en تخصصي Special پژوهشي Research <strong>Objective:</strong> The purpose of this study was to investigate the effect of exercise training and curcumin supplementation combination on the lipid profile of inactive middle-aged men.<br> <strong>Materials and Methods</strong><strong>:</strong> This is an experimental study. The studied population was middle-aged men who were categorized as inactive. <a name="OLE_LINK11"></a><a name="OLE_LINK10">The mean (&plusmn; standard deviation) age of participants was 3</a>4/82 (&plusmn;6.54). They were 60 volunteers who were assigned to four groups by simple randomization, including <a name="OLE_LINK170"></a><a name="OLE_LINK169">the training group (</a><a name="OLE_LINK12">N = 15</a>), <a name="OLE_LINK17"></a><a name="OLE_LINK16">the </a><a name="OLE_LINK22"></a><a name="OLE_LINK21"></a><a name="OLE_LINK20">training-curcumin </a>group (N = 15), the curcumin group (N = 15), and the control group (N = 15).<a name="OLE_LINK19"></a><a name="OLE_LINK18">Three training sessions were carried out weekly</a> for eight consecutive weeks, including weight training and running on a treadmill with 65 percent of maximum oxygen consumption for the training group. The <a name="OLE_LINK24"></a><a name="OLE_LINK23"></a><a name="OLE_LINK300"></a><a name="OLE_LINK299">curcumin </a>was administered as 80 mg gelatin capsule 5 days in a week for eight consecutive weeks<a name="OLE_LINK32"></a><a name="OLE_LINK31">. Twenty-four hours before the first session and 48 hours after the</a> last session, blood samples were taken and transferred to the laboratory. The statistical analyses were done via SPSS Software (Version 22).<br> <strong>Results:</strong> There was a significant difference between the interactive effects of eight weeks <a name="OLE_LINK47">of </a><a name="OLE_LINK39"></a><a name="OLE_LINK38">combined exercise training</a> and supplementation of curcumin on triglyceride and plasma high density lipoprotein (HDL) (<em>P</em>-value: 0.008 and 0.002), but their effect on low density lipoprotein (LDL) and cholesterol was not significant <a name="OLE_LINK43"></a><a name="OLE_LINK42">(<em>P</em>-value: 0.06 and 0.42)</a>. Moreover, there was a significant difference between cholesterol, LDL, HDL and triglyceride <a name="OLE_LINK149"></a><a name="OLE_LINK148">in the pre-test and post-test. </a><br> <strong>Conclusion</strong><strong>:</strong> Combined exercise trainings and curcumin extract can be used to improve the lipid profile of inactive middle aged people. Exercise Training, Curcumin, Lipoproteins 61 66 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-197&slc_lang=en&sid=1 Hamid Sedaghat No M.A Student of Exercise Physiology, Yazd Branch, Islamic Azad University, Yazd, Iran. Abbas Fattahi Bafghi Yes Departments of Physical Education, Bafgh Branch, Islamic Azad University, Bafgh, Iran. Abdolmajid Emami No Department of Physical Education, Meybod Branch, Islamic Azad University, Meybod, Iran