Showing 8 results for Parsaeyan
Nayereh Parsaeyan, Bemanali Jalali-Khanabadi,
Volume 3, Issue 1 (4-2011)
Abstract
OBJECTIVE: The aim of this study was to evaluate the effect of good glycemic control on serum lipids levels and lipid peroxidation, and to find out the relationship between the level of malondialdehyde and HbA1c in type 2 diabetes.
MATERIALS AND METHODS: Fifty type 2 diabetic patients aged 40-60 years with the history of diabetes for more than 10 years were studied. Glycemic control was stable for six months which included: having a healthy diet, doing adequate levels of daily exercise, using medicine for diabetes control, control and measuring blood glucose more often. HbA1c, fasting blood glucose, serum levels of lipids, lipoproteins and oxidation parameter (malondialdehyde level) are measured at the base line and after 6 months good glycemic control.
RESULTS: Good glycemic control decreased fasting blood sugar (FBS), HbA1c, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and malondialdehyde. However, the level of high density lipoprotein cholesterol (HDL-C) increased. There was no significant relationship between malondialdehyde and HbA1cin type 2 diabetes.
CONCLUSION: These results demonstrated that glycemic control in type 2 diabetic patients, in addition to beneficial effects on lipid profiles, may contribute in lowering lipid peroxidation parameter (malondialdehyde).
Nayereh Parsaeyan, Hassan Mozaffari–khosravi , Mohammad Reza Mozayan,
Volume 4, Issue 1 (5-2012)
Abstract
OBJECTIVE: The aim of this study was to investigate the effect of pomegranate juice (PJ) on the paraoxonase and arylesterase activity of human serum paraoxonase( PON1).
MATERIAL AND METHOD: Fifty patients with type 2 diabetes mellitus consumed 200 ml of PJ daily for a period of 6 weeks. Blood was collected from the patients before and after PJ consumption after 12 h of fasting. Blood sugar, total cholesterol, triglyceride, and HDL-C were measured by enzymatic kit method and autoanalyzer. The concentration of LDL-C was calculated by using Friedwald formula. The malondialdehyde concentration (μmol/L) was determined by thiobarbituric acid (TBA) assay. Paraoxonase and arylesterase activity of PON1 enzyme were measured using paraoxone and phenylacetate as the substrates.
RESULTS: The concentration of fasting blood sugar, total cholesterol, LDL-C and malondialdehyde significantly (p<0.001) decreased after the intervention. Paraoxonase and arylesterase activity of PON1 significantly (p<0.001) increased after the intervention. However, there were no significant changes in serum triglyceride and HDL-C. There was a significant positive correlation between paraoxonase and arylesterase activity of PON1 and serum HDL-C concentration. A significant negative correlation was detected between paraoxonase and arylesterase activity of PON1 and FBS.
CONCLUSION: It can be concluded that PJ consumption as an antioxidant may have a contribution in changing fasting blood sugar, lipid profiles, lipoprotein oxidation, and PON1 activity.
Nayereh Parsaeyan,
Volume 4, Issue 2 (6-2012)
Abstract
Objective: The purpose of this study was to investigate the effect of coriander seed powder (CSP) on the atherosclerotic and cardioprotective indices in type 2 diabetic patients.
Materials and Methods: In this study, fifty type 2 diabetic patients consumed 2 capsules of the CSP /day for a period of 6weeks. Blood samples were collected from the patients before and after the course of CSP consumption after 12 h of fasting .The plasma glucose, total cholesterol, triglyceride, LDL-C , HDL-C ,urea and creatinine were measured before and after the CSP consumption for 6 weeks. Atherosclerotic and cardioprotective indices were calculated.
Results: The CSP consumption for 6 weeks in type 2 diabetic patients significantly reduced plasma glucose, total cholesterol, triglyceride, and LDL-C (p< 0.001), but HDL-C was not significantly changed (p≥ 0.05).But there was no significant effect on urea and creatinine concentrations. Atherosclerotic index decreased while cardioprotective indices increased.
Conclusion: Since the CSP consumption reduced several components of metabolic syndrome and decreased atherosclerotic and increased cardioprotective indices, the CSP may have cardiovascular protective effect in type 2 diabetic patients.
Nayereh Parsaeyan, Hassan Mozaffari–khosravi,
Volume 4, Issue 4 (10-2012)
Abstract
Objective: Type 2 diabetes mellitus is a complex metabolic disorder with adverse cardiovascular risk. Chromium (Cr) is an essential nutrient and its role in carbohydrate and lipid metabolism has not been clarified especially in Iran. The aim of this study was to evaluate the effect of chromium picolinate administration on blood glucose, HbA1c, lipid profile and lipid peroxidation in type 2 diabetic patients.
Materials and Methods: One-hundred subjects were studied in double-blinded and placebo-controlled. They divided into study and placebo groups by simple randomization. The study group received 200µg chromium picolinate capsule twice daily and the placebo group received capsule devoid of chromium (from Century Company) for 12 weeks. Subjects were instructed not to change their normal eating and living habits and medication. Fasting blood glucose, HbA1c, lipid profile and malondialdehyde were measured and analyzed at beginning and completion of the study.
Results: Results revealed that chromium picolinate consumption in type 2 diabetic patients reduced fasting blood glucose (48.83%, p≤ 0.01), HbA1c (22%, p<0.001), total cholesterol (6.17%, p≤ 0.02), triglyceride (11.36%, p < 0. 5), LDL (17.22%, p< 0.05), HDL (5.78%, p< 0.05) and malondialdehyde (11.37).
Conclusion: These data demonstrate beneficial effect of chromium picolinate supplementation on blood glucose, HbA1c, lipid profile and lipids peroxidation in type 2 diabetic patients.
Nayereh Parsaeyan, Mohamad Ebrahim Rezvani,
Volume 6, Issue 4 (12-2014)
Abstract
Objective: The effect of herbal medicine is more useful than synthetic medicines. The present research paper aims to show the effects of leaves extracts of Zizyphus Spina Christi (ZSC) on lipid profile, lipid peroxidation and activities of aminotransferase enzymes in streptozocin induced diabetic adult male rats.
Materials and Methods: Fifty six male rats weighing 150-200 gm were included in this study. They were divided into 8 groups. The first group, non-diabetic control rats received distilled water. The second, third and fourth groups, non-diabetic rats were given doses 50 mg/kg body weight (BW), 75 mg/kg (BW) and 100mg/kg (BW) ZSC extracts. The fifth group, diabetic control, received distilled water. The sixth, seventh and eighth were given doses, 50mg/kg (BW), 75 mg/kg (BW) and 100mg/kg (BW) ZSC extracts. Weight and fasting blood glucose were measured every week and the period of treatment continued for four weeks. Serum lipid profile, malondialdehyde (MDA) and aminotransferase enzymes (AST, ALT) were measured at the end of experiment.
Results: In diabetic rats ZSC leaves extract significantly reduced serum total cholesterol, triglyceride, LDL-C, AST (aspartate aminotransferase) and ALT (alanine aminotranferase) (P<0.05). The serum malondialdehyde markedly decreased (P<0.001), But HDL –C increased significantly (P<0.05).
Conclusion: The present paper revealed that ZCS leaves extract has beneficial effects on lipid profile, lipid peroxidation and aminotranferase enzymes in diabetic rats.
Nayereh Parsaeyan,
Volume 7, Issue 2 (6-2015)
Abstract
Objective: DM is a major medical problem in developing countries such as Iran. Blood sugar and lipids levels increase in diabetics exacerbates the onset of diabetes mellitus (DM) late complications. Researchers have focused on herbal medicines improve sugar and lipid levels against side decreasing effects and possible inefficacy of chemical drugs. This study has assessed the effect of curcumin on fructosamine, lipids profile and lipid peroxidation in patients with type 2 DM.
Materials and Methods: Sixty type II diabetics (40-60 years old) with history of diabetes above 10 years who had referred to diabetes center of Shahid Sadoughi medical university, were randomly divided in to two groups of case and control. The case group daily received two capsules of 250mg curcumin for 6 weeks and the control group took placebo over the trialperiod. Blood samples were collected in both groups at the beginning and end of the experiment .The cholesterol, Triglyceride, Low and high density lipoprotein were measured by auto analyzer (Auto lab). The rest of serums were frozen for measuring fructosamine and malondialdehyde by nitroblue tetrazolium and thiobarbituric acid tests in same condition. These tests were repeated after six weeks. Statistic alanalysis was done by SPSS 15, paired and independent T-tests.
Results Finally, 48 participants completed the study. After 6 weeks, the case group showed significant decrease in fructosamine, cholesterol, triglyceride, LDL-cholesterol, malondialdehyde and increase in HDL-cholesterol (P=0.001) .At the end of study significant differences were observed between the meansfructosamine (P=0.023) and HDL-cholesterol (P=0.013) in two groups of case and control. No significant changes were observed for mean cholesterol, triglyceride, LDL-cholesterol and malondialdehyde between two groups.
Conclusion: Consumption of curcumin capsules improved the lipid profile and decreased the fructosamine and lipid peroxidation
Nayereh Parsaeyan,
Volume 8, Issue 1 (1-2016)
Abstract
Objective: Diabetes Mellitus (DM) is one of the leading causes of death, illness, and economic loss in the world. The present study was attempted to evaluate extract of Foeniculum vulgare (fennel) on lipid profile, lipid peroxidation and activities of amino transferase enzymes in streptozocin induced diabetic adult male rats.
Materials and Methods: The effects of daily oral administration of Foeniculum vulgare extract (50 ,75,100mg/kg) for 30 days on blood glucose ,cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, malondialdehyde (MDA), aspartate amino transferase (AST) and alanine aminotranferase (ALT) were evaluated in normal and streptozotocin induced diabetic rats.
Results: Administration of Foeniculum vulgare extract to diabetic rats decreased blood glucose, total cholesterol, triglycerides, LDL, HDL, MDA, AST, ALT and increased HDL levels.
Conclusion: The present investigation suggested that the treatment with Foeniculum vulgare exhibited beneficial effects on lipid profile, lipid peroxidation and aminotranferase enzymes in streptozotocin induced diabetes in male rats and could be considered for further evaluation in drug development.
Nayereh Parsaeyan, Javad Zavarreza,
Volume 8, Issue 4 (12-2016)
Abstract
Objective: Retinopathy is a microvascular complication of diabetes and leading cause of blindness throughout the world. The proteins as the most chemical substances in the cells are exposed to oxidative damages of free radicals. The aim of this study was to evaluate the values of protein oxidation biomarkers in diabetic patients with retinopathy.
Materials and Methods: This study was done on 30 type 2 diabetic patients with retinopathy as cases and 30 age and sex matched type 2 diabetic patients without retinopathy as controls. We measured HbA1c by Ion exchange chromatography and fasting blood sugar (FBS), cholesterol, triglyceride, urea, creatinine, HDL and LDL, protein plasma carbonyls (PCO), advanced oxidation protein products (AOPPS), SH groups and TAC by spectrophotometry in case and control groups and compared them. Urine micro albumin was measured in both groups and compared.
Results: the mean of HbA1c, cholesterol, LDL-C, creatinine, PCO and AOPPS were significantly higher in cases (P-value<0.001). The mean of TAC and SH groups in case group were significantly less than control group (P-value<0.002).
Discussion: The oxidative stress in diabetic patients with retinopathy caused elevation of protein oxidation and increased progress of diabetic disorders especially eye disorders.
