en تخصصي Special پژوهشي Research <strong>Objective:</strong> Thepurpose of this study was to investigate the effect of 6 weeks of HIIT training combining nano-curcumin supplement on antioxidant defense and lipid degradation in overweight girls.<br> <strong>Materials and Methods</strong><strong>:</strong> The research method was semi-experimental study. Accordingly, 48 overweight girl students were randomly divided into four groups: training (n=12), training-supplement (n=12), supplement (n=12) and control group (n=12). Supplement groups consumed 80 mg nano-curcumin capsule daily. Training groups performed an exercise protocol of HIIT training with maximum heart rate for 6 weeks (three sessions per week).&nbsp;The control group did not have any regular exercise.&nbsp;Blood samples were obtained before and after training period for&nbsp;antioxidant indicators and lipid degradation&nbsp;measurement. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively.&nbsp;<br> <strong>Results:</strong> A significant increase was observed in serum levels of Malondialdehyde (<em>P</em>-value= 0.004) in the training group after 6 weeks. Also, there was a&nbsp;significant increase in serum Glutathione (<em>P</em>-value= 0.001), Superoxide dismutase (<em>P</em>-value= 0.006) and Catalase indexes (<em>P</em>-value= 0.01) in the supplement group. Moreover, a significant increase in catalase (<em>P</em>-value= 0.001), glutathione (<em>P</em>-value= 0.006), superoxide dismutase (<em>P</em>-value= 0.015) and glutathione peroxidase indexes (<em>P</em>-value= 0.05) and a significant decrease in malondialdehyde (<em>P</em>-value= 0.009) were observed in the training supplement group.<br> <strong>Conclusion</strong><strong>:</strong> A positive antioxidant effect was seen, so taking curcumin supplement along with exercises may have beneficial effects on reinforcement the antioxidant system and prevention of lipid peroxidation in overweight individuals. Turmeric, Overweight, High-Intensity Interval Training, Antioxidants 173 180 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-247&slc_lang=en&sid=1 Somaye Fakhri 0000-0003-0056-8184 No Master Student, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. saeed shakeryan 0000-0002-3752-8525 Yes Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Aliakbar Alizadeh 0000-0001-7846-6503 No Assistant Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran Ali Shahryari 0000-0001-9008-2692 No Professor, Department of Basic Sciences, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz; Iran