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Showing 15 results for Aerobic Training

Morteza Taghavi, Mohammad Ali Sardar, Fahimeh Ayyaz, Hale Rokni,
Volume 3, Issue 1 (4-2011)
Abstract

OBJECTIVE: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age characterized by the presence of polycystic ovaries, menstrual dysfunction and biochemical or clinical hyperandrogenism. Lifestyle modification is important in treatment of obese and overweight women with PCOS. This study was performed to evaluate the benefit of aerobic exercise training on obesity and insulin resistance in young women with PCOS. MATERIALS AND METHODS: Twenty obese PCOS patients aged 15-30 underwent a 12-week aerobic training program. Anthropometric parameters (weight, height, maximum oxygen consumption, waist circumference, waist to hip ratio and body fat percentage), metabolic and hormonal profiles (glucose and insulin) were assessed and compared at the baseline and after the 12-week training program. RESULTS: After a 12-week aerobic training program body weight decreased from 76.9 ± 11.69 to 74.01 ± 11.82 Kg, body fat percentage decreased from 37.01% ± 4.16 to 35.57% ± 4.13 and waist circumference decreased from 86.4 ± 8.75 to 82.29 ± 6.59 cm (P < 0.05). There was also a significant increase in V02max, from 34.77 ± 1.86 to 35.87 ± 1.94 (P = 0.006). Changes in fasting glucose, fasting insulin, and insulin resistance were not significant. CONCLUSION: Aerobic training program improves anthropometric parameters, and metabolic and hormonal profiles in young women with PCOS.
Mania Roozbayani, Maghsoud Peeri, Hamid Agha-Alinejad, Mohammad Ali Azarbayjani,
Volume 8, Issue 4 (12-2016)
Abstract

Objective: High intensity interval training (HIIT) and continues aerobic training have cardio-protective effects in diabetic rats. The aim of this study was to compare the effect of HIIT and continues aerobic training (CAT) on MIR29A and collagen I gene expression in heart of diabetic male rats.
Materials and Methods: In this randomized controlled clinical trial, 18 male diabetic rats were studied. They were divided into 3 groups as HIIT, CAT and control group. Exercise protocol was performed 5 days/week for 5 weeks. The MIR29A and collagen I synthesis were compared between the groups.
Results: Findings showed MIR29A expression is statistically higher in HIIT and CAT group than control group (P-value<0.001) and (P-value:0.053). Also MIR29A expression is significantly higher in HIIT group compared to CAT group (P-value:0.034). Collagen I expression was significantly lower in HIIT and CAT group compared to control group (P-value<0.001) and (P-value:0.001). Collagen I expression was lower in HIIT group compared to CAT group (P-value:0.027).
Discussion: The results of this study demonstrated that, HIIT increases MIR29A expression which is along with reduction in collagen I synthesis in cardiac muscles increases the risk of myocardial fibrosis in diabetic rats.

 
Hojjatollah Siavoshy, Ali Heidarianpour,
Volume 9, Issue 1 (6-2017)
Abstract

Objective: Type 2 diabetes(T2DM) patients can ben­efit from exercise training programs but there are many barriers to do exercise .The aim of this study was to investigate effects of 10 weeks aerobic, resistance and combined strength and aerobic exercise program on fasting blood sugar (FBS) and glycated hemoglobin (HbA1c) of T2DM male patients.
Materials and Methods: A quasi experimental study on 52 T2DM male patients was done. They were divided into four groups: aerobic training group (ATG; n=13), resistance training group (RTG; n=13), combined strength and aerobic training group (SAG; n=13), and control group (CG; n=10). There were three types of training program: aerobic, with intensity of 55-85% of the heart rate maximum (HRmax) 3 times /week, and resistance, with intensity of 50-75% one-repetition maximum 3 times week. Anthropometric measurements, HbA1c and FBS were measured at the beginning and after 10 weeks.
Results: The mean (± standard deviation) age of participants was 53.24 (±1.05) years old. FBS decreased significantly in all studied groups (P-value<0.05); and HbA1c decreased significantly in RTG and SAG groups (P-value<0.05), but, there were no significant differences in HbA1c between groups.
Conclusion: The result of the present study indicated that three type exercise training programs cause improving the metabolic factors related to diabetes in T2DM male patients. However, each type of training also provides unique benefits.
Mehrzad Shaabani, Farzaneh Abolfathi, Ali Akbar Alizadeh,
Volume 9, Issue 4 (12-2017)
Abstract

Fatty liver disease is one of the most common diseases in women with type II diabetes. While regular exercise can decrease the complication of this disease, it was not clearly identified. The aim of this study was to evaluate the effect of four weeks aerobic training on Liver Transaminases and some glycemic markers in women with type II diabetes.Materials and Methods: In this study, 20 patients with type II diabetes were participated in two groups (experimental and control group). The experimental group did the continuous aerobic training and running on treadmill with 55 to 80 percent of their maximum heart rate for five times a week during the four weeks. The blood samples were prepared in two pre-test and post-test steps to measure the levels of liver transaminases, glucose and insulin through ELISA method.
Results: Statistical analysis showed that after four weeks of aerobic training, the liver inflammatory markers, glucose and insulin related to the experimental group had no significant difference in comparison with control group (P>0.05).
Conclusion: The results indicated that doing the continuous aerobic training five times a week during four weeks with 55 to 80 percent of maximum heart rate, do not diminish liver transaminases, glucose and insulin in women with type II diabetes.
 
Mohammad Hashemi, Farhad Rahmaninia, Mohamad Ali Azarbaijani, Manuchehr Soltani,
Volume 9, Issue 4 (12-2017)
Abstract

Objective: The reasons that some of these studies have offered for aerobic training’s lack of tangible effect on the level of angiogenesis, are subjects’ readiness and the conditions of their diseases, while others have detected the intensity and the frequency of doing the aerobic trainings as the factors preventing the effectiveness of them on the level of angiogenesis. Thus, the present study studied the effects of taking interval and continuous aerobic trainings on the degrees of angiogenesis and nitric oxide.
Materials and Methods: Sixty eligible old men in Kahrizak nursing home among volunteers were selected and studied in three groups (Continuous, Interval and Control). First, the initial blood samples were gathered to record of serum WEGF by ELISA kit. In the second stage NO in saliva were measured by conversion of nitrate to nitrite and by Griess reaction. After the 48 hours, experimental group in both continuous and interval carried out training for 6 weeks and the control group continued their daily activities. Post-test data measured and recorded in the same conditions with the pre-test. Obtained data were analyzed by using one-way ANOVA, Scheffe post hoc and dependent T-test.
Results: The results showed that WEGF serum and salivary NO levels after performing the aerobic training to both continuous and interval methods was not any significantly different (P>0.05). However, the percentage change recorded data for the experimental group than in the control group despite the lack of significant difference of nearly a significant increase in the WEGF serum and saliva levels of NO were observed (No: Continuous and Interval≈ 0/05 increase, Control: 0/01 increase, VEGF: Continuous= 0/03 Increase, Interval= 0/05 Increase, Control= 0/02 Decrease). According to the paradox observed in obese and diabetes subjects can be said that apply the aerobic training in elderly subjects with such conditions requires specific design and likely to be that the implementation of traditional aerobic trainings will not have a significant effect on the WEGF serum and NO saliva levels.
Conclusion: In the present study, we found that doing aerobics training in both continuous and interval courses had no significant effects on the level of angiogenesis and nitric oxide in the old men under study. However, we can maintain that taking aerobic trainings by subjects who suffer from diabetes, hypertension and obesity, based on results from previous studies has no positive effects. Patients suffering from diabetes, hypertension and obesity would see no significant change in their angiogenesis rate after doing continuous or interval aerobic trainings.
 
Ali Fakourian, Homaee Hasan Matin, Mohammad Ali Azarbayjani, Parvin Farzanegi,
Volume 11, Issue 2 (6-2019)
Abstract

Objective: Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL2 and some mitochondrial enzymes of the kidney in diabetic rats.
Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were simple randomly divided into six groups: 1) placebo group, 2) healthy control group, 3) diabetic control group, 4) diabetic group receiving L- carnitine, 5) diabetic group of aerobic training and 6) diabetic group of aerobic training and recipient of L-carnitine. Rats with a serum glucose level higher than 300 mg/ dL were considered diabetic. L-carnitine recipients received 100 mg of L-carnitine daily orally. The dependent variables of the study were measured 24 hours after the last training program session by ELISA in kidney tissue. Data were analyzed by Shapiro- Wilk and two way ANOVA and Tukey post hoc test at P-value< 0.05.
Results: The results showed that the combined effect of aerobic training and supplementation of L-carnitine on Bcl2 factor of kidney tissue of rats with diabetes has a significant effect (P-value: 0.019). But aerobic exercise (P-value: 0.969) and supplementation of L-carnitine (P-value: 0.584) were not significant.
Conclusion: The results of this study showed that the combined effect of aerobic exercise and supplementation of L-carnitine on CPT2 and Malonyl COa and Bcl2 have a significant effect on the kidney of diabetic rats. Also, exercise alone and consumption of L-carnitine alone do not have a significant effect.
Javad Ramezani, , Mohammad Ali Azarbayjani, Maghsoud Peeri,
Volume 11, Issue 4 (12-2019)
Abstract

Objective: Aerobic training and berberine chloride include antioxidant characteristics. In this study, aerobic training and berberine chloride intervention on the activity of antioxidant enzymes and lipid peroxidation of pancreatic tissue were investigated in type 1 diabetic male wistar rats.
Materials and Methods: In the current study, 56 Wistar male rats were randomly assigned to seven different groups (n= 8), these groups include healthy control, diabetic control, Berberine-treated diabetes (15&30 mg/kg), aerobic training-treated diabetes, Diabetes treated with Berberine and aerobic training (15&30 mg/kg). The aerobic training schedule consisted of 6 weeks treadmills with a frequency of 5 sessions per week. The Berberine was also fed a specific dose every day and a half before training. The superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were assessed using ELISA method.
Results: The results showed that aerobic training, as well as the intervention of Aerobic Training and Berberine chloride, had a significant effect on the increase of antioxidant enzymes SOD and CAT in the pancreatic tissue groups (P-value< 0.05), but did not significantly affect the GPX level (P-value> 0.05). There was a significant decrease in MDA level in all treatment groups (P-value< 0.05). In diabetic groups that received both treatments at the same time, the MDA level more decreased (P-value< 0.0005).
Conclusion: The aerobic training and berberine chloride concurrent intervention have a greater effect on the antioxidant enzymes in the pancreatic tissue of diabetic specimens. Therefore, it is recommended that aerobic training be done with berberine chloride.
Seyed Esmaeil Jabbari, Mandana Gholami, Hojatollah Nikbakht, Nader Shakeri, Farshad Ghazalian,
Volume 12, Issue 1 (3-2020)
Abstract

Objective: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and L-carnitine supplementation on some of the oxidative stress factors in the liver of diabetic rats.
Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving L-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving L-carnitine. The aerobic exercise protocol included six weeks, five sessions per week on the treadmill. After intervention, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX) levels were determined in liver tissue.
Results: Six weeks of aerobic exercise had a significant effect on MDA factor in hepatic tissue in diabetic rats (P-value: 0.024). However, supplementation (P-value: 0.868) and combined intervention of aerobic exercise and supplementation of L-carnitine (P-value: 0.465) did not have the significant effect on MDA factor. Also, 6 weeks of aerobic training, supplementation of L-carnitine, and combined intervention had no significant effect on SOD and GPX factors of hepatic tissue in diabetic rats (P-value> 0.05).
Conclusion: L-carnitine supplementation with regular exercise can have beneficial effects on hepatic antioxidant defense system in rats with type 2 diabetes.
Milad Rahimi, Mohammad Ali Azarbayjani, Maghsoud Peeri, Parvin Farzanegi,
Volume 12, Issue 1 (3-2020)
Abstract

Objective: Physical exercise has different effects on oxidative stress. Oxidative stress influences TLR4 and NFkB gene expression. The purpose of this study was to investigate the effect of aerobic training and vitamin D on gene expression of TLR4 and NFkB in lung tissue of obese rats exposed to oxygenated water.
Materials and Methods: In an experimental study, 30 obese male wistar rats were randomly divided into five groups: control, oxygenated water, oxygenated water + vitamin D, oxygenated water + aerobic training, and oxygenated water + aerobic training + vitamin D. All the rats were injected intraperitoneally with oxygenated water. Vitamin D was performed by intraperitoneal injection of 0.5 μg daily for eight weeks. The aerobic training protocol included 8 weeks, 5 sessions per week running on treadmill. TLR4 and NFkB gene expression of lung tissue were investigated using real time & PCR. Two-way ANOVA and Bonferroni post hoc test were used to analysis the data. The significant level was set at P-value< 0.05.
Results: Aerobic training significantly reduced TLR4 expression compared with other groups (P-value: 0.046) but did not significantly affect the expression of NFkB gene (P-value: 0.261). Vitamin D alone and aerobic training and vitamin D interaction did not significantly alter the gene expression of TLR4 (P-value: 0.072 and P-value: 0.695, respectively) and NFkB (P-value: 0.243 and P-value:< 0.195, respectively).
Conclusion: It seems that performing aerobic training is likely to be beneficial in reducing oxidative stress and inflammation compared to inactivity.
Ashraf Amini, Zahra Mirakhori, Mojtaba Eizadi,
Volume 12, Issue 2 (6-2020)
Abstract

Objective: Obesity is associated with inflammatory process and many different diseases. The objective of this study was to assess the impact of short term aerobic training on serum resistin and insulin resistance in adult obese women.
Materials and Methods: In this quasi-experimental study, thirty untrained adult obese females matched for age 35-45 years old with body mass index (BMI) 30-36 kg/m2 were divided randomly into exercise (aerobic intervention; 6 weeks, 3 days/weekly, %55-70HRmax) and control (no training) groups. Pre and post-training of fasting blood samples were collected for measure serum resistin. Insulin resistance was calculated by HOMA-IR. Data were analyzed by the independent samples T-test.
Results: Aerobic training resulted in significant decrease in BMI (32.1 (± 2.76) vs 31.6 (± 2.80) kg/m2, P-value: 0.023), body fat percentage (44.7 (± 4.55) vs 44 (± 4.33), P-value: 0.028) and fasting glucose (94 (± 8.9) vs 79 (± 5.8) mg/dl, P-value: 0.011) in exercise group. No changes were observed on insulin resistance (1.43 (± 1.11) vs 1.18 (± 0.57) HOMA-IR, P-value: 0.124) and serum resistin (2.20 (± 1.07) vs 1.58 (± 0.87) ng/ml P-value: 0.062) by training program. All variables remained unchanged in control subjects.
Conclusion: Despite improving fasting glucose, a short-term aerobic training is not associated with anti-inflammatory property for obese females. Improved glucose could be likely attributed to other changes in metabolic markers in response to exercise training and further studies are necessary to clarify possible mechanisms.
Fariba Bakhtiari, Hasan Matin Homaee, Farshad Ghazalian,
Volume 12, Issue 2 (6-2020)
Abstract

Objective: The goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (TNF-α), hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats.
Materials and Methods: In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), diabetic aerobic training, diabetic control and healthy control (n=10). Induction of type 2diabetes (T2DM) was done by intraperitoneal infusion of streptozotocin. The progressive aerobic training protocol entailed 4 weeks, 5 sessions per week running on treadmill at velocity of 20 m/min for 60 min. The gene expression of TNF-α, VEGF and HIF-1α were measured by real time & PCR. One way analysis of variance and bonferroni test were applied to analysis the data. The significant level was set at P-value< 0.05.
Results: The results indicated that the aerobic training induced significant decrease in TNF-α mRNA (P-value< 0.001) and significant increase in HIF-1α mRNA (P-value< 0.001) and VEGF mRNA (P-value< 0.001) compared to diabetic control group.
Conclusion: It appears that aerobic training with reduction of TNF-α issues an affirmative effect on angiogenesis, as a result, it improves diabetic cardiac.
Shokoufeh Sokhanvardastjerdi, Abdolali Banaeifar, Sajad Arshadi, Aredeshir Zafari,
Volume 12, Issue 2 (6-2020)
Abstract

Objective: The aim of this study was to investigate the effect of 12 weeks aerobic training on PDX-1 and GLUT2 gene expression in the pancreatic tissue of type 2 diabetic rats.
Materials and Methods: 21 wistar male rats were placed in 3 groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted 12 weeks, five sessions per week by gradual increase of speed (18 to 26 meters on minutes) and time (10 to 55 minutes) in the form of running on the treadmill. After 12 week aerobic training, PDX-1 and GLUT-2 genes were measured. Data was analyzed using ANOVA with 5 % significance level.
Results: Aerobic training caused a significant increase in the expression of GLUT2 (P-value: 0.043) and PDX-1 genes (P-value: 0.007) in the pancreatic tissue of rats with type 2 diabetes (p value: 0.05). Also aerobic training had a significant effect on serum glucose (P-value: 0.001) and insulin levels (P-value: 0.001).
Conclusion: It is concluded that aerobic training has significant effects on diabetic control by increasing the expression of PDX1 and GLUT-2 which lowers serum glucose.
Nader Moghaddam Dizaj Herik, Naimeh Moheb, Abdol Ali Banaeifar, Nasser Agha Mohammadzadeh,
Volume 13, Issue 1 (3-2021)
Abstract

Objective: The aim of the present study was to examine the effectiveness of Acceptance and Commitment Therapy (ACT) combined with aerobic exercise (AE) on anxiety symptoms, insulin resistance (IR) and lipid profile in women with T2DMmellitus (T2DM).
Materials and Methods: In the present study, 60 T2DM women with a mean age of 33.5 (± 3.52) years were selected from the patients who were referred to the specialized clinic Petroleum Industry in summer 2020. They were randomly divided into four groups of ACT (n=15), AE (n=15), ACT combined with AE (n=15), and the control group (n=15). Intervention programs were performed for 10 weeks, and then indices were collected before and after the intervention using blood tests and Beck Depression Inventory. Results: ACT led to a significant decrease in anxiety and LDL (P-value: 0.001). Moreover, AE significantly reduced the anxiety index and increased HDL (P-value: 0.001). In addition, the effect of ACT and exercise significantly reduced anxiety (P-value: 0.001) and LDL index (P-value: 0.03) and also increased HDL (P-value: 0.03). However, indices of blood glucose, insulin, insulin resistance, total cholesterol, and triglycerides did not indicate any significant changes in the intervention groups as compared with the control group (P-value<0.05).
Conclusion: According to the obtained findings, the use of psychological intervention along with AE could lead to a significant change in the symptoms of anxiety and some lipid indices in T2DM women. Also caused a non-significant improvement in glycemic index and can be regarded as a solution for diabetics
Parviz Shojaei, Mehran Ghahramani, Sirous Farsi,
Volume 13, Issue 4 (12-2021)
Abstract

Objective: Obesity is a chronic disease characterized by an excessive mass of adipose tissue in the body. The present study aimed to investigate the relationship between different genotypes of VEGF gene and changes in aerobic capacity following aerobic exercise in obese women. Materials and Methods: In this study, 23 inactive women aged 34 to 43 years with BMI 30 and 35 were purposefully selected and participated in eight weeks of aerobic exercise including 4 sessions per week and 30 minutes per session with an intensity of 55 to 75% of maximum heart rate. Before and after the training period, aerobic power (VO2max) was measured by the modified Bruce test. Saliva Sample was collected at 12 hours of fasting to measure VEGF genotypes. To compare aerobic capacity between different genotypes, since we had three genotypes GG, CG, and CC, one-way analysis of variance was used. Results: Although the mean amount of aerobic power changes of GG genotype was somewhat higher after eight weeks of aerobic training than the other two genotypes, this difference was not significant. (P-value= 0.663, P-value= 0.873 and P-value= 0.173, respectively). Conclusion: Eight weeks of aerobic training leads to increased aerobic capacity in obese women and increased VEGF plays a role, but there is not seemingly a difference between different VEGF genotypes for these changes. In any case, since this study was conducted for the first time, we need more studies to draw a more accurate conclusion.
Maryam Shirani Bidabadi, Jamshid Banaei Borojeni, Saeed Keshavarz, Mohammad Karimi,
Volume 13, Issue 4 (12-2021)
Abstract

Objective: This study aimed to evaluate the effect of consuming grape seed extract with moderate-intensity aerobic training on the expression of miR-126 and miR-29 in the cardiac tissue in type 1 diabetic male rats.
Materials and Methods: 40 rats with an initial weight range of 160-220 g were divided into five groups: Training + Extract, Training, Extract, Diabetic / Control, and Healthy / Control. Aerobic training program was moderate intensity and rats performed aerobic training for 60 minutes a day with the intensity 70 to 75% of maximum oxygen consumption (28 meters per minute). Grape seed extract was also administered by gavage at a dose of 40 mg/kg per day.
Results: Expression of both miRNAs in the three groups of training + extract, healthy training and control was significantly higher than the two groups of extract and diabetic control (P-value= 0.001). The difference between the three groups of training + extract, healthy training and control and also the difference between the two groups of extract and diabetic control were not significant (P-value> 0.05).
Conclusion: Aerobic training may be able to prevent cardiac disease caused by type 1 diabetes.

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