en تخصصي Special پژوهشي Research <strong>Objective:</strong> Renal failure is a complication of diabetes. It can be the risk factor of cardiovascular disease. This study aimed to evaluate the effect of exercise course and Aloe-Vera supplementation on renal function and lipid profile in type 2 diabetes mellitus (T2DM) patients.<br> <strong>Materials and Methods</strong><strong>:</strong> This is a clinical trial double blind with pre-test and post hoc test analyses with a control group. The studied population included a group of T2DM diagnosed patients among whom 24 men (40-60years) were selected voluntarily and purposefully and were classified into three groups by balanced block randomization method, exercise(E), exercise + supplement (E+S), and control (C), (n=8/group). Combined exercise was planned in two 12-minute repetitive sets with 70% 1RM. Then the participants ran for two 10- minute sets with 70-75% maximum heart rate intensity on treadmill. E+S participants consumed 500 mg/day Aloe Vera for 6 weeks. Obtained data by SPSS-19 software were analyzed using co-variance analysis method with Bonferroni post hoc test (<em>P</em>-value<0/05).<br> <strong>Results:</strong> Results showed that E and E+S significantly improved GFR (<em>P</em>-value=0.011) and E with or without Aloe-Vera consumption decreased creatinine levels (<em>P</em>-value=0.042) and increased HDL levels (<em>P</em>-value˂0.001). The results demonstrated that LDL and TG levels showed no significant difference in reaction to the combined exercise and supplementation.<br> <strong>Conclusion</strong><strong>:</strong> Combined exercise along with Aloe-Vera supplementation has had significant effect on improving renal factors and lipid profile of T2DM diagnosed patients Combined exercise, Type 2 diabetes, High density lipoprotein, Low density lipoprotein, Creatinine 40 47 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-303&slc_lang=en&sid=1 Ghasem Ahmadi Nasab 0000-0002-8440-6571 No MA. Candidate in Exercise Physiology, Department of Sport Sciences, Education and Psychology Faculty, University of Sistan and Baluchestan, Zahedan, Iran Reza Delavar 0000-0002-8965-3184 Yes Assistant Professor, Department of Sport Sciences, Education and Psychology Faculty, University of Sistan and Baluchestan, Zahedan, Iran Hamed Taheri 0000-0001-6695-9888 No Assistant Professor of Internal Medicine, Cellular and Molecular Research center, Medical Science University of Zahedan, Zahedan, Iran