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Showing 7 results for Vakili

Fereshteh Ahmadipour, Tahereh Vakili, Abdolrahim Absalan, Javad Mohiti-Ardakani, Hosein Hadinedoushan, Mohammadali Khalili, Fatemeh Pourrajab,
Volume 4, Issue 4 (volume 4, number 4, winter 2012)

Objective: GLUT4 is a type of glucose transporter and plays a central role in whole-body metabolism of carbohydrates. The muscle is the major site of GLUT4 and cell line models, to explore GLUT4 behaviors under new therapeutic approach, such as herbal components, should be evaluated. Here, C2C12 cell line is evaluated for GLUT4 translocation from intracellular compartment into the cell membrane. Materials and Methods: C2C12 cell lines were cultured and differentiated into myotubes. Cinnamon/Turmeric-water soluble extract (CWE and TWE) were prepared and differentiated myotubes were exposed to the 100, 1000 μg/ml CWE, 100 μg/ml TWE or dimethylsulfoxide for 3 hours. Intracellular/cytoplasmic membrane compartments were separated using ultracentrifugation. GLUT4 percentages quantities were measured using western blotting. Data analysis of 3 sample sizes was done by comparing mean±SD of GLUT4 quantities and independent samples t-test. Results: CWE enhances GLUT4 translocation from intracellular compartment into the cytoplasmic membrane its effect is also dose-dependent meaning that 1000 μg/ml concentration has a more potent effect than 100 μg/ml (p<0.05). However, 100 μg/ml TWE had a reverse effect (p<0.05). Conclusion: Here we have shown that C2C12 is a good model for exploring GLUT4 changes under the effect of herbal extract. Induction or blockade of GLUT4 maybe under control of different signals transduction pathways. Furthermore, although turmeric ingredients are declared to have somewhat anti-diabetic effects, here we have shown that such effect is not applied via TWE effects on GLUT4 intracellular compartments movement into the cell membrane.
Arezoo Aghakoochak, Ahmad Shojaoddiny-Ardekani, Mahmood Vakili, Nasim Namiranian,
Volume 6, Issue 1 (volume 6, number1 2014)

Objective: Quality of life (QOL) is an intellectual concept consisting of positive and negative aspects of an individual’s life and indeed it demonstrates the method by which a person perceives the health condition as well as the other aspects of his/her life and reacts to them. Currently, assessment of QOL is more considered because of the increased prevalence of chronic diseases. So, the current study was conducted to assess the QOL in type 2 diabetic patients compared to non-diabetic subjects. Materials and Methods: A case-control study was conducted in Yazd Health Monitoring Research Center on 50 diabetic patients and 50 healthy people in March2014.The data collection instrument had two parts: 1-demographic and disease related check list 2- Persian validated and reliable version of SF-36.Descriptive and multivariate statistics were done with the statistical software SPSS-17 (Chicago, IL, US) Results: 50 participants were included in case and control groups. Fifty percent of patients were female and most of them (42%) were between 41-60 years old. The mean ± standard deviation of quality of life score in cases and controls were 54.95±13.17 and 68.87±28.57 respectively. The mean of quality of life score in physical functioning, vitality, role emotional, social functioning and bodily pain domains were significantly different between case and control groups. Conclusion: Our study showed lower levels of QOL in diabetic patients in comparison with control group. This is in agreement with previous studies and may be related to complications of DM, or numerous problems which diabetic patients encounter. Improving of QOL by appropriate education and follow-up must be emphasized to the management of diabetic patients.
Saeedeh Alsadat Heidari, Mahmood Vakili, Nasim Namiranian,
Volume 7, Issue 3 (volume 7, number3 2015)

Objective: Studies reported conflicting results’ regarding the status of depression and glycemic control in patients with type II diabetes(T2DM), therefore, this study was performed to determine the relationship between depression and glycemic control in T2DM patients.

Materials and Methods: This cross-sectional study was performed on 150 T2DM patients referred to Yazd diabetes research center, 2014. Data were collected by using Beck Depression Inventory. Data collected were analyzed by SPSS-21 with using descriptive statistics and analytical testing at α=0.05.

Results Mean and standard deviation (SD) of age, disease duration and HbA1c levels respectively were; 58.18±9.63 years, 10.83±6.01 years and 8.52±1.59 mg/dl. About 97 patients (64.7%) were women, 88 (58.7%) had hypertension, 57 (38%) hyperlipidemia, 28 (18.7%) good glycemic control. There was no significant relationship between depression status and HbA1c control, hypertension, hyperlipidemia, insulin type and disease duration. Patients with moderate depression status and women had significant relationship with macrovascular complications.

Conclusion: Despite the lack of significant relationship between depression status and HbA1c control and given the significant relationship between moderate depression status and HbA1c control with macrovascular complications, it seems are needed more extensive studies.

Azam Ghaneei, Safar Ali Dehghani, Azimeh Kadkhodazadegan Yazd, Mahmood Vakili,
Volume 7, Issue 3 (volume 7, number3 2015)

Objective: In patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. We designed a study for comparing the level of Ox-LDL in diabetic patients with Macro-albuminuria, Micro-albuminuria, versus Normo-albuminuric.

Materials and Methods: One hundred and thirty five patients with type 2 diabetes mellitus who had been referred to the Yazd Diabetes Clinic, from 1391 through 1392, were enrolled to our study. The 24 hours urinary albumin excretion was measured and Macro-albuminuria defined as albumin excretion of greater than 300mg per day and below 30mg per day in normo-albuminuric group and between 30-300mg defined as Micro-albuminuria group. Plasma level of OX-LDL was measured.

Results: The plasma OX-LDL level in patients with Macro-albuminuria was higher than those in Normo-albuminuric group, (16.1±3.6 U/ml versus 8.6±1.7 U/ml). There was a significant correlation between the OX-LDL and urine albumin in Macro-albuminuria and Micro-albuminuria groups. There was no significant correlation between the OX-LDL and HbA1C level and diabetes duration.

Conclusion: Significantly elevated plasma OX-LDL in patients with Macro-albuminuria suggests that OX-LDL may play an important role in the progression of diabetic nephropathy.

Mahmood Vakili, Akram Ghadiri-Anari, Ahmad Azizollahi, Maryam-Sadat Torabipour,
Volume 8, Issue 1 (volume 8, number 1 2016)

Objective: The high prevalence of Gestational Diabetes Mellitus (GDM) in Iran and its maternal and fetal consequences as well as the high risk of its long-term effects including obesity is known. The aim of this study was to evaluate the relationship between body mass index (BMI) in ages of 18 months and 6 years and maternal glucose concentration.

Materials and Methods: This is a retrospective cohort study conducted on 199 pairs of mother and child in five health-care centers of Yazd. The children born in 2007 and 2008 were selected, followed by a calculation of BMI in the ages of 18 months and 6 years (school age) based on their heights and weights recorded in their family files. The relationship between the resulting BMI and maternal glucose concentration and pregnancy conditions was then determined.

Results A population of 199 mother-child pairs were investigated consisting of 105 male children (52.8%) and 94 female ones (47.2 %). The mean (±SD) glucose challenge test (50 gram -GCT) and pre-pregnancy BMI were 121(25.7) mg/dL and 24.16 (4.85) kg/, respectively. At 18 months, the mean (±SD) child BMI was 15.78 (1.21) kg/, 5.5% of which were overweight/obese and at 6 years, the mean (±SD) child BMI was 14.46 (1.81) kg/, 12.6% of which were overweight/obese. This study revealed a significant association between BMI 18 months and 6 years and pre-pregnancy BMI with maternal GCT (P-value <0.003). Therefore, GCT ≥ 130 mg/dL compared with GCT <129 mg/dL significantly associated with BMI at 18 months and 6 years old and the mother's pre-pregnancy BMI.

Conclusion: According to this study, it can be concluded that there is a significant correlation between GCT and the increase of children BMI. It is necessary to control and treat gestational diabetes mellitus by means of decrease the intergenerational cycle of obesity and diabetes in offspring. Also infants of women with diabetes should be specifically targeted for obesity prevention programs.

Reyhane Azizi, Simin Manoochehry, Seyd Kazem Razavi-Ratki, Seyed Mostafa Seyed Hosseini, Mahmoud Vakili, Nasim Namiranian,
Volume 8, Issue 4 (volume 8, number 4 2016)

Objective: Blood group as a genetic trail can be associated with type 2 diabetes. The aim of this research was to determine the distribution of ABO frequency and RH blood groups in type 2 diabetic patients referred to Yazd diabetes center.
Materials and Methods: In this research 1502 type 2 diabetes patients of Yazd diabetes center were selected and checked for blood group ,age, sex, duration of diabetes, nephropathy, retinopathy ,diabetes control and familial history of diabetes. Data were analyzed on SPSS-21.
Results: From 1502 patients participated in this study 995 were male (66.2%) and 507 female (33.8%). The mean age (standard deviation) of patients was 52±10.46. About 541 participants (36%) had O blood group, 431 (28%) A, 379 (25%) B, and 150 (10%) AB. About 90.8% patients were RH. The most frequency was observed in blood group O+ (30.9%) and the patients with blood group of AB- had the lowest frequency (0.5%) among patients. The various blood groups were not different in following subgroups; Familial History (P=0.6), diabetes duration (P=0.32), retinopathy (P=0.64), nephropathy (P=0.69), and hypertension (P=0.33). But HbA1c<7 and blood groups were significantly different (P=0.03).
Discussion: The blood group O+ was the most frequent and AB- was the  least frequent among blood groups in this study .But for evaluation of  relationship between blood group and diabetes the prospective studies are suggested.

Yasaman Shahriari, Sogand Ghasemzadeh, Leila Kashani Vahid, Samira Vakili,
Volume 14, Issue 3 (volume 14, number 3 2022)

Objective: The parent-child relationship and the daily blood sugar control by adolescents can affect family functioning. This study aimed to evaluate the effectiveness of unified trans-diagnostic treatment protocols on parent-child interaction and blood sugar levels in adolescents with type 1 diabetes.
Materials and Methods: The present study was quasi-experimental with a pretest and posttest design and a control group. The statistical population of the study included all adolescents aged 12-15 years with type 1 diabetes referred to the Iranian Diabetes Society and their parents in 2020. Out of this population, 44 were selected using the convenience judgmental sampling method and randomly divided into two groups (n= 22). The Child-Parent Relationship Scale (CPRS) was used to investigate the parent-child interaction, and hemoglobin pre-and post-program tests were used to assess blood sugar. Adolescents and parents in the experimental group received the program during 17 sessions. Data were analyzed using the analysis of covariance. Statistical analyses were performed by SPSS software version 22.
Results: The means of corrected post-test scores of the Child-Parent Relationship Scale and hemoglobin A1c tests were significantly different in the experimental and control groups (P= 0.001).
Conclusion: The unified trans-diagnostic treatment protocols affect parent-child interaction and blood sugar levels in adolescents with type 1 diabetes. It is possible to use this program to educate adolescents with diabetes and their families and preventive interventions.

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