en تخصصي Special پژوهشي Research Objective: The purpose of the present study was investigation of eight weeks high intensity interval (HIIT) along with curcumin supplementation on liver Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration among diabetic male rats.<br> Materials and Methods: Thirty-two male mice were divided to four groups of control-diabetic, exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic. Eight weeks&rsquo; aerobic training schedule was five weekly sessions for the two exercise groups, which each session executed on animal treadmill with speed of 24 (m/min), steep of 0&deg;, and entire span of 18 min. The two supplementary groups were being fed daily amount of 50 (mg/kg) curcumin supplementary, by using the gavage technique. The rats were killed and liver tissues were separated, after the eight weeks&rsquo; schedule. Thereafter, in order to study variations of GPX and MDA enzymes, Kits of Zelbio Co. were implemented.<br> Results: Activity levels of GPX enzyme and MDA concentration of the three groups of exercise-diabetic, supplementary-diabetic, and exercise-supplementary-diabetic in order increased and decreased than those of the control-diabetic one, significantly (P&le;0.05).<br> Discussion: both exercise and curcumin can be recommended as effective interventions on improvement of Glutathione Peroxidase (GPX) Activity & Malondialdehyde (MDA) Concentration of the liver, in diabetic condition. GPX, MDA, Curcumin, HIIT, Diabetic male rats 129 134 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-149&slc_lang=en&sid=1 Abdol-Majid Emami Yes PhD student of Biochemistry and Exercise Metabolism, Islamic Azad University, Central Tehran branch, Tehran, Iran. Hasan Matin Homaee No Assistant Professor, Islamic Azad University, Central Tehran branch, Tehran, Iran. Mohammad Ali Azarbayjani No Professor, Islamic Azad University, Central Tehran branch, Tehran, Iran.