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Showing 11 results for Sheikhpour

Robab Sheikhpour, Bemanali Jalali, Parichehr Yaghmaei, Mohammad Afkhami-Ardekani, Maryam Rashidi,
Volume 2, Issue 2 (4-2010)
Abstract

OBJECTIVE: The present study was performed to compare the antioxidant effect of two different doses of zinc on lipid oxidation in type 2 diabetic patients. MATERIALS AND METHODS: This double-blind, randomized controlled trial was conducted on 60 type 2 diabetic patients in Yazd Diabetes Research Center in 2008. The subjects were randomly allocated to receive Zinc sulfate (Iran, Alhavi) either 220 mg (containing 50 mg zinc) or 110 mg (containing 25 mg zinc) daily for two months. RESULTS: In the present study it was found that serum levels of zinc at the end of trial differed significantly after 50 mg/day zinc supplementation (P = 0.002), but this difference was not observed with dose of 25 mg/day zinc administration. There were no significant differences in the quantitative parameters of serum lipid oxidation after either of two doses of Zinc Sulfate (P > 0.05). CONCLUSION: This study showed zinc supplementation with 50 mg daily for two months could increase serum level of zinc significantly, but we did not observed any change in susceptibility of serum lipid oxidation by 25 or 50 mg zinc supplementation in diabetic patients.
Robab Sheikhpour, Parichehr Yaghmaei,
Volume 4, Issue 1 (5-2012)
Abstract

Diabetes mellitus is one of the major metabolic disorders. It is a global epidemic with an estimated worldwide prevalence of 6% (246 million people) in 2007. Diabetes is recognized for severe complications including diabetic nephropathy, neuropathy, and retinopathy. Currently, available therapy acts by increasing insulin secretion (sulphonylurea and glinides), decreasing insulin resistance (glitazones and metformin) or delaying the absorption of glucose from the intestine (acarbose). Insulin treatment is expensive and induces weight gain. None of these drugs have been shown to stop the progressive decline of beta-cell function. Many traditional plant treatments exist as a hidden wealth of potentially useful natural products for diabetes control. There are approximately 800 to 1200 plants that exhibit hypoglycemic activity. Herbal medicine represents one of the most important fields of traditional medicine all over the world and provides a valuable alternative therapeutic. Herbal medicines are frequently considered to be less toxic and free from side effects rather than synthetic ones. Many plants like Citrullus colocynthis, fenugreek and ginger are useful in diabetes. The hypoglycemic properties of the plants are surveyed in this paper such as Citrullus colocynthis, fenugreek, and ginger.
Robab Sheikhpour, Bemanali Jalali, Mohammad Afkhami-Ardekani,
Volume 4, Issue 2 (6-2012)
Abstract

Objective: Diabetes is the most common metabolic disease. One of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which induced by hyperlipidemia. Also there has been currently great interest in the potential contribution of oxidative stress in development of diabetes complications. The present study was performed to associate between lipid oxidizability and serum lipid levels in diabetic patients. Materials and Methods: In this study, 55 diabetic patients in Yazd Diabetes Research Center were chosen. Lipid oxidizability, HbA1c and serum lipid levels were analyzed in patients. Lipids were measured by enzymatic method. HbA1c was estimated by the ion exchange chromatography. The lipid oxidation procedure was performed by addition of CuCl2. The kinetics of conjugated dienes formation was monitored by spectrophotometer and parameters such as ODmax, Lag Time, Vmax and Tmax were analyzed. Result: In present study, there was no association between lipid oxidizability and serum lipids levels. Also there was no association between lipid oxidizability parameters and HbA1c. Conclusion: This study showed that high levels of blood lipids such as cholesterol and triglyceride do not have any effect on maximal amount of lipids peroxide products accumulation and maximal rate of oxidation during the lipid oxidation course.
Robab Sheikhpour, Fatemeh Sadeghian, Fatemeh Pourhosseini, Shokouh Rajabi,
Volume 5, Issue 1 (volume 5, number 5, spring 2013)
Abstract

Abstract Objective: Diabetes mellitus is the most common metabolic disease. One of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which is induced by hyperlipidemia. Impaired lipid metabolism resulting from uncontrolled hyperglycemia has been implicated in cardiovascular complications in diabetic patients. Also, glycated hemoglobin (HbA1c) has been regarded as an independent risk factor for cardiovascular disease. The aim of this study was to examine the correlation between HbA1c, fasting blood sugar (FBS) and 2 hours postprandial glucose (2hpp) with serum lipid levels in type 2 diabetes. Materials and Methods: In this study, 100 diabetic patients in Yazd Diabetes Research Center were chosen. FBS, 2hpp, HbA1c and serum lipid levels were analyzed in patients. Serum Lipids and glucose were measured by enzymatic method. HbA1c was measured by DS5 analyzer and DS5 Pink Reagent kit. Results: There was significant correlation between FBS and total cholesterol (TC) (r=0.25, P=0.039), 2hpp with TC (r=0.338, P=0.033) and 2hpp with LDL (r=0.39, P=0.01), but there were no correlations between HbA1c and TC (r=0.2, P=0.06), HbA1c and triglyceride (P=0.2, r=-0.14), HbA1c and HDL (P=0.25 r=-0.14) and HbA1c with LDL (P=0.08, r=0.2). Conclusion: The results of this study showed that the high levels of serum glucose are associated with high levels of cholesterol and LDL and can be a risk factor for cardiovascular diseases.
Robab Sheikhpour,
Volume 5, Issue 1 (volume 5, number 5, spring 2013)
Abstract

Abstract Diabetes mellitus is one of the major metabolic disorders. Diabetes is recognized for severe complications including diabetic nephropathy, neuropathy and retinopathy. Long-lasting effect of hyperglycemia results in increased oxidative stress. Oxidative stress results from an imbalance between radical-generating and radical scavenging systems. Increased oxidative stress has been shown to be increased in both insulin-dependent (IDDM), and noninsulin-dependent (NIDDM) diabetes mellitus and it could cause initial β cell damage in type I diabetes, or impaired insulin production, release or function in type II diabetes. Therefore, people with diabetes may also have greater antioxidant requirements because of increased production of free radicals in hyperglycemia. In this article, oxidative stress, free radicals, antioxidants and various mechanisms of reactive oxygen species (ROS) formation such as polyol pathway, protein oxidation, advanced glycation endproducts and lipid peroxidation in diabetic patients will be surveyed.
Robab Sheikhpour, Arezoo Khoradmehr,
Volume 6, Issue 1 (volume 6, number1 2014)
Abstract

Abstract Alzheimer’s disease (AD) is the most common cause of dementia in elderly people. The prevalence of Alzheimer diseases is increasing in the world due to population aging. Metabolic disease such as diabetes and obesity play important role in Alzheimer disease. Hyperglycemia can play important role in brain damage. It causes cognitive impairments, functional and structural alterations in the brain. Since insulin has neuro protective effect in vivo, impaired insulin action in brain may affect neurodegenerative diseases. Obesity correlated increased free fatty acid can lead to Alzheimer disease. Free fatty acids agitate the synthesis of amyloid and tau filaments in vitro. In this paper, Alzheimer disease and its mechanism are discussed in section 1. In section 2, diabetes and Alzheimer, brain insulin signaling pathway in AD are explained. Obesity and Oxidative stress in AD are discussed in section 3, 4.
Razieh Sheikhpour, Mehdi Agha Sarram,
Volume 6, Issue 2 (volume 6, number2 2014)
Abstract

Objective: Diabetes is one of the most common metabolic diseases. Earlier diagnosis of diabetes and treatment of hyperglycemia and related metabolic abnormalities is of vital importance. Diagnosis of diabetes via proper interpretation of the diabetes data is an important classification problem. Classification systems help the clinicians to predict the risk factors that cause the diabetes or predict people who are at risk of developing diabetes. Materials and Methods: In this study, Pima Indian diabetes dataset taken from the UCI machine learning repository was used which contains 786 samples of normal and diabetes with 8characteristics.Selection of efficient features of this dataset was analyzed using correlation criterion, information gain and CfsSubsetEval. Then diagnosis of diabetes diseases on Pima dataset was considered using proposed by-level dimensionality reduction method and classification algorithms. Classification algorithms used in this study are KNN, quadratic, Naïve Bayes, nearest mean classifier, non-parametric Gaussian and Mahalonobis kernel and linear discriminant. Results: In all feature selection methods, plasma glucose concentration a 2-hours in an oral glucose tolerance test, body mass index and age have been selected as the top-ranked features in intelligent diagnosis of diabetes. Proposed method has achieved the accuracy of 82.09 using KNN and quadratic methods and bi-level dimensionality reduction on Pima dataset. The best performance has been achieved by performing PCA algorithm on the features, namely, number of pregnancy, plasma glucose concentration a 2 hours in an oral glucose tolerance test, body mass index, diabetes pedigree function and Age. Conclusion: The results of this study showed that bi-level dimensionality reduction and classification algorithm scan be very helpful in assisting the physicians to diagnosis diabetes.
Robab Sheikhpour, Maryam Chinisaz, Sepideh Jabbari,
Volume 6, Issue 3 (volume 6, number3 2014)
Abstract

Apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. It is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. Pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 and type 2diabetes. There are several reasons through which apoptosis can be induced in β-cell. Metabolic abnormalities such as hyperlipidemia and hyperglycemia have been cited as critical mediator of cell death and may either trigger β-cell apoptosis. Persistent hyperglycemia causes increased production of free radicals that can damage initial β-cell in type I diabetes, impaired insulin production, release or function in type II diabetes. Also apoptosis plays an important role in several diabetic complications. The role of metabolic factors and their mechanism in β-cell apoptosis have been surveyed in this paper.
Robab Sheikhpour,
Volume 7, Issue 2 (volume 7, number2 2015)
Abstract

Fetuin-A is a phosphorylated glycoprotein produced by liver.It by binding to calcium ion inhibits ectopic calcium deposition and protects vascular calcification. Fetuin-A acts as a multifactorial protein and its role has been documented from brain development to bone remodeling and immune function, regulation of insulin activity, hepatocyte growth factor activity and inhibition lymphocyte blastic transformation. Fetuin-A inhibits phosphorylation of insulin receptors in liver and muscle resulted to decreased insulin signaling, therefore, the high level of fetuin-A is associated with insulin resistance and incidence of type 2 diabetes. Also fetuin-A suppresses tyrosin kinase activity in muscle and liver via inhibiting the auto phosphorylation of this enzyme and insulin receptor substrate proteins (IRS-1). Obesity also increases fetuin-A gene expression, indicating an important role of fetuin-A in predisposing to obesity. Also increased fetuin-A and plasma levels of proteins expression are associated with fat accumulation in liver. In this paper, Fetuin-A, its role in diabetes and insulin resistance, Fetuin-A, obesity and cardiovascular will be surveyed.


Sodabeh Farahnak, Robab Sheikhpour, Foad Iranmanesh,
Volume 7, Issue 4 (volume 7, number4 2015)
Abstract

Diabetes mellitus is a group of metabolic diseases caused by a combination of insulin resistance and impaired insulin secretion by pancreatic β cell. In 2007, 246 million people (roughly 6%) were affected by diabetes worldwide and it is estimated that this will increase to 380 million in 2025. Diabetes is associated with several long-term complications such as cardiovascular disease, nephropathy, retinopathy, neuropathy and some oral complications. In addition, Diabetes mellitus causes an increased risk of morbidity because of infection disease. It seems that, the increased frequency of infections associated with Immunoglobulin-A (IgA) deficiency in these patients. Therefore a low IgA secretion rate is suspected to be one of these mechanisms. Moreover, it shows a main antiviral activity by neutralizing toxins and viruses. It by inhibiting the attachment and replication of pathogenic microorganisms prevents colonization of these pathogens.Therefore, it acts as a first line of defense against pathogens and early detection of immunoglobulin A deficiency in diabetic patients can prevent the vicious cycle of recurrent infections and reduces risk for morbidity and metabolic decompensation. Moreover, the Salivary-IgA is the widespread immunoglobulin in mixed saliva and is assumed to be an important factor for adaptive immunity in the oral cavity. Therefore, according to these studies, Immunoglobulin A, its mechanism, IgA deficiency and diabetes and its relation with oral complications are explained in this paper.


Robab Sheikhpour,
Volume 8, Issue 2 (volume 8, number 2 2016)
Abstract

Diabetes mellitus is a group of metabolic diseases. Insulin resistance is defined as a state that needs more insulin to get the biological effects achieved by a lower amount of insulin in the normal state. Several molecules which are secreted through adipocytes have been involved in insulin resistance and type 2 diabetes mellitus. Adiponectin as a 244 amino acid protein is exclusively expressed in differentiated adipocytes. Recent studies indicated impaired multimerization of adiponectin is associated with type 2 diabetes development. Moreover, the relationship between adiponectin, insulin and insulin resistance is not known and many mechanisms have been proposed. Inverse relationship between adiponectin and insulin resistance may be mediated through insulin and other hormones like catecholamines or androgens. Moreover, intensive insulin treatment increased serum C-peptide and adiponectin level resulted to improving sensitivity of insulin and decreased CRP level. According to these studies, it seems that adiponectin may be an important modulator of insulin action for enhancing of sensitivity of insulin.



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