en تخصصي Special پژوهشي Research <p><strong>Objective:</strong> Diabetes mellitus (DM) is a common metabolic. One of the unknown complications of DM is cognitive disorders. Different types of cognitive impairment caused by DM may affect the quality of life, self-management of diabetes, and glycosylated hemoglobin. This study aimed to determine the prevalence of cognitive impairment and its relationship with glycosylated hemoglobin (HbA1c), diabetes self-management, and quality of life among diabetic patients.</p> <p><strong>Materials and Methods:</strong> This cross-sectional study was performed on 350 patients with type II diabetes (T2DM) admitted to Shiraz University of Medical Sciences clinics for 7 months. All the participants completed the brief psychological, demographic, quality of life, and self- management profile questionnaires. Then, HbA1c levels were examined. The data were analyzed using the SPSS statistical software, version 16.</p> <p><strong>Results</strong><strong>: </strong>According to the results, 40.3% of the patients had normal cognition, while 44.9% and 14.9% had mild and moderate cognitive impairment, respectively. Moreover, a significant relationship was found between the cognitive impairment score and HbA1c level, some aspects of quality of life, and self-management profile.</p> <p><strong>Conclusion: </strong>DM was associated with changes in cognition. Besides, cognitive impairment was associated with some domains of quality of life and self-management profile; as the cognitive impairment score increased, quality of life and self-management profile increased, as well. Also, a decreasing trend was observed in HbA1c levels in moderate to normal cognitive impairment states.</p> Cognitive impairment, Type II diabetes, Quality of life, Self-management profiles, Hemoglobin A1c 35 40 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-135&slc_lang=en&sid=1 Marzieh Moattari No Nursing Education Department, Fatemeh (PBUH) School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. Sheida Jamalnia No Department of Nursing Education, Fatemeh (PBUH) School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. Parisa Mansoori Yes Department of Medical-Surgical Nursing, Nursing Education Department, Fatemeh (PBUH) School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. Arash Mani No University Counseling Center, Shiraz University of Medical Sciences, Shiraz, Iran. Mohammad Hossein Dabbaghmanesh No Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Mehrab Sayadi No Master of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran