en تخصصي Special پژوهشي Research <strong>Objective:</strong><strong> T</strong>he overweight-related health problems among adolescents are obvious. Resistance training is recognized as a safe and efficacious exercise modality to have health-promoting effects in overweight adolescents. This study aimed to assess the efficacy of circuit resistance training (CRT) in improving inflammatory status, insulin resistance and body composition in overweight male adolescents.<br> <strong>Materials and Methods</strong><strong>:</strong> Twenty overweight adolescent boys (aged: 18.5 (&plusmn;1), weight: 81.1 (&plusmn;4.5), body mass index: 27.7 (&plusmn;0.7)) completed this study. The participants were randomly and equally divided into two groups of control (CG; n=10) and circuit resistance training (CRT; n=10). The CG did their daily routine activities and the CRT group performed its training protocol 3 days a week for 6 weeks. Body composition components and serum variables were measured a day before and after the study. Insulin resistance index was measured by HOMA-IR.<br> <strong>Results:</strong> The subjects in the CG showed significantly increased changes compared with pre-training values. Moreover, significant changes were found fort the changes of BW (<em>P</em>-value= 0.005), BMI (<em>P</em>-value= 0.001) and BF% (<em>P</em>-value= 0.003) between groups.<br> <strong>Conclusion</strong><strong>:</strong> This study suggested that although six weeks of CRT failed to induce meaningful anti-inflammatory cytokine responses, and to improve body composition and HOMA-IR in overweight adolescent boys, but had protective effects on inflammatory status, HOMA-IR and body composition and prevented them from being deteriorated. Circuit resistance training, Obesity, Anti-inflammatory cytokine response, Insulin resistance, body composition 129 136 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-242&slc_lang=en&sid=1 Hamid Alizadeh 0000-0001-8753-4184 Yes PhD. of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran. Alireza Safarzade 0000-0002-8413-3665 No Associate Professor of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran Talebi-Garakani Elahe 0000-0001-7499-8852 No Associate Professor of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.