Objective: Psoriasis is a chronic inflammatory disease. It may cause poor quality of life. The purpose of this study was to determine the prevalence of insulin resistance in patients with psoriasis to clarify the relationship between insulin resistance and psoriasis.

Materials and Methods: This case-control study was conducted on 110 patients with psoriasis and 110 healthy people. Fasting serum glucose and serum insulin levels were measured in both groups. The mean fasting serum glucose and serum insulin levels were measured in patients and controls and the prevalence of diabetes was calculated in both groups. Insulin resistance index was calculated with HOMA-IR formula.

Results: The mean fasting blood sugar was 106 mg/dl in patient group and 103.93 in the control group. The mean serum levels of insulin in the patient group was 10.27 (P-value: 0.679) and in the control group was 8.22 (P-value: 0.107). In psoriatic patients, 11 were diabetic (10%) and 13 (11.8%) in healthy group. Insulin resistance was found in 46.4% of patients (P-value: 0.665) and 39.1% of controls (P-value: 0.276).

Conclusion: According to the recent study there was no association between psoriasis and insulin resistance and also diabetes.