en تخصصي Special پژوهشي Research <p><strong>Objective:</strong> In patients with diabetes mellitus, increased rate of lipoprotein oxidation and oxidative stress have important role in diabetic angiopathy, including nephropathy. We designed a study for comparing the level of Ox-LDL in diabetic patients with Macro-albuminuria, Micro-albuminuria, versus Normo-albuminuric.</p> <p><strong>Materials and Methods:</strong> One hundred and thirty five patients with type 2 diabetes mellitus who had been referred to the Yazd Diabetes Clinic, from 1391 through 1392, were enrolled to our study. The 24 hours urinary albumin excretion was measured and Macro-albuminuria defined as albumin excretion of greater than 300mg per day and below 30mg per day in normo-albuminuric group and between 30-300mg defined as Micro-albuminuria group. Plasma level of OX-LDL was measured.</p> <p><strong>Results:</strong> The plasma OX-LDL level in patients with Macro-albuminuria was higher than those in Normo-albuminuric group, (16.1&plusmn;3.6 U/ml versus 8.6&plusmn;1.7 U/ml). There was a significant correlation between the OX-LDL and urine albumin in Macro-albuminuria and Micro-albuminuria groups. There was no significant correlation between the OX-LDL and HbA1C level and diabetes duration.</p> <p><strong>Conclusion:</strong> Significantly elevated plasma OX-LDL in patients with Macro-albuminuria suggests that OX-LDL may play an important role in the progression of diabetic nephropathy.</p> Diabetic mellitus, Oxidized LDL, Nephropathy. 118 123 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-116&slc_lang=en&sid=1 Azam Ghaneei No Assistant Professor in Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Safar Ali Dehghani No PhD Student in Health Care Management. Azimeh Kadkhodazadegan yazd Yes Medical Student, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mahmood Vakili No Associate Professor in Community Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran