en تخصصي Special پژوهشي Research <strong>Objective:</strong> Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL2 and some mitochondrial enzymes of the kidney in diabetic rats.<br> <strong>Materials and Methods</strong><strong>:</strong> In this experimental study, 45 male wistar rats (200-300 gr) were simple randomly divided into six groups: 1) placebo group, 2) healthy control group, 3) diabetic control group, 4) diabetic group receiving L- carnitine, 5) diabetic group of aerobic training and 6) diabetic group of aerobic training and recipient of L-carnitine. Rats with a serum glucose level higher than 300 mg/ dL were considered diabetic. L-carnitine recipients received 100 mg of L-carnitine daily orally. The dependent variables of the study were measured 24 hours after the last training program session by ELISA in kidney tissue. Data were analyzed by Shapiro- Wilk and two way ANOVA and Tukey post hoc test at <em>P</em>-value< 0.05.<br> <strong>Results:</strong> The results showed that the combined effect of aerobic training and supplementation of L-carnitine on Bcl2 factor of kidney tissue of rats with diabetes has a significant effect (<em>P</em>-value: 0.019). But aerobic exercise (<em>P</em>-value: 0.969) and supplementation of L-carnitine (<em>P</em>-value: 0.584) were not significant.<br> <strong>Conclusion</strong><strong>:</strong> The results of this study showed that the combined effect of aerobic exercise and supplementation of L-carnitine on CPT2 and Malonyl COa and Bcl2 have a significant effect on the kidney of diabetic rats. Also, exercise alone and consumption of L-carnitine alone do not have a significant effect.<span dir="RTL"></span> Aerobic training, L-carnitine, Diabetes, CPT2, Malonyl CO A, Bcl2, Kidney. 145 151 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-243&slc_lang=en&sid=1 Ali Fakourian No Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran Homaee Hasan Matin Yes Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran Mohammad Ali Azarbayjani No Department of Physical Education and Sport Scince, Islamic Azad University, Central Tehran Branch, Tehran, Iran Parvin Farzanegi No Department of Physical Education and Sport Scince, Islamic Azad University, Sari Branch, Sari, Iran.