Showing 2 results for Hs-Crp
Akram Alizadeh, Nahid Bijeh, Elham Hakak Dokht,
Volume 4, Issue 4 (10-2012)
Abstract
Objective: Cardiovascular complications are the major cause of reduced lifetime in diabetic patients. Given that physical activity can play an effective role in reducing these complications, the current study was conducted with the aim of examining the effects of 8 weeks of aerobic exercise on some cardiovascular risk factors in women with type 2 diabetes.
Materials and Methods: Twenty women with Type 2 Diabetes were selected by convenience sampling method and were randomly divided into two experimental (n=11) and control (n=9) groups. The exercise protocol included aerobic exercise training for eight weeks and 3 sessions per week every session lasted for 60 minutes and with intensity of 60-70 percent of maximum heart rate reserve. Blood samples were taken to measure serum high-sensitivity C-reactive protein (hs-CRP), glycemia and serum lipids before and after aerobic training period.
Results: The obtained results indicated a significant decrease in the levels of hs-CRP, fasting glucose and total cholesterol, and a significant increase of HDL in the experimental group than controls (p<0.05). Mean serum concentration of triglycerides and LDL reduced in the experimental group however, this reduction was not statistically significant. None of the changes in the control group were significant except for increase in the plasma triglycerides levels.
Conclusion: According to the results of this study, 8 weeks of aerobic exercise can reduce inflammatory causes as well as glycemia and lipid profile in women with type 2 diabetes that these changes can have a desired effect on reducing the risk of cardiovascular disease in these patients.
Arati Adhe Rojekar, Mohit Vijay Rojekar, Swati B. Ghanghurde, Poonam Lalla,
Volume 14, Issue 1 (2-2022)
Abstract
Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sensitivity C - reactive protein (hs-CPR) level and glycosylated hemoglobin (HbA1c) level in PCOS patients.
Materials and Methods: Female patients visiting the obstetrics and gynecology outpatient department (OPD), aged between 19 and 45 years with a body mass index (BMI) of 25 to 29 kg/m2. The individuals fulfilling the National Institute of Health (NIH) criteria for PCOS; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects.
Results: Two hundred and ten individuals with HbA1c of 5.4% have a higher risk of cardiovascular disorders. The study showed the association between increased cardiac risk as measured by hs-CRP and patients with normal HbA1c values with a sensitivity of 77.2% and specificity of 75.99%. The HbA1c cutoff value can be used in the PCOS patients to assess the cardiac risk due to association of HbA1c cut off value with false positivity rate of 15.24%.
Conclusion: In PCOS patients with chronic low-grade inflammation, IR, and the degree of inflammation associated with HbA1c value was observed.
