en تخصصي Special پژوهشي Research <strong>Objective:</strong> Obesity is a medical problem that increases the risk of health problems like diabetes. Hormones secreting from fat tissue, Leptin, are correlated with body mass index. Leptin reduces the person&#39;s appetite by acting on specific centers of their brain to reduce their urge to eat. And insulin, a hormone produced by the pancreas, is essential for regulating carbohydrates and the metabolism of fat. A positive relationship between leptin levels and insulin resistance in children showing in this study is to determine the effect of continues-endurance and interval-endurance on leptin serum levels and insulin resistance in over-weighted youths.<br> <strong>Materials and Methods</strong><strong>:</strong> This study is a semi-experimental design. Thirty boys were voluntarily selected as a matched two experimental groups and a control. Physical profiles included aged 16-19, BMI; 37.75 (&plusmn;4.46) KG/M², base functional capacity: 32.8 (&plusmn;3.6) ml/kg/min which dividing by three equal groups: the submaximal training interval, a continuum and interval and control group performed the submaximal running program for six weeks on 3 D/W. The selected parameters were evaluated for an intervention pre and post-conditions.<br> <strong>Results:</strong> weight and body mass index variables were decreased by about 2.5-3% after exercise intervention. Plasmatic leptin levels were reduced by about 45% in the continuum and interval control groups. HOMA-IR & QUICKI indexes altered in the EG (8.9 %, 7.8%) (<em>P</em>-value < 0.05).<br> <strong>Conclusion</strong><strong>:</strong> Presumably, 2 exercise program patterns lower than lactate threshold could change body composition profile, basal leptin level, and blood glucose /insulin concentrations, which probably induced changes in resistance to insulin. Leptin hormone, Insulin hormone, Submaximal exercises, Resistance, Obesity 210 217 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-293&slc_lang=en&sid=1 Farzad Nazem 0000-0003-4040-0837 Yes PhD in Work Physiology, Exercise Physiology Department, Sports Sciences Faculty .Hamedan Bu-ali Sina. Hamedan, Iran Salman Lotfi 0000-0002-8617-4006 No MSC in Sports Physiology, Sports Sciences Faculty .Hamedan Bu-ali Sina. Hamedan, Iran