en تخصصي Special پژوهشي Research Objective: Blood group as a genetic trail can be associated with type 2 diabetes. The aim of this research was to determine the distribution of ABO frequency and RH blood groups in type 2 diabetic patients referred to Yazd diabetes center.<br> Materials and Methods: In this research 1502 type 2 diabetes patients of Yazd diabetes center were selected and checked for blood group ,age, sex, duration of diabetes, nephropathy, retinopathy ,diabetes control and familial history of diabetes. Data were analyzed on SPSS-21.<br> Results: From 1502 patients participated in this study 995 were male (66.2%) and 507 female (33.8%). The mean age (standard deviation) of patients was 52&plusmn;10.46. About 541 participants (36%) had O blood group, 431 (28%) A, 379 (25%) B, and 150 (10%) AB. About 90.8% patients were RH. The most frequency was observed in blood group O+ (30.9%) and the patients with blood group of AB- had the lowest frequency (0.5%) among patients. The various blood groups were not different in following subgroups; Familial History (P=0.6), diabetes duration (P=0.32), retinopathy (P=0.64), nephropathy (P=0.69), and hypertension (P=0.33). But HbA1c<7 and blood groups were significantly different (P=0.03).<br> Discussion: The blood group O+ was the most frequent and AB- was the&nbsp; least frequent among blood groups in this study .But for evaluation of&nbsp; relationship between blood group and diabetes the prospective studies are suggested.<br> <br> &nbsp; Diabetes, Blood group, ABO. 191 195 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-158&slc_lang=en&sid=1 Reyhane Azizi No Assistant Professor of Endocrinology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Simin Manoochehry No Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Seyd Kazem Razavi-Ratki No Assistant Professor of Nuclear medicine, Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Seyed Mostafa Seyed Hosseini No Assistant professor of Cardiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mahmoud Vakili No Associated Professor of Community Medicine, Health Monitoring Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Nasim Namiranian Yes Assistant Professor of Community Medicine, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.