en تخصصي Special پژوهشي Research Objective: The aim of the present study is assessment of insulin resistance (IR) in obese women by TyG-Index and compared with the HOMA-IR index. Materials and Methods: This cross-sectional study was performed on 61 obese women aged 18-45 years. Weights, height, waist circumference (WC) were measured and body mass index (BMI) was calculated and recorded. A sample of fasting serum was collected to determine the glucose, triglyceride, insulin, total cholesterol, HDL-C and LDL-C concentration. HOMA-IR and TyG-Index were calculated as markers of insulin resistance. Results: The mean age of the precipitants was 32.5 ±0.79 years old and the mean weight was 86.0±1.7 Kg. The number of people with IR who determined by HOMA and TyG index were 21(34%) and 36(61%), respectively. There was a significant relationship between HOMA-IR and TyG Index, r= 0.044 (P<0.001). Conclusion: TyG index represents a useful and accessible tool for assessment of IR instead HOMA_IR in Iranian population, but more researches with greater sample size and via gold standard lab test need to evaluate the specificity and sensitivity of this new method. TyG-Index, HOMA-IR, Obesity 23 27 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-69&slc_lang=en&sid=1 Fahimeh Mohammadabadi No Students of MSc, Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. Zahra Vafaiyan No Students of MSc, Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. Seyed Mehran Hosseini No Department of Physiology, Golestan University of Medical Sciences, Gorgan, Iran. Mohammad Aryaie No Deputy of Research, Golestan University Medical Sciences, Gorgan, Iran. Samira Eshghinia Yes PhD of Nutrition; Metabolic Disorders Research Center, Departments of Biochemistry and Nutrition. Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.