Iranian Journal of Diabetes and Obesity
Shahid Sadoughi University Of Medical Sciences
Thu, Apr 25, 2024
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Volume 12, Issue 1 (volume 12, number 1 2020)
IJDO 2020, 12(1): 7-13 |
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Shahsavar A, Rajabi H, Gharakhanlou R, Dehkhoda M R. Effect of Aerobic Training and L-carnitine on MDA, GPX and Hippocampal Neurogenesis in Diabetic Rats. IJDO 2020; 12 (1) :7-13
URL: http://ijdo.ssu.ac.ir/article-1-542-en.html
URL: http://ijdo.ssu.ac.ir/article-1-542-en.html
Effect of Aerobic Training and L-carnitine on MDA, GPX and Hippocampal Neurogenesis in Diabetic Rats
PhD Student of Exercise Physiology, Kharazmi University, Tehran, Iran.
Abstract: (1622 Views)
Objective: L-carnitine is associated with an increase in antioxidant enzymes activities and reduction in oxidative damage. The aim of this study was to evaluate the effect of aerobic training and L-carnitine cconsumption on hippocampal oxidative stress and neurogenesis factors in diabetic rats.
Materials and Methods: In this experimental study, 45 male wistar rats were divided into six groups including sham (5 rats), healthy control (8 rats), diabetic control (8 rats), diabetic receiving L-carnitine (8 rats), diabetic receiving aerobic exercise (8 rats), diabetic receiving L-carnitine and aerobic exercise (8 rats). Rats with serum glucose level higher than 300 mg/dL were considered diabetic. L-carnitine supplemented dose was 100 mg per day. The aerobic exercise protocol including five sessions per week started at a speed of 10 for 20 min at a zero-degree grade in the first week and gradually reached a speed of 20 for 40 min at a grade of 5 in the sixth week. The Hippocampal tissues of the dependent variables (BDNF, MDA and GPX) were measured by ELISA 24 hours after the last session of the exercise program. One-way ANOVA and Tukey's post hoc test at P-value< 0.05 were used to analyze the data.
Results: The results of the study revealed that aerobic exercise and L-carnitine consumption have a significant effect on BDNF (P-value= 001), MDA (P-value= 001) and GPX (P-value= 001) of the diabetic rats.
Conclusion: According to the results, it is suggested that diabetic patients use aerobic exercise and supplementation with carnitine with caution and physician advice.
Materials and Methods: In this experimental study, 45 male wistar rats were divided into six groups including sham (5 rats), healthy control (8 rats), diabetic control (8 rats), diabetic receiving L-carnitine (8 rats), diabetic receiving aerobic exercise (8 rats), diabetic receiving L-carnitine and aerobic exercise (8 rats). Rats with serum glucose level higher than 300 mg/dL were considered diabetic. L-carnitine supplemented dose was 100 mg per day. The aerobic exercise protocol including five sessions per week started at a speed of 10 for 20 min at a zero-degree grade in the first week and gradually reached a speed of 20 for 40 min at a grade of 5 in the sixth week. The Hippocampal tissues of the dependent variables (BDNF, MDA and GPX) were measured by ELISA 24 hours after the last session of the exercise program. One-way ANOVA and Tukey's post hoc test at P-value< 0.05 were used to analyze the data.
Results: The results of the study revealed that aerobic exercise and L-carnitine consumption have a significant effect on BDNF (P-value= 001), MDA (P-value= 001) and GPX (P-value= 001) of the diabetic rats.
Conclusion: According to the results, it is suggested that diabetic patients use aerobic exercise and supplementation with carnitine with caution and physician advice.
Type of Study: Research |
Subject:
Special
Received: 2020/07/2 | Accepted: 2020/07/2 | Published: 2020/07/2
Received: 2020/07/2 | Accepted: 2020/07/2 | Published: 2020/07/2
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