en عمومى General پژوهشي Research OBJECTIVE: To evaluate the relationship between serum level of testosterone and sex hormone-binding globulin in men with type 2 diabetes. MATERIALS AND METHODS: In this case-control study, forty men aged 40-70 with type 2 diabetes mellitus were randomly selected and compared with 40 non-diabetic men. The two groups were matched for their age and BMI. After complete observation and examination, fasting blood sugar, postprandial blood sugar, total and free testosterone, sex hormone-binding globulin and HbA1c were measured. RESULTS: The mean serum level of total testosterone was 9.65 ± 2.16 mg/dl in diabetic patients and 12.77 ± 3 mg/dl in non-diabetic subjects which was significantly different (P = 0.0001). The mean value of free serum level of testosterone was significantly higher in non-diabetic group (14.96 ± 4.97 mg/dl) in comparison with diabetic group (9.55 ± 8.14 mg/dl, P = 0.0001). CONCLUSION: In this study we found a lower level of total testosterone, free testosterone, and in lesser extent sex hormone-binding globulin in men with type 2 diabetes comparing to non-diabetic men. Serum testosterone, Hormone-binding globulin, Type 2 diabetes 12 15 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-3-20&slc_lang=en&sid=1 Mohammad Afkhami–Ardekani Yes Laleh Borgian No Javad Mohiti -Ardekani No Zohreh Chiti No Maryam Rashidi No Laila Azod No