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Showing 14 results for Peeri

Zohre Amirkhani, Mohammad Ali Azarbayjani, Hasan Matin Homaei, Maghsoud Peeri,
Volume 8, Issue 3 (volume 8, number 3 2016)
Abstract

Objective: Despite the prevalence of obesity related liver disease in many countries, there is still no definitive pathway for prevention and treatment. The aim of this study was to determine the effect of combining resistance training and curcumin supplementation on liver enzyme in inactive obese and overweight Females.
Materials and Methods: The study was done in a quasi-experimental trial. In this regard, thirty-one inactive young females (BMI: 28-32 age: 20-35 years) were divided into one of four homogenized groups: curcumin (CUR; n=9); that consumed 80 mg Nano-micelles curcumin/day for 8 weeks and curcumin plus resistance training (50%-80% of 1RM) (RTCUR; n=9) placebo (PL; n=7), resistance training plus placebo (RTPL; n=7). The resistance training was performed three sessions per week for a total of eight weeks.
Results: The results showed that AST (P-value:0.004) and ALT (P-value:0.005) concentration significantly decreased in RTCUR group. However, findings revealed no significant difference in ALP (P-value:0.2), GGT (P-value: 0/3) levels in RTCUR group following eight weeks of exercise training.
Conclusion: Findings suggested that ALT and AST, waist-hip ratio, and Body Fat% are improved by simultaneous use of resistance training and curcumin supplementation.
Mehran Gahramani, Mohammad Ali Azarbayjani, Maghsod Peeri, Atefeh Raoufi,
Volume 8, Issue 3 (volume 8, number 3 2016)
Abstract

Objective: Physical exercise reduces myocardial apoptosis but its molecular process is unclear yet. The activated Caspase-9 has a key role in advancing the process of apoptosis. The aim of this study was to evaluate the effect of aerobic interval training intensity on the process of apoptosis in the 10-week male obese wistar rats with myocardial infarction.
Materials and Methods: In this clinical trial,18 rats after myocardial infarction induction were divided into three experimental groups of high intensity (Interval running for 60 minutes on a treadmill, each cycle consisting of 4 minutes running with 55-60% of VO2max and 2 minutes’ active recovery with an intensity of 45-50% VO2max, four days a week for 6 weeks) and low intensity (Interval running for 60 minutes on a treadmill, each cycle consisting of 4 minutes running with 85-90% of VO2max and 2 minutes’ active recovery with an intensity of 50-60% VO2max, four days a week for 6 weeks) and a control group (no training). The concentration of cardiomyocytes caspase-9, as the main indicator of apoptosis was measured by qRT-PCR.
Results: The concentration of caspase-9 was higher in the control group than the high intensity training group (P=0.012) and the low intensity training group (P=0.002). The high intensity training group had higher Caspase index values than the low intensity training group (P≥0.001).
Discussion: The findings of this study indicated aerobic interval training resulted in the expression of caspase-9 gene and thus reducing the occurrence of cardiomyocytes apoptosis after myocardial infarction.
Sirous Farsi, Mohammad Ali Azarbayjani, Seyed Ali Hoseini, Maghsoud Peeri,
Volume 8, Issue 3 (volume 8, number 3 2016)
Abstract

Objective: The purpose of this study was to investigate the effects of endurance training accompany with taking genistein on Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and C-reactive protein (CRP) levels in diabetic rats.
Materials and Methods: Sixty-four rats were divided into eight groups (1; healthy &sacrificed  at the first week, 2; healthy &sacrificed  at the last week, 3; diabetic &sacrificed  at the first week, 4; diabetic &sacrificed  at the last week, 5; endurance training, 6; taking genistein, 7; endurance training with taking genistein, and 8; placebo). The training groups were participated in three week sessionsof running on animal treadmill with span of 60 min and intensity range from 17 to 28 (m/s), during eight weeks. In addition, the genistein groups took daily amounts of 30 (mg/kg), through Intraperitoneal injection. In order to analyze data, one-way ANOVA and Toki post-hoc test were implemented (P≤0.05).
Results: The results showed that induction of diabetes would lead to increases in ICAM-1, VACAm-1, and CRP levels, among the rats. Though, all the three of endurance training, taking genistein and endurance training with taking genistein would cause significant reductions in the increased levels of ICAM-1 and CRP (P<0.05). Nevertheless, those mentioned three could not significantly decrease the increased level of VCAM-1, in the statistical aspect (P>0.05). Moreover, there was no significant difference between the effects of the three endurance training, taking genistein, and endurance training with taking genistein (P>0.05).
Conclusion: Eight weeks endurance training and also taking genistein do own improving influences on Inflammatory and cardiovascular risk factors among diabetic rats. Though, their combination does not have any synergistic effect.
Mania Roozbayani, Maghsoud Peeri, Hamid Agha-Alinejad, Mohammad Ali Azarbayjani,
Volume 8, Issue 3 (volume 8, number 3 2016)
Abstract

Objective: High-intensity interval training (HIIT) and continues aerobic training (CT) have cardio-protective effects in diabetic rats. The functional role of microRNA in heart was studied. Only miR-29a levels were found to correlate with cardiac fibrosis, This study tests the hypothesis that applying HIIT and CT cases miR-29a increasing is associated with a reduction of connective tissue growth factor (CTGF)  induced cardiac fibrosis.
Materials and Methods: In this randomized controlled trial, 18 male diabetic rats were included. They were divided into 3 groups called as HIIT, CT and control. Exercise protocol was performed 5 days/week for 5 weeks. The miR-29a and CTGF synthesis were compared between the groups by real time- PCR.
Results: Our results demonstrated that elevation of miR-29a using HIIT (2.67 , P=0.010,) or CT (1.79 , P=0.002) are effective in inhibiting CTGF (HIIT:0.17 P=0.000-CT:0.39 -induced cardiac fibrosis, suggesting that these types training would be selected as a new adjunctive therapy in the heart fibrosis- derived diabetic.
Discussion: The HIIT and CT showed increased levels of miR-29a compared CT group which is shown to decrease CTGF level resulting into lowered fibrosis of heart tissue in diabetic patients.

 
Mania Roozbayani, Maghsoud Peeri, Hamid Agha-Alinejad, Mohammad Ali Azarbayjani,
Volume 8, Issue 4 (volume 8, number 4 2016)
Abstract

Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats.
Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups.
Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027).
Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.

 
Hossein Kalhor, Maghsoud Peeri, Hasan Matin Homaee, Mojtaba Izadi,
Volume 9, Issue 1 (volume 9, number 1,2 2017)
Abstract

Objective: GLUT4 glucose transporter content and glucose transport capacity are closely correlated in muscle. The purpose of current study was to evaluate the effect of 6 weeks of resistance training and High-Intensity Interval Training (HITT) on Glut-4 gene expression in type 2 diabetes mellitus (T2DM) by high fat diet and STZ.
Materials and Methods: This study was done on 32 male Wistar in Baqiyatallah University of Medical Sciences-Tehran. The study sample consisted of 32 male Wistar 10 week old weighting 220 ± 20 gr which were divided into 4 obese groups. One diabetic group had to do resistance training and another group did HIIT. One more diabetic group and the healthy group did not do any activities. At the end, the amount of their left ventricular GLUT-4 was measured. Independent t-test and one way ANOVA were used to examine the results.
Results: The expression of Glut-4 in the left ventricle of diabetic rats was 0.72 lower than that of the non-diabetic group, due to T2DM induction (P-value:0.029). There was a significant difference between the groups in expressing Glut-4 in the left ventricle. The post hoc test confirmed a significant increase in the expression of Glut-4 in the resistance and HIIT group compared to the control group (P-value:0.017 and P-value:0.05).
Conclusion: However, there was no significant difference in expression of Glut-4 between the two groups of resistance and HIIT. Our findings showed that T2DM patients with cardiovascular disease can improve their problem by performing physical activity.
Hoseyn Fatolahi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Hasan Matin Homaee,
Volume 9, Issue 1 (volume 9, number 1,2 2017)
Abstract

In the absence of insulin, regular physical activity facilitates the glucose entry into the cell via affecting several signaling pathways. Moreover, regular exercise improves the lipid profile and increases the paraoxonase-1 (PON-1) activity. PON-1 interacts with High-density lipoprotein (HDL) and, in the presence of calcium, hydrolyzes free radicals, prevents low-density lipoprotein (LDL) oxidation, maintains homocysteine structure in the blood, and inhibits hemoglobin glycation. These factors explain one of the beneficial effects of regular exercise on prevention of cardiovascular diseases. In addition, there is a positive relationship between decreased PON-1 activity and the occurrence of cardiovascular diseases, renal failure, gastric cancer, dyslipidemia, insulin resistance, and even Alzheimer’s disease. Therefore, this study was conducted to evaluate the effect of physical activity on the PON-1 activity and lipid profile. Regular physical activity increased HDL and PON-1 activity in patients with metabolic syndrome. Since PON-1 binds to HDL and increased HDL probably increases the PON-1 activity as well. This finding suggests that regular exercise decreases the effect of one bout exercise on PON-1 response. In addition, in order to improve metabolic syndromes, it is advised to perform aerobic exercise for 150 minutes per week with an intensity of 40-60% of the heart rate reserve (HRR). The exercises should be preferably performed in 3-5 sessions per week according to the intensity. Based on the disease progression, type of consumed drugs, and certain considerations in each group of patients, aerobic, resistance, and flexibility exercises can be performed by using large muscle groups in a continuous training mode. However, in dyslipidemia, continuous aerobic exercises are preferred.

 
Amene Barjaste Yazdi, Hassan Matin Homaee, Maghsood Peeri,
Volume 9, Issue 4 (volume 9, number 4 2017)
Abstract

Objective: The growing prevalence of diabetes makes this disease a health threatening issue. Regular physical activity is a solution in prevention and treatment of diabetes. Therefore, the aim of the present study was to review the effect of exercise trainings on visceral fat tissue in type 2 diabetes patients, based on the studies performed in Iran.
Materials and Methods: The present study is a review concerning the effects of physical training on visceral fat in diabetic patients. The search was performed on SID (Scientific Information Database), Irandoc and Magiran. After the apraise of the articles, 8 studies carried out between 2005 and 2016 in Iran were included.
Results: A review of the studies indicated that participation in regular physical activities improves blood glucose control. It is effective in secretion and gene expression of adipokines in visceral fat tissues. Moreover, it is able to prevent or delay the onset of type 2 diabetes.
Conclusion: Physical activity has a fundamental role in prevention and control of insulin resistance, pre-diabetic circumstances, type 2 diabetes and its health related complications. Both aerobic and resistance exercises improve the action of insulin and the secretion of adipocytokines of the visceral fat tissue.

 
Hossein Kalhor, Maghsoud Peeri, Hasan Matin Homaee, Mojtaba Izadi,
Volume 10, Issue 1 (volume 10, number 1 2018)
Abstract

Objective: Cardiovascular diseases are the main reason of the death in type 2 diabetic patients. The purpose of this study was to evaluate the effect of 6 weeks of resistance training and HITT (High Intensity Interval Training) on GLP-1 gene expression in type 2 diabetes mellitus.
Materials and Methods: For this study, male Wistar rats of Baqiyatallah University of Medical Sciences in Tehran were used as statistical population. The statistical samples consisted of 32 male Wistar 10 weeks old weighing 220 ± 20 gr and were divided into 4 obese groups (3 diabetic type 2 and 1 healthy groups). Groups were diabetic obstruction, resistance exercises, diabetic obesity and HITT exercises. Independent T-test and one way ANOVA were used to examine the results.
Results: The results showed that the expression of GLP-1R in the left ventricle of diabetic rats was 0.6% lower than that of the non-diabetic group, due to type 2 diabetes induction. There was a significant difference between the groups in expressing GLP-1R in the left ventricle. The post hoc test confirmed a significant increase in the expression of GLP-1R in the resistance and Interval group compared to the control group. However, there was no significant difference in expression of GLP-1R between the two groups.
Conclusion: With regard to the results of this study and other studies that have an effect on the proper administration of Glp-1 and its receptor on the heart, it can be proven to heart patients that they can recover by performing physical activity.

 
Amene Barjaste Yazdi, Hassan Matin Homaee, Maghsood Peeri,
Volume 10, Issue 2 (volume 10, number 2 2018)
Abstract

Objective: Reducing white adipose tissue is an important strategy for treatment of obesity and its related metabolic disorders. The purpose of this study was to determine the effect of endurance exercise and adenosine consumption on the expression of selected genes of thermogenic pathway in the visceral adipose tissue of obese male rats.
Materials and Methods: Twenty male wistar rats were fed on a high-fat diet (40 % fat) 12 weeks to get mean weight 319±30 gr. The rats were selected randomly in four groups; control-saline, control-adenosine, exercise-adenosine and exercise-saline. The adenosine groups received 0.2mgr/kg adenosine 12 weeks (seven days a week), 3 hours before exercise. The exercise schedule included running on the turning wheel without slope, performed 12 weeks, five sessions a week, with the speed of 20-25 meters per minute for 15-31 minutes. About 48 hours after the last exercise session, the rat’s kidneys were removed and frozen immediately. In order to measure the relative expression of UCP-1 gene, the method of Real Time (RT) - PCR based on SYBR-Green dye was used. The gathered data was studied using the statistical method of two-way analysis of variance.
Results: Twelve weeks of endurance exercise with medium intensity and adenosine consumption resulted a significant increase of UCP-1 gene expression (P-value: 0.001 and P-value: 0.005 accordingly). Nevertheless, the collective effect of exercise and adenosine is indicative of insignificant difference in changes of the relative expression of UCP-1 gene in visceral adipose tissue.
Conclusion: Endurance exercise and adenosine consumption independently led to an increase in UCP-1 gene expression in the visceral adipose tissue of obese male rats Nevertheless, the collective effect of exercise and adenosine is indicative of insignificant difference in changes of the relative expression of UCP-1 gene in visceral adipose tissue. It is probable that some mechanisms be activated through the collective effect of exercise and adenosine that reduce the synergic effect of exercise and adenosine.
Javad Ramezani, , Mohammad Ali Azarbayjani, Maghsoud Peeri,
Volume 11, Issue 4 (volume 11, number4 2019)
Abstract

Objective: Aerobic training and berberine chloride include antioxidant characteristics. In this study, aerobic training and berberine chloride intervention on the activity of antioxidant enzymes and lipid peroxidation of pancreatic tissue were investigated in type 1 diabetic male wistar rats.
Materials and Methods: In the current study, 56 Wistar male rats were randomly assigned to seven different groups (n= 8), these groups include healthy control, diabetic control, Berberine-treated diabetes (15&30 mg/kg), aerobic training-treated diabetes, Diabetes treated with Berberine and aerobic training (15&30 mg/kg). The aerobic training schedule consisted of 6 weeks treadmills with a frequency of 5 sessions per week. The Berberine was also fed a specific dose every day and a half before training. The superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were assessed using ELISA method.
Results: The results showed that aerobic training, as well as the intervention of Aerobic Training and Berberine chloride, had a significant effect on the increase of antioxidant enzymes SOD and CAT in the pancreatic tissue groups (P-value< 0.05), but did not significantly affect the GPX level (P-value> 0.05). There was a significant decrease in MDA level in all treatment groups (P-value< 0.05). In diabetic groups that received both treatments at the same time, the MDA level more decreased (P-value< 0.0005).
Conclusion: The aerobic training and berberine chloride concurrent intervention have a greater effect on the antioxidant enzymes in the pancreatic tissue of diabetic specimens. Therefore, it is recommended that aerobic training be done with berberine chloride.
Milad Rahimi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Parvin Farzanegi,
Volume 12, Issue 1 (volume 12, number 1 2020)
Abstract

Objective: Physical exercise has different effects on oxidative stress. Oxidative stress influences TLR4 and NFkB gene expression. The purpose of this study was to investigate the effect of aerobic training and vitamin D on gene expression of TLR4 and NFkB in lung tissue of obese rats exposed to oxygenated water.
Materials and Methods: In an experimental study, 30 obese male wistar rats were randomly divided into five groups: control, oxygenated water, oxygenated water + vitamin D, oxygenated water + aerobic training, and oxygenated water + aerobic training + vitamin D. All the rats were injected intraperitoneally with oxygenated water. Vitamin D was performed by intraperitoneal injection of 0.5 μg daily for eight weeks. The aerobic training protocol included 8 weeks, 5 sessions per week running on treadmill. TLR4 and NFkB gene expression of lung tissue were investigated using real time & PCR. Two-way ANOVA and Bonferroni post hoc test were used to analysis the data. The significant level was set at P-value< 0.05.
Results: Aerobic training significantly reduced TLR4 expression compared with other groups (P-value: 0.046) but did not significantly affect the expression of NFkB gene (P-value: 0.261). Vitamin D alone and aerobic training and vitamin D interaction did not significantly alter the gene expression of TLR4 (P-value: 0.072 and P-value: 0.695, respectively) and NFkB (P-value: 0.243 and P-value:< 0.195, respectively).
Conclusion: It seems that performing aerobic training is likely to be beneficial in reducing oxidative stress and inflammation compared to inactivity.
Farzaneh Soltanipour Jounaghani, Maghsoud Peeri, Mohammad-Ali Azarbayjani,
Volume 12, Issue 1 (volume 12, number 1 2020)
Abstract

Objective: The aim of this study was to investigate the effect of 6 weeks of detraining after 12 weeks of high intensity interval training (HIIT) on the expression of AKT1 and mTORc1 genes in the left ventricle of wistar diabetic rats.
Materials and Methods: Twenty-eight wistar male rats were selected as the study sample and were divided in four groups of healthy control, diabetic control, diabetic HIIT and diabetic HIIT + detraining. The HIIT period was 12 weeks and the detraining period was 6 weeks. Each session consisted of 30 minutes, which included running on a treadmill with one-minute repetitions and a two-minute active recovery between them. To measure AKT1 mRNA and mTORc1 mRNA by RT-Real time PCR, a single-step single step SYBR TAKARA kits from Takara Company was used according to the company's instruction.
Results: HIIT caused a significant increase in AKT1 gene expression (P-value= 0.001). AKT1 decreased with detraining that was not significant (P-value= 0.34) but it was still significantly higher than before training (P-value= 0.017). HIIT caused a significant increase in mTORc1 gene expression (P-value= 0.001) and although it decreased with detraining (P-value= 0.15) and it was no significantly higher than before training (P-value= 0.19).
Conclusion: HIIT led to increased expression of AKT1 and mTORc1 genes in type 2 diabetic rats, while also producing favorable changes in the cardiac structure of these rats. Also, 6 weeks of detraining did somewhat reduce these favorable changes.
Hossein Heidari, Mohammad Ali Azarbayjani, Maghsoud Peeri, Parvin Farzanegi, Seyed Ali Hosseini,
Volume 12, Issue 4 (volume 12, number 4 2020)
Abstract

Objective: Exercise and herbal medicine Berberine are known as anti-inflammatory agents. This study aimed to evaluate the effect of 4-weeks of endurance training and Berberine Chloride (BC) consumption on inflammatory factors and glycemic index in male wistar diabetic rats.
Materials and Methods: In an experimental trial, 36 male wistar rats divided into 6 groups of 6 rats including 1) control, 2) 15 mg/kg BC, 3) 30 mg/kg BC, 4) endurance training, 5) endurance training with 15 mg/kg BC and 6) endurance training with 30 mg/kg of BC. During 4 weeks, rats in groups 2, 3, 5, and 6 received BC by gavage at specified doses, and rats in groups 4- 6 also ran on the treadmill at speeds of 10-15 m/min for 10-30 minutes. For statistical analysis of data-independent sample T-test, two-way ANOVA were used (P-value= 0.05).
Results: Training and BC significantly increased function of pancreatic beta cells and reduced FBS, TNF-α, and IL- 6 (P-value= 0.001); Training significantly increased VO2max and insulin; interaction of training and BC on an increase of VO2max and reduction of TNF-α were significant (P-value= 0.001) and 30 mg/kg BC reduced TNF-α and FBS much more than 15 mg/kg BC (P-value= 0.001).
Conclusion: It appears that Endurance training and BC can decrease glycemic index and inflammatory markers of diabetes and the effects of BC is dose-dependent, so that the 30 mg/kg BC is more effective rather than the 15 mg/kg BC.

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