en تخصصي Special پژوهشي Research <strong>Objective:</strong> Diabetes Mellitus (DM) is one of the most common endocrine diseases with many systemic complications such as oral manifestations. The present study aimed to compare the oral manifestations frequency in diabetic patients and healthy subjects.<br> <strong>Materials and Methods</strong><strong>:</strong> This cross sectional study was conducted during 2016-17 on subjects came to Yazd Diabetic Research Center. In this study, 181 type 2 diabetic patients (T2DM) and 181 healthy individuals, based on convenient sample method, were included. Two groups were compared for basic information and oral manifestations including candidiasis, oral lichen planus (OLP), periodontitis, xerostomia, delayed oral wound healing, geographic tongue, gingival hyperplasia, fissured tongue, burning mouth and finally at least one of these lesions.<br> <strong>Results:</strong> The frequency of candidiasis, OLP, periodontitis, delay oral wound healing, geographic tongue, xerostomia and at least one of lesions in diabetics were significantly higher than control group (<em>P</em>-value< 0.001). After regression analysis and adjusting for confounding factors, candidiasis, periodontitis and xerostomia in diabetics were significantly more prevalent than non-DM patients with odds ratio of 15.16 (1.80-127.57), 9.58 (4.68-19.63) and 78.639 (10.05-615.231) respectively.<br> <strong>Conclusion</strong><strong>:</strong> Xerostomia, candidiasis and periodontitis were significantly more prevalent in T2DM than Non-T2DM persons. Therefore, increasing awareness on oral manifestations in this group is recommended for timely diagnosis and referring to an oral medicine. Oral complications, Oral manifestations, Diabetes mellitus, Oral diseases 63 68 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-273&slc_lang=en&sid=1 Akram Ghadiri-Anari 0000-0002-9430-4894 No Associate Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Khatereh Kheirollahi 0000-0003-4177-0426 No Assistant Professor, Department of Oral Medicine, Dental Faculty of Shahid Sadoughi University of Medical Science, Yazd, Iran Narjes Hazar 0000-0002-2623-7685 No Community Medicine Specialist. Department of Community Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Nasim Namiranian 0000-0002-5133-6204 No Assistant professor of Community & Preventive Medicine, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Maryam jalili sadrabad 0000-0002-4937-1676 Yes Assistant professor, Department of Oral Medicine, Dental Faculty of Semnan University of Medical Science, Semnan, Iran Mohsen Akhondi-Meybody 0000-0002-7173-834X No Associated professor of internal medicine, Gastroentrology Department, Shahid sadoughi hospital, faculty of medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mina Askari Mayani No Master of Medical Library and Information Science, library of Dental Faculty of Semnan University of Medical Science, Semnan, Iran