Iranian Journal of Diabetes and Obesity
IJDO
Medical Sciences
http://ijdo.ssu.ac.ir
1
admin
2008-6792
2345-2250
8
7
14
8888
13
en
jalali
1405
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1
gregorian
2026
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online
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fulltext
en
Effect of Resistance and Interval Training on Serum Melatonin and Expression of Its Receptors (MTNR1A and MTNR1B) in the Pancreas Tissue of Diabetic Rats
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Objective</span></span></span></b><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">:</span></span></span></b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"> In addition to controlling seasonal and circadian rhythms, </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">melatonin has been recognized as a potential gene associated with type 2 diabetes (T2D)</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">. </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">This study</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"> aimed to investigate the impact of resistance and interval training on serum melatonin and its receptors expression (</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">MTNR1A, MTNR1B</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">) in pancreatic tissue of type 2 diabetic rats</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Materials and Methods</span></span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">To achieve this, T2D was established in 21 male Wistar rats through an 8-week high-fat diet followed by an intraperitoneal injection of STZ (25 ml/kg)</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">, then were divided to </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">control (no exercise), resistance (resistance training), and interval (interval training) groups</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">. Exercise interventions lasted 8 weeks (5 time/weekly). </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Fasting glucose, serum insulin and melatonin, beta cell function, MTNR1A and MTNR1B expression in pancreatic tissue were assessed 48 hours following lasting exercise and analyzed among groups using a one-way ANOVA test.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Results</span></span></span></b><b><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Both </span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">resistance and interval training </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">led to significant increase in insulin and beta cell function and significant decrease in glucose, serum melatonin, </span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">MTNR1A</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"> and MTNR1B expression in pancreatic tissue compared with control group (<i>P</i>< 0.05). Significant difference were not observed in all variables between interval and resistance groups</span></span></span> <span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">(<i>P</i>> 0.05).</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:115%"><span style="font-family:"Calibri",sans-serif"><b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Conclusion:</span></span></span></b><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"> Resistance and interval training are associated with increased insulin in T2D rats, and this improvement may be attributed to decreased melatonin and its receptor expression in pancreatic beta cells. </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif">Additional research is required to elucidate alternative mechanisms that contribute to elevated insulin levels.</span></span></span><span dir="RTL" lang="AR-SA" style="font-size:10.5pt"><span style="line-height:115%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span><br>
Type 2 diabetes, Melatonin receptors expression, Insulin synthesis, Exercise training, Beta cell function
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0
http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-477&slc_lang=en&sid=1
Saeed
Karkehabadi