Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Thu, Apr 25, 2024
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Volume 11, Issue 4 (volume 11, number4 2019)
IJDO 2019, 11(4): 212-217 |
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Azizi R, Namiranian N, Jam Ashkezari S, Hassani Kaboutarkhani M, Gholami S, Davoudi Z et al . The Effects of Pioglitazone on Respiratory Function Test in Patients with Asthma and Type 2 Diabetes Mellitus- A before –after Study. IJDO 2019; 11 (4) :212-217
URL: http://ijdo.ssu.ac.ir/article-1-530-en.html
URL: http://ijdo.ssu.ac.ir/article-1-530-en.html
Reyhaneh Azizi 
, Nasim Namiranian , Saeedeh Jam Ashkezari , Miaad Hassani Kaboutarkhani , Somaye Gholami , Zahra Davoudi , Fatemeh Aghaei Meybodi *
, Nasim Namiranian , Saeedeh Jam Ashkezari , Miaad Hassani Kaboutarkhani , Somaye Gholami , Zahra Davoudi , Fatemeh Aghaei Meybodi *
Assistant Professor, Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract: (1473 Views)
Objective: Pioglitazone is one of the oral medications of type 2 diabetes (T2DM). The purpose of this study was to evaluate the effect of pioglitazone on asthma and diabetes treatment outcomes among patients with concurrent asthma and T2DM.
Materials and Methods: We conducted a quasi-experimental study on 11 patients with concurrent asthma and T2DM in Yazd Afshar Hospital and Yazd diabetic research center 2014-2017. The inclusion criteria were patients between 20-60 years old, at least one year with concurrent asthma and T2DM (documented with spirometer, bronchodilator test), ejection fraction more than 50%. Patients who were smoker, on oral corticosteroids, phenobarbital, methotrexate, rifampin, phenytoin and gemfibrozil were excluded. Laboratory tests (FBS, HbA1c, 2hpp, leptin), spirometer test, exhaled nitric oxide were done before and after 10 weeks of pioglitazone medication. All patients were visited every two weeks. The before and after pioglitazone treatment differences were checked by paired t-test and Wilcoxon Rank sum test.
Results: The mean (± SD) age of participants was 55.81 (±7.66). The median of differences of leptin (p-value: 0.885), FEV1 to FVC (P-value: 0.185), FEV1 (p-value: 0.386), NO (P-value: 0.574), FVC percent (P-value: 0.477), FEV1 percent (P-value: 0.515) did not differ before and after pioglitazone treatment.
Conclusion: Our finding suggested that pioglitazone may not be effective in the treatment and improvement of respiratory function in T2DM with concurrent asthma.
Materials and Methods: We conducted a quasi-experimental study on 11 patients with concurrent asthma and T2DM in Yazd Afshar Hospital and Yazd diabetic research center 2014-2017. The inclusion criteria were patients between 20-60 years old, at least one year with concurrent asthma and T2DM (documented with spirometer, bronchodilator test), ejection fraction more than 50%. Patients who were smoker, on oral corticosteroids, phenobarbital, methotrexate, rifampin, phenytoin and gemfibrozil were excluded. Laboratory tests (FBS, HbA1c, 2hpp, leptin), spirometer test, exhaled nitric oxide were done before and after 10 weeks of pioglitazone medication. All patients were visited every two weeks. The before and after pioglitazone treatment differences were checked by paired t-test and Wilcoxon Rank sum test.
Results: The mean (± SD) age of participants was 55.81 (±7.66). The median of differences of leptin (p-value: 0.885), FEV1 to FVC (P-value: 0.185), FEV1 (p-value: 0.386), NO (P-value: 0.574), FVC percent (P-value: 0.477), FEV1 percent (P-value: 0.515) did not differ before and after pioglitazone treatment.
Conclusion: Our finding suggested that pioglitazone may not be effective in the treatment and improvement of respiratory function in T2DM with concurrent asthma.
Type of Study: Research |
Subject:
Special
Received: 2020/05/21 | Accepted: 2020/05/21 | Published: 2020/05/21
Received: 2020/05/21 | Accepted: 2020/05/21 | Published: 2020/05/21
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