Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise and Consumption of Cinnamon on Meteorin-like protein (METRNL) and Irisin in Diabetic Women

Ghasemi, Mahdieh; Abdi, Ahmad; Barari, Alireza; Jalali Dehkordi, Khosrow

doi:10.18502/ijdo.v17i2.18850

Volume 17, Issue 2 (5-2025) IJDO 2025, 17(2): 119-129 | Back to browse issues page

‎ 10.18502/ijdo.v17i2.18850

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Ghasemi M, Abdi A, Barari A, Jalali Dehkordi K. Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise and Consumption of Cinnamon on Meteorin-like protein (METRNL) and Irisin in Diabetic Women. IJDO 2025; 17 (2) :119-129
URL: http://ijdo.ssu.ac.ir/article-1-954-en.html

Effect of Different Intensities of Aerobic Exercise Combined with Resistance Exercise and Consumption of Cinnamon on Meteorin-like protein (METRNL) and Irisin in Diabetic Women

Mahdieh Ghasemi

, Ahmad Abdi ^*

, Alireza Barari

, Khosrow Jalali Dehkordi

Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.

Abstract: (29 Views)

Objective: Studies show that exercise and herbal supplements help improves type 2 diabetes. The aim of this study was to investigate the effect of different intensities aerobic exercise with resistance training and cinnamon on the levels of METRNL and irisin in diabetic women.
Materials and Methods: In this clinical trial study, 54 diabetic women (age 41.73± 4.05) were selected from Nowshahr and randomly allocated into six groups; Control (C), Resistance and Moderate Aerobic Exercise (RME, 50% VO2max, 200 kcal), Resistance and Vigorous Aerobic Exercise (RVE, 80% VO2max, 200 kcal), Cinnamon (Ci, 1000 mg/day), Resistance and Moderate Aerobic Exercise+Cinnamon (RMECi), Resistance and Vigorous Aerobic Exercise+Cinnamon (RVECi). Data were analyzed using an independent t-test and ANCOVA (P< 0.05).
Results: It was observed a significant increase in Metrnl, irisin in the RME (P= 0.041 and P= 0.004, respectively), RVE (P= 0.0001 and P= 0.0001, respectively), Ci (P= 0.006 and P= 0.0001, respectively), RMECi (P= 0.00 and P= 0.0001, respectively) and RVECi (P= 0.001 and P= 0.0001, respectively) compared to group C. The increase in Metrnl and irisin was significant in RVE compared to RME (P= 0.045, and P= 0.028, respectively); RMECi relative to RME (P= 0.004) and Ci (P= 0.0001); RVECi compared to RME (P= 0.0001), RVE and Ci (P= 0.0001). It was also observed a significant decrease in HOMA-IR in the RME (P= 0.014), RVE (P= 0.001), Ci (P= 0.044), RMECi (P= 0.0001), and RVECi (P= 0.0001) compared to group C.
Conclusion: Combining exercise with cinnamon may help prevent or delay T2D complications. RVE exercise showed greater improvements in irisin and HOMA-IR than RME.

Keywords: Cinnamomum, Diabetes mellitus, Exercise, FNDC5 protein, Irisin, Metrnl protein

Full-Text [PDF 689 kb] (11 Downloads)

Type of Study: Research | Subject: Special
Received: 2024/09/21 | Accepted: 2025/04/27 | Published: 2025/05/31

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