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Showing 3 results for Type 1 Diabetes

Zahra Razavi, Fariba Mohammadi,
Volume 4, Issue 2 (6-2012)

Objective: Limited joint mobility (LJM) has been described as the earliest clinical complication of diabetes mellitus. This study was performed to determine the frequency of limited joint mobility and to evaluate the association between LMJ and some chronic diabetic complications. Materials and Methods: A total of 125 patients with type 1 diabetes mellitus aged 11.89 ±3.75 years, with 4.2±2 years mean duration of disease were studied. Diabetic patients were compared with 125 healthy young controls that were group-matched for age and sex. Variables such as age, sex, duration of disease and mean HbA1c level were obtained from the patients′ medical records. LJM was assessed by observing the small joints of the hands in the prayer position. Student t-test and chi-square (X2) were used for comparisons between groups. Results: The frequency of LJM was significantly higher in diabetic patients compared to healthy controls (19.2% vs. 4%, p=0.001). Diabetic patients with LJM had not longer duration of diabetes than those without LJM (4.33 years compared to 4.08 years, p=0.55). Its presence was significantly related to microalbuminuria (p=0.017) and higher systolic blood pressure (p=0.001). Conclusion: Diabetic patients showed a significantly higher frequency of LJM than non-diabetic patients. LJM in the hands of patients with type 1 DM was associated with microalbuminuria but it was not related to retinopathy.
Javad Ramezani, , Mohammad Ali Azarbayjani, Maghsoud Peeri,
Volume 11, Issue 4 (12-2019)

Objective: Aerobic training and berberine chloride include antioxidant characteristics. In this study, aerobic training and berberine chloride intervention on the activity of antioxidant enzymes and lipid peroxidation of pancreatic tissue were investigated in type 1 diabetic male wistar rats.
Materials and Methods: In the current study, 56 Wistar male rats were randomly assigned to seven different groups (n= 8), these groups include healthy control, diabetic control, Berberine-treated diabetes (15&30 mg/kg), aerobic training-treated diabetes, Diabetes treated with Berberine and aerobic training (15&30 mg/kg). The aerobic training schedule consisted of 6 weeks treadmills with a frequency of 5 sessions per week. The Berberine was also fed a specific dose every day and a half before training. The superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were assessed using ELISA method.
Results: The results showed that aerobic training, as well as the intervention of Aerobic Training and Berberine chloride, had a significant effect on the increase of antioxidant enzymes SOD and CAT in the pancreatic tissue groups (P-value< 0.05), but did not significantly affect the GPX level (P-value> 0.05). There was a significant decrease in MDA level in all treatment groups (P-value< 0.05). In diabetic groups that received both treatments at the same time, the MDA level more decreased (P-value< 0.0005).
Conclusion: The aerobic training and berberine chloride concurrent intervention have a greater effect on the antioxidant enzymes in the pancreatic tissue of diabetic specimens. Therefore, it is recommended that aerobic training be done with berberine chloride.
Maryam Askari, Nasim Namiranian, Hassan Ali Mahmoudi Kohani, Seied Mohammad Reza Aghaee- Meybody, Saeed Hossein Khalilzade, Zohre Mozafari, Mahbubeh Shariati,
Volume 13, Issue 3 (9-2021)

Objective: The aim of this study was registration of type 1 diabetes mellitus (T1DM) in Yazd (the first phase of registration).
Materials and Methods: This study was a cross-sectional study on the first phase registration of T1DM in Yazd, Iran. Participants in this study included all patients diagnosed with T1DM by an endocrinologist. Data were analyzed by SPSS20 statistical software. Non-parametric tests were used in this study. Median ± Range was used to describe the data. Stata 13 software was used to calculate the confidence interval for the prevalence.
Results: Yazd T1DM registry (YT1DMR) was conducted from June 2018 to August 2020. All new and old cases of T1DM were registered. YT1DMR was able to identify 158 T1DM and it registered the data of 128 patients. The age of the participants was between 2.5 - 57 years old. Median ± Range of age in these participants was calculated 17 ± 54.5. In terms of gender, (57.81%, CI= 48.76-66.48) of these patients were male. The prevalence of overweight and obesity in these patients was 17.32 (CI= 11.18-25.04) and 6.29% (CI= 2.75-12.03), respectively.
Conclusion: In the future, all patients with T1DM in Yazd province are expected to enroll in the YT1DMR and be followed up.

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