en تخصصي Special پژوهشي Research Objective: Diabetic patients suffer from different types of complications associated with peripheral nerves. A clear manifestation of these complications is found in the mouth where neuropathies commonly occur. The measurement of electrical stimulation threshold of teeth signifies premature involvement of peripheral nerves in the teeth. The aim of present study is to compare pulp tester response in uncontrolled type II diabetic (T2DM) patients and people with normal systemic conditions.<br> Materials and Methods: In this case-control study, 63 subjects in two groups of diabetic patients (n=30) and control (n=33) were studied. For each group, the electrical stimulation thresholds of higher-jaw central teeth were measured and recorded. The collected data was analyzed via SPSS Software (version. 17). The difference between mean thresholds of electrical stimulation of teeth between the two groups was verified based on T-test. In addition, Chi-square test was used for determination of association between qualitative variables. In this study, the significance level was presumed to be P-value<0.05.<br> Results: The mean threshold of electrical stimulation in diabetic patients was 3.8 with standard deviation (SD) 1.01 and in control group was 3.7 (&plusmn;0.9). The difference between two groups was insignificant (P-value:0.483). In addition, the association between age and threshold of stimulation was not significant (P-value:0.06). Conclusion: Despite of observed difference between test and control groups in regard to electrical stimulation threshold, the obtained results were insignificant. This extent of simulation in dental nerves in patients with uncontrolled T2DM and controls was similar. Electrical stimulation threshold, Pulp test, Diabetes, Neuropathy 20 24 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-164&slc_lang=en&sid=1 Jalil Modaresi No Assistant Professor, Department of Endodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Afkhami-Ardekani No Department of Internal Medicine, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Fatemeh Mokhtari No Assistant Professor, Department of Endodontics, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Alireza Salmani-Qahyazi Yes Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Hosein Amirzade-Iranaq No Student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. . Universal Network of Interdisciplinary Research in Oral and Maxillofacial Surgery (UNIROMS), Universal Scientific Education and Research Network (USERN), Tehran, Iran. 6. International Otorhinolaryngology Research Association (IORA), Universal Scientific Education and Research Network (USERN), Tehran, Iran