en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate </span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">insulin signaling pathways and</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""> glucose homeostasis. This study aimed to compare <i>FOXO1</i> expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and Methods</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">21 male wistar rats (220&plusmn;<st1:metricconverter productid="20 g" w:st="on">20 g</st1:metricconverter>) were obese by 6 weeks high fat diet (HFD) and randomly assigned to either non-diabetes (n=7) or two T2D groups (control and exercise groups, n=<st1:metricconverter productid="7 in" w:st="on">7 in</st1:metricconverter> each case). Fasting glucose, insulin, insulin resistance and <i>FOXO1</i> expression were compared between non-diabetes and diabetes groups. All variables were also assigned after resistance training</span></span><b> </b><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">in the form of climbing a ladder</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""> (6 weeks/5 times weekly) in exercise compare with control groups. Data were compared by ANOVA, independent and paired t-test methods (<i>P</i></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><0.05).<b><i></i></b></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Induction of diabetes </span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">resulted in significant increase in insulin resistance, glucose, and <i>FOXO</i> expression in SA tissue and a decrease in insulin compared to obese health rats (<i>P</i>< 0.0001). A significant decrease in fasting insulin (<i>P</i>< 0.0001), insulin resistance (<i>P</i>< 0.0001) and <i>FOXO1</i> expression in SA tissue (<i>P</i>< 0.0001) and increase in insulin (<i>P</i>: 0.002) were observed by resistance training compared to control diabetes rats.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Based on our results, improving insulin resistance and glucose in response to resistance training in obese diabetic rats may be rooted in decreased insulin expression following these exercises.</span></span><b><i><span dir="RTL" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></i></b></span></span></span></span><br> &nbsp; Adipose tissue, Exercise, Insulin resistance, Diabetes 110 116 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-347&slc_lang=en&sid=1 Shahram Soheily 0000-0003-4407-1890 Yes Assistant professor of Exercise Physiology, Safadasht Branch, Islamic Azad University, Tehran, Iran. Mojtaba Eizadi 0000-0003-1989-692X No Assistant professor of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran.