en تخصصي Special پژوهشي Research <strong>Objective:</strong> Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sensitivity C - reactive protein (hs-CPR) level and glycosylated hemoglobin (HbA1c) level in PCOS patients.<br> <strong>Materials and Methods</strong><strong>:</strong> Female patients visiting the obstetrics and gynecology outpatient department (OPD), aged between 19 and 45 years with a body mass index (BMI) of 25 to 29 kg/m². The individuals fulfilling the National Institute of Health (NIH) criteria for PCOS; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects.<br> <strong>Results:</strong> Two hundred and ten individuals with HbA1c of 5.4% have a higher risk of cardiovascular disorders. The study showed the association between increased cardiac risk as measured by hs-CRP and patients with normal HbA1c values with a sensitivity of 77.2% and specificity of 75.99%. The HbA1c cutoff value can be used in the PCOS patients to assess the cardiac risk due to association of HbA1c cut off value with false positivity rate of 15.24%.<br> <strong>Conclusion</strong><strong>:</strong> In PCOS patients with chronic low-grade inflammation, IR, and the degree of inflammation associated with HbA1c value was observed.<strong><em><span dir="RTL"></span></em></strong> HbA1c, Polycystic ovary syndrome, hs-CRP, Cardiovascular disorder 9 13 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-333&slc_lang=en&sid=1 Arati Adhe Rojekar 0000-0003-1738-738X No Junior Consultant, Department of IVF, PD Hinduja National Hospital and Research Centre, Mumbai, India. Mohit Vijay Rojekar 0000-0002-8870-9182 No Associate Professor, Department of Biochemistry, Rajiv Gandhi Medical College, Kalwa, Thane, India. Swati B. Ghanghurde 0000-0002-8480-3657 No Department of Pathology, Rajiv Gandhi Medical College, Kalwa, Thane, India. Poonam Lalla 0000-0003-1666-3135 Yes Family Physician, Chembur, Mumbai, India.