Iranian Journal of Diabetes and Obesity
IJDO
Medical Sciences
http://ijdo.ssu.ac.ir
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admin
2008-6792
2345-2250
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8888
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jalali
1399
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gregorian
2020
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online
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fulltext
en
The Effect of High Intensity Intermittent Training (HIIT) on GLP-1R Expression in Pancreas Tissue and Serum Insulin of Male Wistar Rats with Type 2 Diabetes Mellitus
تخصصي
Special
پژوهشي
Research
<strong>Objective:</strong> Insulin secretion and insulin resistance are associated with incidence and severity of type 2 diabetes mellitus (T2DM). This study aimed to assess the effect of high intensity intermittent training (HIIT) on GLP-1R expression in pancreas tissue and serum insulin of T2DM rats.<br>
<strong>Materials and Methods</strong><strong>:</strong> In this quasi-experimental study, T2DM induced by intraperitoneal injection of streptozotocin-Nicotinamide in 16 male wistar rats aged 10 weeks (220 – 20 g). The rats were divided into control (no-training, n= 8) and HIIT (5 times/ week/12-week, n= 8) groups. GLP-1R expression in pancreas tissue, fasting glucose and serum insulin were measured 48 h after lasted exercise of exercise and control groups. Independent and paired T-test was used to compare variables between 2 groups.<br>
<strong>Results:</strong> HIIT resulted in significant increase in GLP-1R expression compared to control subjects (<em>P</em>-value: 0.023). Fasting glucose decreased (<em>P</em>-value< 0.0001) and serum insulin increased (<em>P</em>-value< 0.0001) in response to HIIT when compared to control subjects.<br>
<strong>Conclusion</strong><strong>:</strong> HIIT can improve insulin secretion in male rats with T2DM and this improvement can be attributed to increased GLP-1R expression in pancreas tissue in response to training protocol.
Exercise training, Elderly, Endothelial cells, microRNAs
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http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-295&slc_lang=en&sid=1
Mohammad
Karimi