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Showing 16 results for Razavi

Zahra Razavi, Ali Amanati,
Volume 3, Issue 1 (4-2011)
Abstract

OBJECTIVES: To evaluate the effect of two simultaneous protocols in reducing recovery time and assessment of adverse effects of different fluid replacement therapy in management of diabetic ketoacidosis. MATERIALS AND METHODS: In this randomized clinical trial study, two standard protocols were chosen to evaluate recovery time and incidence of DKA complications. RESULTS: 18 subjects who had severe diabetic ketoacidosis were included in our analysis. In the course of treatment, hypokalemia happened in 5 cases in protocol 1 and 4 cases in protocol 2. Hypernatremia occurred in 2 cases of protocol 1 and 4 cases in protocol 2. Hyponatremia occured in 4 cases of protocol 1 and 2 cases in protocol 2. The mean recovery time of acidosis in protocol 1 was 21 ± 5.9 (mean ± SD) hours and 23 ± 10.9 hours in protocol 2. None of them had any signs and symptoms of cerebral edema or mental status deterioration in the course of treatment. CONCLUSION: According to our study, different volume deficit calculated as a base for dehydration which was replaced in different times and in a similar clinical setting, had not added any risk of complications during the treatment. Also no significant differences were found in recovery time related to the different fluid replacement protocols. We also found that complication of therapy increases with the severity of diabetic ketoacidosis.
Zahra Razavi, Fariba Mohammadi,
Volume 4, Issue 2 (6-2012)
Abstract

Objective: Limited joint mobility (LJM) has been described as the earliest clinical complication of diabetes mellitus. This study was performed to determine the frequency of limited joint mobility and to evaluate the association between LMJ and some chronic diabetic complications. Materials and Methods: A total of 125 patients with type 1 diabetes mellitus aged 11.89 ±3.75 years, with 4.2±2 years mean duration of disease were studied. Diabetic patients were compared with 125 healthy young controls that were group-matched for age and sex. Variables such as age, sex, duration of disease and mean HbA1c level were obtained from the patients′ medical records. LJM was assessed by observing the small joints of the hands in the prayer position. Student t-test and chi-square (X2) were used for comparisons between groups. Results: The frequency of LJM was significantly higher in diabetic patients compared to healthy controls (19.2% vs. 4%, p=0.001). Diabetic patients with LJM had not longer duration of diabetes than those without LJM (4.33 years compared to 4.08 years, p=0.55). Its presence was significantly related to microalbuminuria (p=0.017) and higher systolic blood pressure (p=0.001). Conclusion: Diabetic patients showed a significantly higher frequency of LJM than non-diabetic patients. LJM in the hands of patients with type 1 DM was associated with microalbuminuria but it was not related to retinopathy.
Vahid Dolat-Abadi Farahani, Seid Kazem Razavi-Ratki, Nasim Namiranian, Mahmood Emami-Meybodi, Hossein Nough, Hossein Razavi, Naser Hossein Sartipzadeh,
Volume 5, Issue 3 (volume 5, number 3 2013)
Abstract

Abstract Objective: Abnormal values of the transient ischemic dilation (TID) ratio are associated with severe and extensive coronary artery disease (CAD). TID can be used as a diagnostic and prognostic marker of CAD in diabetic patients. The aim of current study was to determine the pooled estimate of TID ratio in single myocardial perfusion scan in diabetic patients by a systematic review and meta-analysis. Materials and Methods: The electronic databases of PubMed/MEDLINE, Scopus (EMBASE), Web of Science, and Cochrane Library up to December 30, 2013 were searched. The reference lists of all included studies were searched for further studies. The search strategy was according to PICO characteristics. The heterogeneity between the studies was accounted with P<0.1. The random/fixed effect model was used according to the heterogeneity. Point estimates were pooled estimate of TID ratio with 95% confidence interval (CI) by pooling available data. Egger’s test was used to assess publication bias. Results: The primary search contained 423 studies. Totally, 17 studies met the inclusion criteria and the critical appraisal scores. The TID ratio in four single pharmacological stress studies with angiographic evidence of low risk or normal coronary artery disease was 1.079 (95% CI: 1.07-1.089). Conclusion: Our findings were achieved according to the purpose of the study and the pooled estimate of TID±SD was calculated. The pooled estimate of TID was so smaller than the TID calculated in individual studies and so precise.
Reza Nafisi-Moghadam, Nasim Namiaranian, Maryam Karbasi, Hashem Hojat, Sied Kazem Razavi Ratki,
Volume 7, Issue 2 (volume 7, number2 2015)
Abstract

Objective: Gestational diabetes mellitus occurs during pregnancy is associated with increased cardiovascular risk. Carotid intima media thickness (CIMT) is a surrogate maker of subclinical atherosclerosis. The aim of this study is assessment of relationship between CIMT and infra-renal abdominal aorta diameter in women with and without Gestational Diabetes Mellitus.

Materials and Methods: The current case-control study was conducted in department of radiology of Shahid Sadoghi hospital in Yazd medical science university 2012 to 2013. Forty women between 20-40 years old with at least 6 months after pregnancy were enrolled, 20 participants with GDM in last pregnancy and 20 participants without history of GDM. All participants underwent physical exam and laboratory findings. Finally Carotid intima-media thickness and infra abdominal aorta diameter were obtained.

Results: over all comparison between GDM and non GDM groups revealed no significant difference in mean CIMT and infra-renal abdominal aorta diameter. FBS between two groups reveal significant statistically difference (P-value<0.05). Also Pearson correlation analysis shows association between infera-renal abdominal aorta diameter and cholesterol and LDL in non GDM participate.

Conclusion: Our study suggested GDM may not relate to CIMT and infera-renal abdominal aorta diameter. Also current study revealed women with history of GDM are prone to having impaired fasting glucose.


Sied Kazem Razavi Ratki, Amirpasha Amelshahbaz, Reza Nafisi-Moghadam, Naser Hossein Sartipzadeh,
Volume 7, Issue 2 (volume 7, number2 2015)
Abstract

Cardiovascular disease (CAD) screening in asymptomatic patients with diabetes mellitus is controversial. An exercise stress test is a safe and effective initial testing for Ischemic Heart Disease (IHD) screening. Treadmill stress test is not the best screening method for a particular patient who is not able to exercise, abnormal electrocardiogram (ECG) or positive exercise treadmill test (ETT) and other anatomical or functional studies are recommended to evaluate for the myocardial ischemia. This concept is supported by the high rate prevalence of silent myocardial ischemia, CAD and cardiovascular events rate. Coronary angiography is an expensive and invasive test which is considered as gold standard for diagnosis obstructive CAD and not be used for screening. In this review article we discussed about anatomical modalities (Coronary Artery Calcium Score (CACS)) and nuclear imaging (SPECT) for evaluation of silent ischemia.


Arezoo Aghakoochaki, Seyed Kazem Razavi Ratki , Seyed Ali Sadr Bafghi, Seyed Mohamad Hossein Sadr-Bafghi, Alireza Mardanshahi, Reza Nafisi Moghadam, Nasim Namiranian,
Volume 7, Issue 3 (volume 7, number3 2015)
Abstract

Objective: Social determinant of health (SDH) are different from medical care and services. These factors themselves are affected by social policies, and they influence health more than medical care and services do. Due to the importance of chronic non-communicable diseases especially diabetes in Yazd, and assuming the effect of SDH, the present study was conducted in order to examine the relationship between diabetes control and SDH.

Materials and Methods: This was a cross-sectional study. The statistical population were diabetic patients who has referred to diabetes center of Yazd. Sampling method was systematic random selection. The study inclusion criteria was type II diabetes, and exclusion criteria were gestational diabetes, type I diabetes, lack of inclination to participate in the study, lack of access to the patient, death, and immigration from Yazd. In order to examine the SDH more precisely, a combined variable labeled “socioeconomic position (SEP)” including the patient’s place of residence and job was created.

Results: Totally 511 type II diabetes patients were studied; 288 women (56.4%) and 223 men (43.6%). The mean age of participants was 56.68 years with a standard deviation (SD) of 10.566. Among patients 119 patients (23.3%) reported tobacco consumption. (Table 1) Out of the sample, 223 men whose mean (±SD) HbA1c was 8.6284±1.87 and 288 women whose mean (±SD) HbA1c was 8.6269±1.69 were reported to have no significant difference in terms of their gender and hemoglobin number (P-value=0.922). There were significant difference in HbA1c mean between different groups and SEP.

Conclusion: It can be concluded that the role of social factors and also psychological and mental criteria in understanding the risk of chronic disease and health is due to the negative effects of economic and collective factors, and that the highest level of physical and mental risks is among patients who have experienced hard conditions over time.


Seid Kazem Razavi Ratki, Seyed Ali Sadr Bafghi, Seid Hossein Razavi, Seyed Mohamad Hossein Sadr Bafghi, Alireza Mardanshahi, Nasim Namiranian, Naser Hossein Sartipzadeh, Mohamad Ali Jelodari, Reza Nafisi Moghadam, Hassan Haghaninejad,
Volume 7, Issue 4 (volume 7, number4 2015)
Abstract

Objective: The risk of cardiac death in diabetic patients is 3 times more than non-diabetics. But it is not determined who need cardiac screening. About 41% of diabetic patients with silent ischemia are missed. the carotid intima-media thickness (CIMT) and ankel brachial index are two independent,simple and non invasive method in vascular complications diagnosis in diabetic patients.The aim of this study was to evaluate the assosiation of CIMT and ABI in prediction of silent myocardial ischemia in myocardial perfusion scintigraphy in Asymtomatic diabetic papulation.

Materials and Methods: This was an analytic cross-sectional study. The convenient sampling was used. About 114 patients with diabetics and no history and symptom of coronary artery disease (CAD) were included. Myocardial perfusion scan (MPI), CIMT and ABI were done. All of statistical analysis was done by SPSS-20.

Results: Totally114 diabetic patients without cronary artery disease symptoms were included .About 66.7% were female. The mean age of patients was 53.8± 8.6 years old. About 50% (57) of patients were normal. The mean of CIMT was 0.93 ± 0.21 and mean ABI was 0.97 ± 0.11. Regarding the anlysis of variance (ANOVA) there were significant differences of mean CIMT and ABI between normal and moderate to severe ischemia in MPI.

Conclusion: Our findings showed that CIMT and ABI is significantly different between patients with and without ischemia. The CIMT and ABI are simple, non-invasive, and inexpensive tests that may be used to identify individuals who are at high risk of developing cardiovascular disease (diabetic patients).


Seid Kazem Razavi Ratki, Mojgan Kord, Seyed Ali Sadr Bafghi, Nasim Namiranian, Mohamad Sobhan Ardekani, Nader Nouri-Majalan, Reza Nafisi Moghadam,
Volume 7, Issue 4 (volume 7, number4 2015)
Abstract

Objective: Atherosclerosis disease, inflammation and malnutrition have strong association with end stage renal disease (ESRD). Diabetes mellitus (DM) is the most commonly ESRD causes. Diabetic nephropathy (DN) could be associated with inflammation. Type 2 diabetic patients with advanced nephropathy show the highest levels of inflammatory markers. This study was designed to determine the association between malnutrition–inflammation–atherosclerosis (MIA complex) in Diabetic patients with peritoneal dialysis.

Materials and Methods: Fifty seven diabetic patients on peritoneal dialysis were investigated and demographic variables (age, gender, BMI and dialysis duration), Inflammatory markers (cholesterol, Albumin and CRP) were measured in routine protocol. CIMT (Carotid Intima-Media Thickness) and plaque number were evaluated by B-Mode ultrasonography (7.5 -10 MHZ probe) in supine position.

Results: the mean age (Standard deviation) of patients was 51±17.3 years. The mean time on dialysis was 26.12 ±25.42 (range 4–120) months. The mean of IMT was 5.98±1.17 mm and mean of plaques were 1.80±2.01. Results of Analysis of variance (ANOVA) showed that older patients have more carotid plaques (P-Value= 0.000). There was a significant relation between serum albumin and number of plaques (P-Value=0.043). CIMT and number of plaque revealed significant correlation with age, serum albumin and dialysis duration (P<0.05).

Conclusion: Our findings showed, in diabetic patients on peritoneal dialysis, carotid atherosclerosis (CIMT and Number of plaque) is associated with some inflammation, malnutrition markers.


Seid Kazem Razavi Ratki, Mona Kharaji, Nasim Namiranian, Mohammad Sobhan Ardekani, Mahmood Emami, Amirpasha Amlelshahbaz, Karim Sharifi, Reza Nafisi Moghadam,
Volume 8, Issue 2 (volume 8, number 2 2016)
Abstract

Objective: Duplex ultrasonography is a non-invasive, non-expensive screening test for carotid disease. Intima media thickness (IMT) is appropriate for atherosclerosis process diagnosis. Leukoaraisis (LA) increase the risk of cerebrovascular accident (CVA). LA patients need preventive medication for CVA. IMT is a non-invasive diagnostic and prognostic test in LA. The aim of this study was evaluate the carotid IMT and LA in diabetic patients as atherosclerosis surrogate marker.

Materials and Methods: The case-control study was done on 100 diabetic patients and 100 controls. They were selected by simple sampling method in Shaheed Sadoughi MRI unit. Two groups member were matched by age and sex. The patient’s information (age, sex, weight, height, past medical history, smoking history, ischemic heart disease(IHD), CVA and past medication) according the study checklist was collected. All statistical analysis was done by SPSS21.

Results Totally 200 patients were studied, 102 in normal group and 98 in diabetic group. The mean age of patients was 64.39 (±9.12) and 47% participants were male. There were no statistical differences between hypertension and hyperlipidemia frequency in two groups (P-value>0.05). The mean of left CIMT was 0.856 (±0.202) in normal and 0.962 (±171) in diabetics groups (P-value: 0.026). The mean of right CIMT was 0.853 (±0.215) in normal and 0.973 (±188) in diabetics groups (P-value: 0.024). The LA was significantly more prevalent in diabetic patients (P-value:0.001).

Conclusion: LA increases the risk of CVA and dementia. The LA pathology is unknown. The epidemiological studies revealed the age, diabetes, smoking and atherosclerosis are related with LA. Our findings showed that CIMT as an atherosclerosis marker was higher in LA patients than control group.


Reyhane Azizi, Simin Manoochehry, Seyd Kazem Razavi-Ratki, Seyed Mostafa Seyed Hosseini, Mahmoud Vakili, Nasim Namiranian,
Volume 8, Issue 4 (volume 8, number 4 2016)
Abstract

Objective: Blood group as a genetic trail can be associated with type 2 diabetes. The aim of this research was to determine the distribution of ABO frequency and RH blood groups in type 2 diabetic patients referred to Yazd diabetes center.
Materials and Methods: In this research 1502 type 2 diabetes patients of Yazd diabetes center were selected and checked for blood group ,age, sex, duration of diabetes, nephropathy, retinopathy ,diabetes control and familial history of diabetes. Data were analyzed on SPSS-21.
Results: From 1502 patients participated in this study 995 were male (66.2%) and 507 female (33.8%). The mean age (standard deviation) of patients was 52±10.46. About 541 participants (36%) had O blood group, 431 (28%) A, 379 (25%) B, and 150 (10%) AB. About 90.8% patients were RH. The most frequency was observed in blood group O+ (30.9%) and the patients with blood group of AB- had the lowest frequency (0.5%) among patients. The various blood groups were not different in following subgroups; Familial History (P=0.6), diabetes duration (P=0.32), retinopathy (P=0.64), nephropathy (P=0.69), and hypertension (P=0.33). But HbA1c<7 and blood groups were significantly different (P=0.03).
Discussion: The blood group O+ was the most frequent and AB- was the  least frequent among blood groups in this study .But for evaluation of  relationship between blood group and diabetes the prospective studies are suggested.

 
Zeinab Razavimajd, Hasan Matin Homaee, Mohammad Ali Azarbayjani, Parvin Farzanegi,
Volume 9, Issue 1 (volume 9, number 1,2 2017)
Abstract

Objective: Physical activity and herbal medicine can inhabit apoptosis with two different mechanisms. The aim of this study was to assess the combined effect of regular aerobic exercise with garlic extract on heart apoptosis regulatory factors in aged rats with chronic kidney disease.
Materials and Methods: In this experimental research, 42 aged male Wistar rats (48-52 weeks) were selected and divided into 6 groups: control, doxorubicin, doxorubicin-salin, doxorubicin- garlic, doxorubicin - exercise, doxorubicin -garlic-exercise (combined). Chronic kidney disease was induced by a single doxorubicin injection (8.5 mg/kg). Swimming training was programmed 3 days /week, 30 min/day for 8 weeks. Both the doxorubicin garlic and combined groups with garlic extract were administered by garlic gavage at a dose of 2.5 g/kg. The renal Bax and Bcl-2 levels were evaluated by ELIZA method. A one-way analysis of variance was used to data analysis (P-value<0.05).
Results: The results showed that, 8 weeks swimming training, garlic supplementation and the combination of exercise and garlic extract caused significant Bax increase and Bcl-2 and the ratio Bax/Bcl-2decrease in heart tissue of aged rats with chronic kidney disease. 
Conclusion: Based on the results of physical activity and garlic separately induce a protective effect on the heart tissue. But combined interventions did not accelerate the combined effects. Therefore, it is suggested to use them separately.
Seid Kazem Razavi Ratki, Nasim Namiranian, Maryam Alvandi,
Volume 9, Issue 3 (volume 9, number 3 2017)
Abstract

Objective: Diabetes mellitus is an important cause of heart failure deployment of left ventricular mechanical dyssynchrony. Nuclear cardiology phase analysis is an accurate, repeatable and reproducible modality for measurement LV dyssynchrony .The aim of study was assessment of phase analysis parameter including Standard deviation (SD) and band width (BW) in diabetic patient with normal MPI comparing with low risk population for CHD.
Materials and Methods: An analytical cross-sectional study was performed in clinical research development unit of Farshchian heart center, Hamedan University of Medical Sciences. We evaluated 165 patients who underwent SPECT MPI. Study population were 90 diabetic patients with normal MPI (sss<3) and 75 health individuals without diabetes. Phase analysis parameters were compared in both groups using Quantitative Gated SPECT (QGS) software. Independent sample t-test and Pearson correlation test were used to compare the results.
Results: The study results revealed no statistically significant differences in standard deviation (SD) and histogram band width (BW) of the phase analysis between diabetic patients and control group. Furthermore, in diabetic patient LVEF have a negative significant correlation to BW (r=-0.510) and SD (r=-0.422) but in control group there was no significant Pearson correlation is noticed.
Conclusion: Between diabetic patients and low likelihood person for CHD with normal MPI phase analysis parameter (BW and SD) shows no significant difference.

 
Seid Kazem Razavi Ratki, Mahshid Forooghnia, Seyed Mohammad Jalil Abrisham, Reza Nafisi Moghadam,
Volume 9, Issue 3 (volume 9, number 3 2017)
Abstract

Orthosis and prosthesis is an expert knowledge in medical field including the design, fabrication and utilizing of orthosis and prosthesis. An orthosis is a device made of different types of material (plastic, aluminum, foam, leather, etc.) used externally on body segments to modify the structural or functional characteristics of musculoskeletal system to objectives such as: reducing pain, restriction or movements and redistribution of abnormal weight bearing pattern. Poor shoes fitting or abnormal friction may not be considered due to loss of senses in neuropathic diabetic patient. Untreating micro injuries may lead to ulceration and possibly even partial foot amputation. Deformities such as b:union:s, hammer toes, Charcot joint and also muscle weakness reported as secondary complications of neuropathy. It is suggested that in sub-acute stages of neuropathy with complication such as: Charcot joint, insensitive feet or muscles, orthotic prescription can be useful. The aim of this review was to assess the usefulness of therapeutic diabetic footwear (shoes) and insoles in treating diabetic foot.

 
Marzieh Aboutorabi-Zarchi, Saeedeh Jam Ashkezari, Somaye Gholami, Seid Kazem Razavi-Ratki, Nasim Namiranian,
Volume 11, Issue 1 (volume 11, number 1 2019)
Abstract

Objective: The relative stroke risk is increased in patients with diabetes. Awareness and knowledge of the risk factors and symptoms of stroke are essential for prevention and immediate effective treatment of stroke. The aim of the study was to determine baseline knowledge about the warning symptoms and risk factors of stroke in patients with type 2 diabetes (T2DM).
Materials and Methods: This analytical cross-sectional study was conducted in Yazd-Iran 2015-2016. The pilot section included 10 T2DM patients. The main data was collected from 281 patients. The self-conducted checklist about knowledge of stroke risk factors, warning signs as defined by national institute of neurological disorder and stroke was prepared in three following parts. 1) Socio-demographic information. 2) Open-ended question about stroke risk factors, warning sign & symptoms and first action information. 3) Multiple choice questions related to the stroke risk factors, warning sign & symptoms and first action information.
Results: 408 T2DM patients were invited and 281 patients fulfilled in study. Most of them (70.4%) were women. The mean age of patients was 54.09±12.54 years. The most common general risk factors of stroke listed were “high blood pressure (92.9%), unhealthy diet” (86.8%), and “stress” (82.2%).The most common sources of stroke information were friends and family members (73.7%).
Conclusion: Education program to increase T2DM knowledge of stroke may contribute to reducing the risk of stroke and increasing the speed of hospital presentation after the onset of stroke.

 
Marzieh Aboutorabi-Zarchi, Saeedeh Jam Ashkezari, Somaye Gholami, Seid Kazem Razavi-Ratki, Nasim Namiranian,
Volume 11, Issue 1 (volume 11, number 1 2019)
Abstract

Objective: The relative stroke risk is increased in patients with diabetes. Awareness and knowledge of the risk factors and symptoms of stroke are essential for prevention and immediate effective treatment of stroke. The aim of the study was to determine baseline knowledge about the warning symptoms and risk factors of stroke in patients with type 2 diabetes (T2DM).
Materials and Methods: This analytical cross-sectional study was conducted in Yazd-Iran 2015-2016. The pilot section included 10 T2DM patients. The main data was collected from 281 patients. The self-conducted checklist about knowledge of stroke risk factors, warning signs as defined by national institute of neurological disorder and stroke was prepared in three following parts. 1) Socio-demographic information. 2) Open-ended question about stroke risk factors, warning sign & symptoms and first action information. 3) Multiple choice questions related to the stroke risk factors, warning sign & symptoms and first action information.
Results: 408 T2DM patients were invited and 281 patients fulfilled in study. Most of them (70.4%) were women. The mean age of patients was 54.09±12.54 years. The most common general risk factors of stroke listed were “high blood pressure (92.9%), unhealthy diet” (86.8%), and “stress” (82.2%).The most common sources of stroke information were friends and family members (73.7%).
Conclusion: Education program to increase T2DM knowledge of stroke may contribute to reducing the risk of stroke and increasing the speed of hospital presentation after the onset of stroke.
Zahra Razavi, Hammed Sadri,
Volume 14, Issue 3 (volume 14, number 3 2022)
Abstract

Objective: The role of environmental factors in the development of type1 diabetes mellitus (T1D) is inconclusive. This study aimed to investigate the associations between selected environmental factors and T1D.
Materials and Methods: This group matched case-control study included diabetic and healthy subjects younger than 19 years old in 2017. Cases were diabetic subjects diagnosed before the age of 19 years and controls were healthy subjects with similar distributions of age, sex, and place of living. Information including demographic characteristics, birth season, duration of breastfeeding and major psychological stressors was obtained by a parent-administered questionnaire. Data were analyzed using SPSS version 16 and T-test and chi-square test. Statistical significance was defined as P< 0.05.
Results: The mean age of cases was 12.5 (±5.2) years and 13 (±6.7) in controls (P: 0.55). Compared to controls, children with T1D had a higher chance of having a major psychological stressor in the family before the onset of diabetes (P: 0.0001) with odds ratio (OR) 3.3, higher neonatal jaundice (P: 0.01, OR: 2.25), infection leading to hospitalization within the first year of life (P: 0.007, OR: 6.46), and lower family income (P: 0.018). Duration of breastfeeding was shorter inT1D group (P: 0.018, OR: 3.46) and they had started cereals one month earlier (P: 0.015).
Conclusion: Certain environmental factors including major psychological stressors, neonatal jaundice, infection leading to hospitalization within first year of birth and shorter duration of breastfeeding were associated with the development of T1D.

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