Iranian Journal of Diabetes and Obesity
IJDO
Medical Sciences
http://ijdo.ssu.ac.ir
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admin
2008-6792
2345-2250
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8888
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jalali
1399
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gregorian
2020
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fulltext
en
The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats
تخصصي
Special
پژوهشي
Research
<strong>Objective:</strong> The goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (TNF-<strong>α), </strong>hypoxia-inducible factor-1 alpha (HIF-1<strong>α)</strong> and vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats<strong>.</strong><br>
<strong>Materials and Methods</strong><strong>:</strong> In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), diabetic aerobic training, diabetic control and healthy control (n=10). Induction of type 2diabetes (T2DM) was done by intraperitoneal infusion of streptozotocin. The progressive aerobic training protocol entailed 4 weeks, 5 sessions per week running on treadmill at velocity of 20 m/min for 60 min. The gene expression of TNF-α, VEGF and HIF-1α were measured by real time & PCR. One way analysis of variance and bonferroni test were applied to analysis the data. The significant level was set at <em>P</em>-value< 0.05.<br>
<strong>Results:</strong> The results indicated that the aerobic training induced significant decrease in TNF-α mRNA (<em>P</em>-value< 0.001) and significant increase in HIF-1α mRNA (<em>P</em>-value< 0.001) and VEGF mRNA (<em>P</em>-value< 0.001) compared to diabetic control group.<br>
<strong>Conclusion</strong><strong>:</strong> It appears that aerobic training with reduction of TNF-α issues an affirmative effect on angiogenesis, as a result, it improves diabetic cardiac.
Angiogenesis process, Aerobic training, Tumor necrosis factor alpha, Hypoxia-inducible factor-1 alpha, Vascular endothelial growth factor
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http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-277&slc_lang=en&sid=1
Fariba
Bakhtiari