Iranian Journal of Diabetes and Obesity
IJDO
Medical Sciences
http://ijdo.ssu.ac.ir
1
admin
2008-6792
2345-2250
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8888
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en
jalali
1400
9
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gregorian
2021
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online
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fulltext
en
Effect of Black Grape Seed(Vitis Vinifera) Extract Consumption with Moderate-Intensity Aerobic Training on the Expression of MicroRNAs in Type 1 Diabetic Cardiac Tissue Rats
تخصصي
Special
پژوهشي
Research
<strong>Objective:</strong> This study aimed to evaluate the effect of consuming grape seed extract with moderate-intensity aerobic training on the expression of miR-126 and miR-29 in the cardiac tissue in type 1 diabetic male rats.<br>
<strong>Materials and Methods</strong><strong>:</strong> 40 rats with an initial weight range of 160-220 g were divided into five groups: Training + Extract, Training, Extract, Diabetic / Control, and Healthy / Control. Aerobic training program was moderate intensity and rats performed aerobic training for 60 minutes a day with the intensity 70 to 75% of maximum oxygen consumption (28 meters per minute). Grape seed extract was also administered by gavage at a dose of 40 mg/kg per day.<br>
<strong>Results:</strong> Expression of both miRNAs in the three groups of training + extract, healthy training and control was significantly higher than the two groups of extract and diabetic control (<em>P</em>-value= 0.001). The difference between the three groups of training + extract, healthy training and control and also the difference between the two groups of extract and diabetic control were not significant (<em>P</em>-value> 0.05).<br>
<strong>Conclusion</strong><strong>:</strong> Aerobic training may be able to prevent cardiac disease caused by type 1 diabetes<em><span dir="RTL">.</span></em><strong><span dir="RTL"></span></strong>
Diabetes, Aerobic training, Grape Seed, miR-126, miR-29a
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http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-331&slc_lang=en&sid=1
Maryam
Shirani Bidabadi