en تخصصي Special پژوهشي Research <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Objective:</span></span></span></b><b> </b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats.</span></span><span style="font-size:10.5pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Materials and Methods</span></span></span></b><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">For diabetes induction, male Wistar rats received STZ (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction. Rats were randomly divided into 5 groups of 6 members and one square centimeter (cm²) wound was<span class="msoIns" style="text-decoration:underline"><span style="color:teal"><ins cite="mailto:injinari" datetime="2022-08-09T10:04"> </ins></span></span>surgically induced in the dorsal region of each rat. The test groups were treated with ANGIPARS, undiluted royal jelly N chromosome, and royal jelly N chromosome 5% separately. The control groups were including non-diabetic and untreated diabetic rats. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span lang="EN" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">The findings indicate a significant acceleration in wound healing of the diabetic rats treated by ANGIPARS ointment or royal jelly N chromosomes 5%</span></span><i><span dir="RTL" lang="FA" style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">.</span></span></i><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""> RJ also shortened the healing period of desquamated skin lesions. Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats.</span></span></span></span></span></span><br> <b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion</span></span></span></span></b><b><span style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">:</span></span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Regarding the mentioned findings, royal jelly as a natural product may play an effective role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair. Nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended</span></span></span><i><span dir="RTL" lang="FA" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">.</span></span></span></i> Diabetes mellitus, Wound healing, Natural products, Drug effects 223 230 http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-362&slc_lang=en&sid=1 Saeed Ahmadi Majd 0000-0002-0186-8237 No Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran. Mohammad Rabbani Khorasgani 0000-0002-4043-9216 Yes Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran. Sayed Rasoul Zaker 0000-0002-6703-9431 No Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran. Maryam Khezri 0000-0001-9065-7919 No Department of Chemistry, Faculty of Chemistry, University of Isfahan, Isfahan, Iran. Azam Aliasghari Veshareh 0000-0001-8645-0894 No Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.