en تخصصي Special پژوهشي Research <strong>Objective:</strong> Menopause is a normal biological process associated with hormonal and metabolic changes. The purpose of this study was to investigate the effect of combined training on estradiol levels and some metabolic risk factors in obese and overweight postmenopausal women.<br> <strong>Materials and Methods</strong><strong>:</strong> In this quasi-experimental study, 24 postmenopausal women were randomly divided into experimental and control groups. Subjects of experimental group were performed 10 weeks of combined training including resistance and aerobic exercises. Control group did not participate in any exercise training. Fasting glucose, insulin, estradiol, HOMA-IR and body fat percentage measured at the beginning and after training.<br> <strong>Results:</strong> There were no significant differences in estradiol (<em>P</em>-value: 0.87), glucose (<em>P</em>-value: 0.09), insulin (<em>P</em>-value: 0.11), HOMA-IR (<em>P</em>-value: 0.08) and body fat percentage (<em>P</em>-value: 0.24) between experimental and control groups after combined exercise training.<br> <strong>Conclusion</strong><strong>:</strong> This study showed that 10 weeks of moderate-intensity combined exercise training has no effect on serum estradiol level and insulin resistance in overweight/obese postmenopausal women. Estradiol, Metabolic risk factors, Combined training, Postmenopausal women 206 211 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-255&slc_lang=en&sid=1 Masomeh Sarmadiyan 0000-0002-6479-7229 No MSc, Department of Exercise Physiology, Faculty of Physical Education, Islamic Azad University, Karaj Branch, Karaj, Iran. Davood Khorshidi 0000-0002-4740-9159 Yes Assistant Professor, Department of Exercise Physiology, Faculty of Humanities Sciences, Islamic Azad University, Saveh Branch, Saveh, Iran. Mohammad Karimi 0000-0002-6388-622X No Assistant Professor, Faculty of Science, Qom University of Technology, Qom, Iran