Iranian Journal of Diabetes and Obesity
IJDO
Medical Sciences
http://ijdo.ssu.ac.ir
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admin
2008-6792
2345-2250
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8888
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jalali
1400
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gregorian
2022
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Investigating the Relation between LCK Gene Expression with Type 2 Diabetes Patients in Yazd Diabetes Research Center
تخصصي
Special
پژوهشي
Research
<a name="_Hlk85447343">Type 2 diabetes mellitus</a> (T2DM) is characterized by insulin resistance and insulin secretory defect. Deficiency of cellular immunity is known as one of the factors involved in the pathogenesis of T2DM. lymphocyte-specific protein tyrosine kinase( LCK) is an important gene involved in the intracellular signaling pathways of lymphocytes. This study aimed at determining and comparing <em>LCK</em> gene expression levels in diabetic patients compared with the healthy controls.<br>
<strong>Materials and Methods</strong><strong>:</strong> In this case-control study, 60 people, including 30 T2DM and 30 healthy people were included. The expression levels of the <em>LCK</em> gene were measured by real-time polymerase chain reaction and the obtained data were analyzed by T-test in GraphPad Prism6 software.<strong><em><span dir="RTL"></span></em></strong><br>
<strong>Results:</strong> The expression level of the <em>LCK</em> gene was increased in diabetic samples compared with the healthy samples (<em>P</em>= 0.0001).<br>
<strong>Conclusion</strong><strong>:</strong> The results suggested that changes in the expression levels of <em>LCK</em> gene can play a role in the pathogenesis of T2DM.<strong><em><span dir="RTL"></span></em></strong>
Type 2 diabetes mellitus, LCK gene, Gene expression
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http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-334&slc_lang=en&sid=1
Zahra
Rahvarzadeh