Volume 14, Issue 4 (volume 14, number 4 2022)                   IJDO 2022, 14(4): 240-247 | Back to browse issues page

XML Print

Associate Professor, Department of Food Sciences and Technology, University of Mohaghegh Ardabili, Ardabil, Iran.
Abstract:   (330 Views)
Objective: Diabetes mellitus (DM) is recognized as one of the most critical health issues and leading causes of death worldwide. This disease is associated with macro-vascular and micro-vascular complications. The prevention of DM and its complications is always essential. In recent years, due to the known biological properties of some foods, the tendency to consume these foods has increased. This narrative review showed the effect of cinnamon, ginseng, thyme, sesame oil, fenugreek, saffron, aloe vera, garlic, ginger, turmeric, and green tea on improving insulin sensitivity, reducing blood sugar, blood lipid, and blood pressure, and regulating metabolism. Therefore, it is suggested that these nutraceuticals could be considered in the special food formulation of diabetic patients. It seems that the anti-diabetic properties of nutraceutical interest of diabetic persons specify their potential role in improving insulin sensitivity, lowering blood sugar, blood lipid, and blood pressure, and regulating metabolism.
Full-Text [PDF 206 kb]   (125 Downloads)    
Type of Study: Research | Subject: Special
Received: 2022/06/18 | Accepted: 2022/09/22 | Published: 2022/11/19

1. International Diabetes Federation. IDF Diabetes Atlas, 10th ed. Brussels, Belgium: 2021. Available at: https://www.diabetesatlas.org.
2. Papatheodorou K, Banach M, Bekiari E, Rizzo M, Edmonds M. Complications of diabetes 2017. Journal of diabetes research. 2018;2018. [DOI:10.1155/2018/3086167]
3. Venkatakrishnan K, Chiu HF, Wang CK. Popular functional foods and herbs for the management of type-2-diabetes mellitus: a comprehensive review with special reference to clinical trials and its proposed mechanism. Journal of Functional Foods. 2019;57:425-38. [DOI:10.1016/j.jff.2019.04.039]
4. Tuttolomondo A, Maida C, Pinto A. Diabetic foot syndrome as a possible cardiovascular marker in diabetic patients. Journal of diabetes research. 2015;2015. [DOI:10.1155/2015/268390]
5. Hasanpour M, Iranshahy M, Iranshahi M. The application of metabolomics in investigating anti-diabetic activity of medicinal plants. Biomedicine & Pharmacotherapy. 2020 ;128:110263. [DOI:10.1016/j.biopha.2020.110263]
6. Ansari P, Hannon-Fletcher MP, Flatt PR, Abdel-Wahab YH. Effects of 22 traditional anti-diabetic medicinal plants on DPP-IV enzyme activity and glucose homeostasis in high-fat fed obese diabetic rats. Bioscience Reports. 2021;41(1). [DOI:10.1042/BSR20203824]
7. Patil SP, Goswami A, Kalia K, Kate AS. Plant-derived bioactive peptides: A treatment to cure diabetes. International Journal of Peptide Research and Therapeutics. 2020;26(2):955-68. [DOI:10.1007/s10989-019-09899-z]
8. Matalqah SM, Al-Tawalbeh DM. Medicinal plants potential against diabetes mellitus. diabetes. 2025;9(10):11.
9. Egbuna C, Dable-Tupas G. Functional foods and nutraceuticals. Springer Nature Switzerland AG. 2020;1:1-632. [DOI:10.1007/978-3-030-42319-3]
10. Sharma S, Mandal A, Kant R, Jachak S, Jagzape M. Is cinnamon efficacious for glycaemic control in type-2 diabetes mellitus?. diabetes. 2020;30:32.
11. Kawatra P, Rajagopalan R. Cinnamon: Mystic powers of a minute ingredient. Pharmacognosy research. 2015;7(Suppl 1):S1. [DOI:10.4103/0974-8490.157990]
12. Ghaffari S, Roshanravan N. The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature. Food Research International. 2020;128:108749. [DOI:10.1016/j.foodres.2019.108749]
13. Tulini FL, Souza VB, Echalar-Barrientos MA, Thomazini M, Pallone EM, Favaro-Trindade CS. Development of solid lipid microparticles loaded with a proanthocyanidin-rich cinnamon extract (Cinnamomum zeylanicum): Potential for increasing antioxidant content in functional foods for diabetic population. Food Research International. 2016;85:10-8. [DOI:10.1016/j.foodres.2016.04.006]
14. Zare R, Nadjarzadeh A, Zarshenas MM, Shams M, Heydari M. Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial. Clinical nutrition. 2019;38(2):549-56. [DOI:10.1016/j.clnu.2018.03.003]
15. Governa P, Baini G, Borgonetti V, Cettolin G, Giachetti D, Magnano AR, et al. Phytotherapy in the management of diabetes: a review. Molecules. 2018;23(1):105. [DOI:10.3390/molecules23010105]
16. Anderson RA, Zhan Z, Luo R, Guo X, Guo Q, Zhou J, et al. Cinnamon extract lowers glucose, insulin and cholesterol in people with elevated serum glucose. Journal of traditional and complementary medicine. 2016;6(4):332-6. [DOI:10.1016/j.jtcme.2015.03.005]
17. Qin B, Panickar KS, Anderson RA. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. Journal of diabetes science and technology. 2010;4(3):685-93. [DOI:10.1177/193229681000400324]
18. Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutrition Research. 2012; 32(6):408-12. [DOI:10.1016/j.nutres.2012.05.003]
19. Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI. Effect of cinnamon on glucose control and lipid parameters. Diabetes care. 2008;31(1):41-3. [DOI:10.2337/dc07-1711]
20. Bandara T, Uluwaduge I, Jansz ER. Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. International journal of food sciences and nutrition. 2012 ;63(3):380-6. [DOI:10.3109/09637486.2011.627849]
21. Cho EG, Choi SY, Kim H, Choi EJ, Lee EJ, Park PJ, et al. Panax ginseng-derived extracellular vesicles facilitate anti-senescence effects in human skin cells: an eco-friendly and sustainable way to use ginseng substances. Cells. 2021;10(3):486. [DOI:10.3390/cells10030486]
22. Nuri TH, Yee JC, Gupta M, Khan MA, Ming LC. A review of Panax ginseng as an herbal medicine. Archives of Pharmacy Practice. 2016;7(5):61-5. [DOI:10.4103/2045-080X.183030]
23. Bang H, Kwak JH, Ahn HY, Shin DY, Lee JH. Korean red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2 diabetes mellitus. Journal of medicinal food. 2014;17(1):128-34. [DOI:10.1089/jmf.2013.2889]
24. Gui QF, Xu ZR, Xu KY, Yang YM. The efficacy of ginseng-related therapies in type 2 diabetes mellitus: an updated systematic review and meta-analysis. Medicine. 2016;95(6). [DOI:10.1097/MD.0000000000002584]
25. Vuksan V, Xu ZZ, Jovanovski E, Jenkins AL, Beljan-Zdravkovic U, Sievenpiper JL, et al. Efficacy and safety of American ginseng (Panax quinquefolius L.) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: a double-blind, randomized, cross-over clinical trial. European journal of nutrition. 2019;58(3):1237-45. [DOI:10.1007/s00394-018-1642-0]
26. Li KK, Gong XJ. A review on the medicinal potential of Panax ginseng saponins in diabetes mellitus. Rsc Advances. 2015;5(59):47353-66. [DOI:10.1039/C5RA05864C]
27. Asghari B, Habibzadeh F, Ghorbani Nohooji M. Persian Thyme (Thymus persicus): a plant containing active metabolites with antioxidant, anti-diabetic and anti-Alzheimer effects. Journal of Medicinal Plants. 2019;18(70):97-109.(in Persian) [DOI:10.29252/jmp.2.70.97]
28. Leal F, Taghouti M, Nunes F, Silva A, Coelho AC, Matos M. Thymus Plants: A review-Micropropagation, molecular and antifungal activity. Active ingredients from aromatic and medicinal plants. 2017:107-26. [DOI:10.5772/66623]
29. Zamani N, Shams M, Nimrouzi M, Zarshenas MM, Foroughi AA, Abarghooei EF, et al. The effects of Zataria multiflora Boiss.(Shirazi thyme) on nonalcoholic fatty liver disease and insulin resistance: A randomized double-blind placebo-controlled clinical trial. Complementary therapies in medicine. 2018;41:118-23. [DOI:10.1016/j.ctim.2018.09.010]
30. Mohammadi A, Gholamhoseinian A, Fallah H. Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats. Iranian journal of basic medical sciences. 2014;17(4):263.
31. Maideen NM, Balasubramaniam R. Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs. Journal of Herbmed Pharmacology. 2018;7(3). [DOI:10.15171/jhp.2018.32]
32. Haidari F, Mohammadshahi M, Zarei M, Gorji Z. Effects of sesame butter (Ardeh) versus sesame oil on metabolic and oxidative stress markers in streptozotocin-induced diabetic rats. Iranian journal of medical sciences. 2016;41(2):102.
33. Houston MC. Treatment of hypertension with nutrition and nutraceutical supplements: Part 2. Alternative and Complementary Therapies. 2019;25(1):23-36. [DOI:10.1089/act.2018.29197.mho]
34. Sankar D, Ali A, Sambandam G, Rao R. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. Clinical Nutrition. 2011;30(3):351-8. [DOI:10.1016/j.clnu.2010.11.005]
35. Goyal S, Gupta N, Chatterjee S. Investigating therapeutic potential of Trigonella foenum-graecum L. as our defense mechanism against several human diseases. Journal of toxicology. 2016;2016. [DOI:10.1155/2016/1250387]
36. Verma N, Usman K, Patel N, Jain A, Dhakre S, Swaroop A, et al. A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes. Food & Nutrition Research. 2016;60(1):32382. [DOI:10.3402/fnr.v60.32382]
37. Geberemeskel GA, Debebe YG, Nguse NA. Antidiabetic effect of fenugreek seed powder solution (Trigonella foenum-graecum L.) on hyperlipidemia in diabetic patients. Journal of diabetes research. 2019;2019. [DOI:10.1155/2019/8507453]
38. Khorasanchi Z, Shafiee M, Kermanshahi F, Khazaei M, Ryzhikov M, Parizadeh MR, et al. Crocus sativus a natural food coloring and flavoring has potent anti-tumor properties. Phytomedicine. 2018;43:21-7. [DOI:10.1016/j.phymed.2018.03.041]
39. Mobasseri M, Ostadrahimi A, Tajaddini A, Asghari S, Barati M, Akbarzadeh M, et al. Effects of saffron supplementation on glycemia and inflammation in patients with type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical trial study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(4):527-34. [DOI:10.1016/j.dsx.2020.04.031]
40. Tahereh F, Saeed S. The effect of saffron (Crocus sativus L.) and its ingredients on the management of diabetes mellitus and dislipidemia. African Journal of Pharmacy and Pharmacology. 2014;8(20):541-9. [DOI:10.5897/AJPPX2013.0006]
41. Milajerdi A, Jazayeri S, Hashemzadeh N, Shirzadi E, Derakhshan Z, Djazayeri A, et al. The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2018;23. [DOI:10.4103/jrms.JRMS_286_17]
42. Sharma R, Amin H, Prajapati PK. Plant kingdom Nutraceuticals for diabetes. Journal of Ayurvedic and Herbal Medicine. 2016;2(6):224-8. [DOI:10.31254/jahm.2016.2607]
43. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine. 1996;3(3):245-8. [DOI:10.1016/S0944-7113(96)80061-4]
44. Kaur N, Fernandez R, Sim J. Effect of Aloe vera on glycemic outcomes in patients with diabetes mellitus: a systematic review protocol. JBI Evidence Synthesis. 2017;15(9):2300-6. [DOI:10.11124/JBISRIR-2016-002958]
45. Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. Journal of diabetes & metabolic disorders. 2015;14(1):1-7. [DOI:10.1186/s40200-015-0137-2]
46. Gupta R, Bajpai KG, Johri S, Saxena AM. An overview of Indian novel traditional medicinal plants with anti-diabetic potentials. African Journal of Traditional, Complementary and Alternative Medicines. 2008;5(1):1-7.
47. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clinical and experimental pharmacology and physiology. 2006;33(3):232-7. [DOI:10.1111/j.1440-1681.2006.04351.x]
48. Alves QL, Camargo SB, Silva DF. Role of nutraceuticals in the prevention and treatment of hypertension and cardiovascular diseases. Journal of Hypertension and Management. 2019;5(1):1-10. [DOI:10.23937/2474-3690/1510037]
49. Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, et al. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. Journal of traditional and complementary medicine. 2018;8(3):361-76. [DOI:10.1016/j.jtcme.2017.08.012]
50. Rizwan AM, Rafeeq AK, Imran A. Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus. Journal of Medicinal Plants Research. 2011;5(13):2922-8.
51. Wang J, Zhang X, Lan H, Wang W. Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials. Food & nutrition research. 2017;61(1):1377571. [DOI:10.1080/16546628.2017.1377571]
52. Ballali S, Lanciai F. Functional food and diabetes: a natural way in diabetes prevention?. International journal of food sciences and nutrition. 2012;63(sup1):51-61. [DOI:10.3109/09637486.2011.637487]
53. Haniadka R, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food & function. 2013;4(6):845-55. [DOI:10.1039/c3fo30337c]
54. Wang J, Ke W, Bao R, Hu X, Chen F. Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review. Annals of the New York academy of sciences. 2017;1398(1):83-98. [DOI:10.1111/nyas.13375]
55. Lindstedt I. Ginger and diabetes: A mini-review. Archives of General Internal Medicine. 2018;2(2):29-33.
56. Jafarnejad S, Keshavarz SA, Mahbubi S, Saremi S, Arab A, Abbasi S, et al. Effect of ginger (Zingiber officinale) on blood glucose and lipid concentrations in diabetic and hyperlipidemic subjects: A meta-analysis of randomized controlled trials. Journal of functional foods. 2017;29:127-34. [DOI:10.1016/j.jff.2016.12.006]
57. Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. Journal of complementary and integrative medicine. 2015;12(2):165-70. [DOI:10.1515/jcim-2014-0021]
58. Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives-A review. Journal of traditional and complementary medicine. 2017;7(2):205-33. [DOI:10.1016/j.jtcme.2016.05.005]
59. Ghorbani Z, Hekmatdoost A, Mirmiran P. Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. International journal of endocrinology and metabolism. 2014;12(4). [DOI:10.5812/ijem.18081]
60. Lekshmi PC, Arimboor R, Indulekha PS, Nirmala Menon A. Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. International journal of food sciences and nutrition. 2012;63(7):832-4. [DOI:10.3109/09637486.2011.607156]
61. Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Mobarhan MG, et al. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial. Avicenna journal of phytomedicine. 2016;6(5):567.
62. De Melo IS, Dos Santos AF, Bueno NB. Curcumin or combined curcuminoids are effective in lowering the fasting blood glucose concentrations of individuals with dysglycemia: systematic review and meta-analysis of randomized controlled trials. Pharmacological research. 2018 ;128:137-44. [DOI:10.1016/j.phrs.2017.09.010]
63. Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutrition research. 2012;32(6):421-7. [DOI:10.1016/j.nutres.2012.05.007]
64. Alkhatib A, Tsang C, Tiss A, Bahorun T, Arefanian H, Barake R, et al. Functional foods and lifestyle approaches for diabetes prevention and management. Nutrients. 2017;9(12):1310. [DOI:10.3390/nu9121310]
65. Liu CY, Huang CJ, Huang LH, Chen IJ, Chiu JP, Hsu CH. Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial. PLoS One. 2014 ;9(3):e91163. [DOI:10.1371/journal.pone.0091163]
66. Fu QY, Li QS, Lin XM, Qiao RY, Yang R, Li XM, et al. Antidiabetic effects of tea. Molecules. 2017;22(5):849. [DOI:10.3390/molecules22050849]

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.