en تخصصي Special پژوهشي Research <strong>Objective:</strong> Exercise and herbal medicine Berberine are known as anti-inflammatory agents<em><span dir="RTL">.</span></em> This study aimed to evaluate the effect of 4-weeks of endurance training and Berberine Chloride (BC) consumption on inflammatory factors and glycemic index in male wistar diabetic rats.<br> <strong>Materials and Methods</strong><strong>:</strong> In an experimental trial, 36 male wistar rats divided into 6 groups of 6 rats including 1) control, 2) 15 mg/kg BC, 3) 30 mg/kg BC, 4) endurance training, 5) endurance training with 15 mg/kg BC and 6) endurance training with 30 mg/kg of BC. During 4 weeks, rats in groups 2, 3, 5, and 6 received BC by gavage at specified doses, and rats in groups 4- 6 also ran on the treadmill at speeds of 10-15 m/min for 10-30 minutes. For statistical analysis of data-independent sample T-test, two-way ANOVA were used (<em>P</em>-value= 0.05).<br> <strong>Results:</strong> Training and BC significantly increased function of pancreatic beta cells and reduced FBS, TNF-&alpha;, and IL- 6 (<em>P</em>-value= 0.001); Training significantly increased VO_2maxand insulin; interaction of training and BC on an increase of VO_2maxand reduction of TNF-&alpha; were significant (<em>P</em>-value= 0.001) and 30 mg/kg BC reduced TNF-&alpha; and FBS much more than 15 mg/kg BC (<em>P</em>-value= 0.001).<br> <strong>Conclusion</strong><strong>:</strong> It appears that Endurance training and BC can decrease glycemic index and inflammatory markers of diabetes and the effects of BC is dose-dependent, so that the 30 mg/kg BC is more effective rather than the 15 mg/kg BC. Training, Berberine chloride, Glycemic index, Inflammation, Diabetes 226 232 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-296&slc_lang=en&sid=1 Hossein Heidari 0000-0001-7100-4904 No Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Mohammad Ali Azarbayjani 0000-0002-3502-7487 Yes Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Maghsoud Peeri 0000-0003-1415-7319 No Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Parvin Farzanegi 0000-0001-9122-3952 No Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran Seyed Ali Hosseini 0000-0003-2182-3068 No Department of Exercise Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran