en تخصصي Special پژوهشي Research <strong>Objective:</strong> Effect of resistance training on muscle mass increase, blood glucose control, hemoglobin (HbA1c) reduction, on type 2 diabetes (T2DM), has been approved. While injuries and delayed onset muscle soreness (DOMS) may lead to some difficulties in diabetic patients to continue training exercise.<br> The purpose of this study was to investigate the effect of glutamine supplementation (o.1 g / 1kg / each day for 4 weeks) on DOMS, creatine kinase (CK<span dir="RTL"> (</span>contraction and the skin temperature of the elbow flexing muscles in the untrained T2DM patients.<br> <strong>Materials and Methods</strong><strong>:</strong> The research was an experimental study. This study was a double blinded randomized controlled trial. Subjects were randomly assigned into 4 groups of diabetic glutamine (N=10), diabetic placebo of Maltodextrin (N=10), healthy glutamine (N=10) and healthy placebo of Maltodextrin (N=10). Variables were measured before, 24, 48 and 72 Hours after exercise. Data were analyzed by ANOVA and Bonferroni&#39;s post hoc test in SPSS-18 software.<br> <strong>Results:</strong> Glutamine was effective on changes in CK and pain sensation 72 hours after exercise in diabetics. (<em>P</em>-value: 0.0001).In skin temperature was not significant different.<br> <strong>Conclusion</strong><strong>:</strong> Glutamine was not effective in preventing and reducing DOMS, but it may reduce the DOMS period. Type II diabetes, Glutamine, Muscle soreness, Skin temperature 121 129 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-208&slc_lang=en&sid=1 Sayed Abbas Biniaz 0000-0002-9934-6874 No Department of Physical Education, Faculty of Social Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran. Hojatollah Nikbakht 0000-0002-6092-389x Yes Department of Physical Education, Faculty of Social Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran. Hossein Abed Natanzi 0000-0001-6638-1131 No Department of Physical Education, Faculty of Social Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran.