipid profile in obese menopausal women (P-value= 0.001).
Conclusion: According to the findings, regular aerobic training and ginger supplementation have a beneficial effect on body composition and improvement of some liver enzymes and lipid profiles in obese menopausal women. These changes were higher in the Ginger-training group after six months of intervention

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