Showing 3 results for Glycated Hemoglobin A
Somaye Gholami, Nasim Namiranian, Mina Bozorg, Faeze Sherafat-Zarch, Elmira Pourhashemi, Fatemeh Lari, Abolfazl Fallah-Madvari, Masoud Rahmanian,
Volume 11, Issue 1 (3-2019)
Abstract
Objective: There are changes in plasma glucose and HbA1c of type 2 diabetes mellitus (T2DM) patients in different seasons. HbA1c levels may increase during winter season in most T2DM patients without weight gain. In this study, we described the seasonal changes of HbA1c levels in T2DM patients.
Materials and Methods: This analytical cross-sectional study conducted from 2013 to 2017 on 402 patients with T2DM, aged 20–80 years old who referred to Yazd diabetic research center. Body weight, height, waist circumferences (WC), blood pressure (BP), body mass index (BMI), fasting plasma glucose (FPG), 2 hours post-prandial (2hpp), and HbA1c measured and compared during four seasons.
Results: Four hundred and two T2DM patients invited and fulfilled this study. Most of them (56%) were women. The mean age of patients was 58.96 (± 11.10) years old. The mean HbA1c, 2hpp, systolic and diastolic blood pressure were significantly different in four seasons (P-value respectively: 0.022, 0.007, 0.001 and 0.005). The mean difference of HbA1c was significant in the warm and cold seasons (P-value: 0.047). The percentage of people who were below 7% had a significant difference between the warm and cold seasons (P-value: 0.015).
Conclusion: The results of this study showed that, in Yazd with desert climate, postprandial hyperglycemia is more prominent in summer. The seasonal changes of glycemic status are an important factor in management of T2DM patients.
Fatemeh Khodaee, Hojjatollah Nikbakht, Mandana Gholami, Mohammad Ali Babaee-Beigi, Khosrow Ebrahim,
Volume 11, Issue 4 (12-2019)
Abstract
Objective: This study aimed to investigate the effects of moderate to high-intensity aerobic exercise on HbA1c (Glycated hemoglobin), FBS (fasting blood sugar) and cognitive function in mild cognitive impairment prediabetes patients.
Materials and Methods: Seventeen elderly mild cognitive impairment (age 55-70) men and women were selected and were randomly divided into 2 groups as aerobic (n=10) and control (n=10). Six subjects were excluded during the study. Finally, 14 subjects were continued the exercise program. Assessments were done at baseline and 12 weeks after intervention. The 12-weeks aerobic exercise program consisted of 90 min sessions in length 3 days per week under the supervision of the exercise specialist. Cognitive function, HbA1c, and FBS were evaluated. The differences in all variables (one way ANOVA), correlation (Pearson single correlation) and relative changes between baseline and 12 weeks (paired T-tests) were investigated.
Results: HbA1c, FBS decreased significantly in the aerobic group whereas cognitive function increased significantly after 12 weeks aerobic (P-value< 0.05 for all). Also, the change of cognitive function was significantly associated with a change of FBS (r= -0.84) after a 12-week aerobic exercise (P-value: 0.011). Differences between groups in HbA1c, FBS and cognitive function (Mini-Mental State Examination) were not significant.
Conclusion: Aerobic exercise may improve HbA1c, FBS and subsequently cognitive function in prediabetes elderly subjects. Therefore, a decrease in glycemic indicators could lead to improve cognitive function.
Mohammad Reza Salimian, Nastaran Injinari, Reyhaneh Azizi, Haniyeh Nikkhah, Nasim Namiranian,
Volume 16, Issue 3 (8-2024)
Abstract
Objective: Diabetes and thyroid disorders (TD) are two prevalent endocrine conditions in adults. While the association between TD and type 1 diabetes is well documented, the relationship between type 2 diabetes mellitus (T2DM) and TD remains unclear due to its complex mechanisms and the involvement of multiple variables. This study aimed to evaluate the prevalence of TD in patients with T2DM referred to Yazd Diabetes Research Center in 2019.
Materials and Methods: This cross-sectional descriptive study included 411 patients with T2DM. Data were collected using a checklist comprising demographic information (age, sex, type of drug used, duration of diabetes) and clinical and laboratory information. Data were analyzed using SPSS version 24 software.
Results: Among the 411 patients with T2DM, 352 (85.6%) had no TD, 38 (9.24%) had hypothyroidism, and 21 (5.10%) had hyperthyroidism. There were no significant differences among groups in terms of gender (P= 0.269), age (P= 0.154), fasting blood sugar (FBS) level (P= 0.196), type of treatment (P= 0.9), and duration of T2DM (P= 0.138). However, a significant relationship was found between TD and the average level of glycosylated hemoglobin (HbA1c) (P= 0.021).
Conclusion: This study highlights a significant prevalence of TD among patients with T2DM, particularly noting the impact on HbA1c levels. Regular screening for TD in patients with T2DM is recommended to improve glycemic control and overall diabetes management. Further research is needed to elucidate the mechanisms linking TD and T2DM and to develop targeted interventions.
