en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">The thyroid gland is susceptible to the formation of nodules. Therefore, due to the critical role of selenium in the function of the thyroid gland, the impact of this element on the size and volume of this organ and its nodules were examined.</span></span><span style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and Methods</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">During three months, two groups consisting of 30 patients with benign thyroid nodules who were referred to Baghaeipour Endocrinology Clinic were given daily doses of 100 and 200 micrograms of selenium, and a control group of 30 people without selenium consumption were assessed.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">The results of intergroup analysis detected that the mean (&plusmn;SD) of nodules length in the 100 &micro;g selenium consumer group was 17.13 (&plusmn;7.9) and 14.93 (&plusmn;6.01) before and after intervention respectively (<i>P</i>= 0.008). About the nodules height in the 200 &micro;g selenium consumer group, the mean (&plusmn;SD) was 9.3 (&plusmn;2.8) and 8.93 (&plusmn;2.71) before and after intervention in that order (<i>P</i>= 0.001).</span></span></span></span></span></span><br> <b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion</span></span></span></span></b><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Our findings suggest that selenium has been effective in the size and volume of the<br> nodule and thyroid gland, as well as the TSH hormone, and further studies are needed to determine its therapeutic approach and efficacy.</span></span></span> Selenium, Thyroid gland, Nodule 219 222 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-361&slc_lang=en&sid=1 Samane Moradi 0000-0003-3830-5996 No Departments of Internal Medical, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Seyed Mohammad Mohammadi 0000-0002-1837-1155 No Endocrinology & Metabolism, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Nasim Namiranian 0000-0002-5133-6204 No Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Mohammad Afkhami-Ardekani 0000-0001-9768-5904 Yes Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Omid Afkhami-Ardakani No Student, Factualty of Medicine, Pecs University, Hungary.