en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Epidemiological evidence shows that the prevalence of patients with comorbidity of diabetes mellitus (DM), in Coronavirus disease 2019 (COVID-19) is remarkable and they have poor prognosis. We aimed to investigate the comorbidity of diabetes and covid-19 in positive Polymerase Chain Reaction people in Yazd.</span></span><span style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and Methods</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">This retrospective cohort study included data of 570 COVID-19 positive patients, admitted to Shahid Sadoughi Hospital in Yazd, Iran, from February2019 to May 2020, including demographic data and clinical outcome of COVID-19. Study data were analyzed using SPSS software-22 and T-test, </span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Chi-square and a binary logistic regression model were used for modeling</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">.</span></span><i><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></i></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">Prevalence of COVID-19 patients with diabetes was 27% and the percentage of male patients was 62.6%. Additionally, duration of hospitalization </span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">significantly higher in diabetic patients (</span></span><i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">= 0.004)</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">, need to invasive mechanical ventilation </span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">in diabetic patients was significantly higher than non-diabetic patients (</span></span><i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">˂ 0.001)</span></span><span style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">DM is one of the most important comorbidity with COVID-19 patients </span></span><span lang="EN" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">and this comorbidity affects the severity of the disease and the outcome of patients</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">.</span></span><b><i><span dir="RTL" style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></i></b></span></span></span></span><br> &nbsp; Diabetes mellitus, COVID-19, Comorbidity, Yazd 138 144 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-351&slc_lang=en&sid=1 Kazem Ansari 0000-0003-1869-4242 No MD, Nano-Biotech Foresight Company Biotechnology Campus, Yazd Stem Cells and Regenerative Medicine Institute, Yazd, Iran. Seyed Alireza Mousavi 0000-0003-3564-2698 No Assistant Professor, Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Cheraghipour 0000-0002-1381-9141 No MD, Islamic Azad University of Yazd, Yazd, Iran. Zohreh AkhoundiMeybodi 0000-0002-8409-4192 Yes Assistant Professor of Prevention and Control of Nosocomial Infection, Infectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.