Volume 13, Issue 2 (volume 13, number 2 2021)                   IJDO 2021, 13(2): 113-116 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Dehghan M, Akhoundimeybodi Z. Insulin Edema in Type 2 Diabetes Mellitus: A Case Report Study. IJDO 2021; 13 (2) :113-116
URL: http://ijdo.ssu.ac.ir/article-1-634-en.html
Assistant Professor at Departments of Internal Medical at Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract:   (695 Views)
Edema is a rare complication induced by insulin therapy, which is mostly developed after initiation or intensification of insulin treatment in diabetic patients. Edema can either be localized or generalized. Our patient was a 34-year-old woman with type 2 diabetes. She was under treatment with oral agents medication, but recently insulin therapy was initiated for her due to inability to control her hyperglycemia and development of diabetic ketoacidosis. The patient referred while suffering from bilateral lower extremity edema. During follow-up, her edema resolved spontaneously without any specific treatments. In this patient, the diagnosis of edema was based on ruling out other causes, along with more accurate blood glucose control during diabetic ketoacidosis process and spontaneous recovery. Based on our finding, it can be concluded that insulin-induced edema is not a worrisome problem and in most cases, its symptoms resolve without treatment and through restricting the consumption of water and salt.
Full-Text [PDF 84 kb]   (452 Downloads)    
Type of Study: Research | Subject: Special
Received: 2021/06/16 | Accepted: 2021/06/20 | Published: 2021/06/20

1. Wong M, Balakrishnan T. Anasarca in newly diagnosed type 1 diabetes: review of the pathophysiology of insulin edema. Cureus. 2020;12(3). [DOI:10.7759/cureus.7234]
2. Bulus AD, Andiran N, Köksal AO. Insulin edema in type 1 diabetes mellitus: report of a case and brief review of the literature. Iranian journal of pediatrics. 2016;26(4). [DOI:10.5812/ijp.5077]
3. Tufton N, Coppack S, Huda B. An unusual cause of generalized insulin edema and truncal neuropathy. Journal of Medical Cases. 2015;6(12):563-5. [DOI:10.14740/jmc2345w]
4. Kalambokis GN, Tsatsoulis AA, Tsianos EV. The edematogenic properties of insulin. American journal of kidney diseases. 2004;44(4):575-90. [DOI:10.1016/S0272-6386(04)00960-6]
5. Onyiriuka AN, Ehirim FA. Insulin-induced oedema in a patient with diabetes mellitus complicated by ketoacidosis. Acta Medica Indonesiana. 2014;46(4).
6. Mamoulakis D, Bitsori M, Galanakis E, Raissaki M, Kalmanti M. Insulin‐induced oedema in children and adolescents. Journal of paediatrics and child health. 2006;42(10):655-7. [DOI:10.1111/j.1440-1754.2006.00911.x]
7. Chelliah A, Burge MR. Insulin edema in the twenty-first century: review of the existing literature. Journal of investigative medicine. 2004;52(2):104-8. https://doi.org/10.1097/00042871-200403000-00018 https://doi.org/10.2310/6650.2004.17824 [DOI:10.1136/jim-52-02-18]
8. Bas VN, Cetinkaya S, Agladıoglu SY, Kendirici HN, Bilgili H, Yildirim N, et al. Insulin oedema in newly diagnosed type 1 diabetes mellitus. Journal of clinical research in pediatric endocrinology. 2010;2(1):46. [DOI:10.4274/jcrpe.v2i1.46]
9. Kan Y, Anno T, Kawasaki F, Takai M, Shigemoto R, Kaneto H, et al. Bilateral lower limb edema induced by rapid improvement of glycemic control with insulin therapy in a subject with poorly controlled type 2 diabetes. Acta diabetologica. 2017;54(6):611-3. [DOI:10.1007/s00592-017-0997-7]
10. Bulus AD, Andiran N, Köksal AO. Insulin edema in type 1 diabetes mellitus: report of a case and brief review of the literature. Iranian journal of pediatrics. 2016;26(4). [DOI:10.5812/ijp.5077]
11. Kalambokis G, Tsatsoulis A, Economou G, Tsianos EV. A case of insulin edema with inappropriate hyperaldosteronism. Journal of endocrinological investigation. 2004;27(10):957-60. [DOI:10.1007/BF03347540]

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Iranian Journal of Diabetes and Obesity

Designed & Developed by : Yektaweb